Results 51 to 60 of about 258,864 (288)

Ultrasound-Modulated Macrophages Inhibit Keloid Formation Via Egr1

International Dental Journal
Aim or purpose: This study investigates ultrasound-mediated macrophage reprogramming through the Egr1/Thbs1 axis to suppress keloid formation, aiming to establish a macrophage-targeted therapeutic strategy for pathological scar management.
Qinchao Tang, Shuang Liu, Yanyun Pang, Bing Zhang   +3 more
doaj   +1 more source

Inflammatory stimuli reprogram macrophage phagocytosis to macropinocytosis for the rapid elimination of pathogens. [PDF]

PLoS Pathogens, 2014
Following an infectious challenge, macrophages have to be activated in order to allow efficient clearance of infectious pathogens, but how macrophage activation is coupled to increased clearance remains largely unknown. We here describe that inflammatory
Somdeb Bosedasgupta, Jean Pieters
doaj   +1 more source

MTHFD2 reprograms macrophage polarization by inhibiting PTEN

Cell Reports, 2023
The one-carbon metabolism enzyme methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is involved in the regulation of tumor oncogenesis and immune cell functions, but whether it can contribute to macrophage polarization remains elusive. Here, we show that MTHFD2 suppresses polarization of interferon-γ-activated macrophages (M(IFN-γ)) but enhances that ...
Man Shang, Lina Ni, Xiao Shan, Yan Cui, Penghui Hu, Zemin Ji, Long Shen, Yanan Zhang, Jinxue Zhou, null Bing Chen, Ting Wang, Qiujing Yu   +11 more
openaire   +3 more sources

Macrophage Reprogramming via Targeted ROS Scavenging and COX‑2 Downregulation for Alleviating Inflammation

, 2023
Inflammation-related diseases affect large populations of people in the world and cause substantial healthcare burdens, which results in significant costs in time, material, and labor. Preventing or relieving uncontrolled inflammation is critical for the
Dongxia Chen (4248469), Yuhang Jiang (2344720), Cuicui Zuo (14709090), Jinhao Gao (1449100), Limin Chen (90676), Hui Xiong (541837), Hongyu Lin (696543), Yifan Fan (6704186), Xiangjie Luo (10630815)   +8 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

PKM2: A gatekeeper in macrophage metabolic reprogramming

Journal of Pharmaceutical Analysis
Metabolic reprogramming serves as a core adaptive mechanism for cells to respond to microenvironmental changes and plays a decisive role in macrophage functional polarization.
Ke Li, Mingyu Wu, Qiuyu Zhang, Jiabin Wu, Xianyi Ding, Weihua Xiao   +5 more
doaj   +1 more source

Adhesion molecule-dependent mechanisms regulate the rate of macrophage clearance during the resolution of peritoneal inflammation [PDF]

, 2002
Macrophage clearance is essential for the resolution of inflammation. Much is known about how monocytes enter the inflammatory site but little is known about how resultant macrophages are cleared. We have previously demonstrated that macrophage clearance
Mutsaers, SE, Bottoms, S, Cooksley, H, Helen Cauldwell, Bellingan, GJ, Christopher Haslett, Xu, P, Haslett, C, Geoffrey John Laurent, Steven Eugene Mutsaers, Anthony Shock, Laurent, GJ, Ping Xu, Stephen Bottoms, Cauldwell, H, Shock, A, Helen Cooksley, Geoffrey John Bellingan   +17 more
core   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

C16, a novel sinomenine derivatives, promoted macrophage reprogramming toward M2-like phenotype and protected mice from endotoxemia

International Journal of Immunopathology and Pharmacology, 2021
Macrophage plays a critical part in host defense, tissue repair, and anti-inflammation; Macrophage reprogramming is responsible for disease development or regression.
Ping Ni, Yue-Qin Liu, Jin-Yu Man, Wang Li, Shan-Shan Xue, Tao-Hong Lu, Zhao-Liang Su, Cheng-Lin Zhou   +7 more
doaj   +1 more source

A Highly Optimized Protocol for Reprogramming Cancer Cells to Pluripotency Using Nonviral Plasmid Vectors

, 2015
In spite of considerable interest in the field, reprogramming induced pluripotent stem cells (iPSCs) directly from cancer cells has encountered considerable challenges, including the extremely low reprogramming efficiency and instability of cancer ...
Huang, FP, Ning, J, Davies, TJ, Fairchild, PJ, Sachamitr, P, Zhao, HZ, Chang, Y, Sattler, S   +7 more
core   +1 more source