Results 1 to 10 of about 4,760 (127)

Lipoxin A4 attenuates the lung ischaemia reperfusion injury in rats after lung transplantation [PDF]

Annals of Medicine, 2021
Background Lung ischaemia reperfusion injury (LIRI) is the major cause of primary lung dysfunction after lung transplantation. Lipoxin A4 inhibits the oxidative stress and inflammation.
Lijuan Zhang, Qihang Tai, Guangxiao Xu, Wei Gao   +3 more
doaj   +2 more sources

Synthesis of aromatic lactone analogues of Lipoxin A4 [PDF]

BMC Research Notes, 2022
Objective Synthesis of novel aromatic Lipoxin A4 lactone analogues. Results Novel para-substituted aromatic lactone analogues of Lipoxin A4 have been synthesized in a convergent manner with six steps in the longest linear sequence in 12–13% yields ...
Aya Ismael, Muhammad Zeeshan, Jørn H. Hansen   +2 more
doaj   +2 more sources

Nanostructured Lipoxin A4: Understanding Its Biological Behavior and Impact on Alzheimer’s Disease (Proof of Concept) [PDF]

Pharmaceutics
Background/Objectives: Lipoxins, particularly Lipoxin A4 (LXA4), are endogenous lipid mediators with potent anti-inflammatory and pro-resolving properties, making them promising candidates for the treatment of inflammatory and neurodegenerative disorders.
Natália Cristina Gomes-da-Silva, Isabelle Xavier-de-Britto, Marilia Amável Gomes Soares, Natalia Mayumi Andrade Yoshihara, Derya Ilem Özdemir, Eduardo Ricci-Junior, Pierre Basílio Almeida Fechine, Luciana Magalhães Rebelo Alencar, Maria das Graças Muller de Oliveira Henriques, Thereza Christina Barja-Fidalgo, Cristian Follmer, Ralph Santos-Oliveira   +11 more
doaj   +2 more sources

Evaluation of the Effects of Lipoxin A4 and Resolvin D1 on the Severity of Transient Tachypnea of the Newborn: A Prospective Study [PDF]

Children
Objective: Transient tachypnea of the newborn (TTN) is a common condition observed in neonates. Since its management often requires intensive care and leads to maternal–infant separation, it is a major source of parental concern.
Emrah Çığrı, Funda Çatan İnan, Sedat Gülten, Mehmet Akif Bildirici, Ayşe Ece Gökkaya, Metin Asıleren, Fethiye Yıldız, Hilmi Onur Kabukcu   +7 more
doaj   +2 more sources

Lipoxin A4 and Resolvin D1 Preserve Neural Inductive Capacity of Dental Pulp Stem Cells Cultured Under Inflammatory Conditions. [PDF]

Cell Biol Int
ABSTRACT Human dental pulp stem cells (DPSCs) exhibit neurogenic differentiation potential; however, inflammatory conditions may impair this process. This study investigated the impact of tumor necrosis factor alpha (TNF‐α) on the neurodifferentiation potential of DPSCs and the modulatory role of the pro‐resolving lipid mediators lipoxin A4 (LXA4) and ...
Turrioni AP, da Silva GP, Xu Y, Kantarci A, Hasturk H, Battaglino RA, Morse LR.   +6 more
europepmc   +2 more sources

Lipoxin A4 Reduces Ventilator-Induced Lung Injury in Rats with Large-Volume Mechanical Ventilation [PDF]

Mediators of Inflammation, 2020
Ventilator-induced lung injury (VILI) is a severe and inevitable complication in patients who require mechanical ventilation (MV) for respiratory support. Lipoxin A4 is an endogenous anti-inflammatory and antioxidant mediator.
Qi Wang, Guang-xiao Xu, Qi-hang Tai, Yan Wang   +3 more
doaj   +2 more sources

Lipoxin and Aspirin-Triggered Lipoxins

Scientific World Journal, The, 2010
Lipoxins and their 15 epimers, aspirin triggered lipoxins (ATL), are eicosanoids derived from sequential lipoxygenase (LO) metabolism of arachidonic acid.
Mario Romano, Romano Mario
exaly   +2 more sources

Natural Compounds Such as Hericium erinaceus and Coriolus versicolor Modulate Neuroinflammation, Oxidative Stress and Lipoxin A4 Expression in Rotenone-Induced Parkinson’s Disease in Mice [PDF]

Biomedicines, 2022
Background: A growing body of research suggests that oxidative stress and neuroinflammation are early pathogenic features of neurodegenerative disorders. In recent years, the vitagene system has emerged as a potential target, as it has been shown to have
Marika Cordaro, Sergio Modafferi, Ramona D’Amico, Roberta Fusco, Tiziana Genovese, Alessio Filippo Peritore, Enrico Gugliandolo, Rosalia Crupi, Livia Interdonato, Davide Di Paola, Daniela Impellizzeri, Salvatore Cuzzocrea, Vittorio Calabrese, Rosanna Di Paola, Rosalba Siracusa   +14 more
doaj   +2 more sources

Lipoxin A4 (LXA4) as a Potential Drug for Diabetic Retinopathy [PDF]

Medicina
The purpose of this review is to propose that lipoxin A4 (LXA4), derived from arachidonic acid (AA), a potent anti-inflammatory, cytoprotective, and wound healing agent, may be useful to prevent and manage diabetic retinopathy (DR).
Undurti N. Das
doaj   +2 more sources

Association between arachidonate lipoxygenase 15,c.-292 C > T gene polymorphism and non-cystic fibrosis bronchiectasis in children: a pilot study on the effects on airway lipoxin A4 and disease phenotype [PDF]

Italian Journal of Pediatrics
Background Persistent airway inflammation is a central feature of bronchiectasis. Arachidonate 15-lipoxygenase (ALOX-15) controls production of endogenous lipid mediators, including lipoxins that regulate airway inflammation.
Mahitab Morsy Hussein, Eman Mahmoud Fouda, Yasmine Shehab, Enas Samir Nabih, Ahmed Mohamed Osman, Sally Raafat Ishak   +5 more
doaj   +2 more sources