Results 31 to 40 of about 5,641 (199)

Time-Dependent Protective and Pro-Resolving Effects of FPR2 Agonists on Lipopolysaccharide-Exposed Microglia Cells Involve Inhibition of NF-κB and MAPKs Pathways

Cells, 2021
Prolonged or excessive microglial activation may lead to disturbances in the resolution of inflammation (RoI). The importance of specialized pro-resolving lipid mediators (SPMs) in RoI has been highlighted.
Kinga Tylek, Ewa Trojan, Monika Leśkiewicz, Magdalena Regulska, Natalia Bryniarska, Katarzyna Curzytek, Enza Lacivita, Marcello Leopoldo, Agnieszka Basta-Kaim   +8 more
doaj   +1 more source

Role of the lipoxin A4 receptor in the development of neutrophil extracellular traps in Leishmania infantum infection

Parasites & Vectors, 2019
Background Neutrophils play an immunomodulatory role through the release of neutrophil extracellular traps (NETs). NETs are released in response to Leishmania infection, but the mechanism of NET extrusion has not been elucidated.
Furong Wei, Wenci Gong, Junyun Wang, Yuetao Yang, Jianxiu Liu, Yanjuan Wang, Jianping Cao   +6 more
doaj   +1 more source

Overexpression of apolipoprotein A1 in the lung abrogates fibrosis in experimental silicosis. [PDF]

PLoS ONE, 2013
The inhalation of silica particles induces silicosis, an inflammatory and fibrotic lung disease characterized by the early accumulation of macrophages and neutrophils in the airspace and subsequent appearance of silicotic nodules as a result of ...
Eun hee Lee, Eun-ju Lee, Hee jeong Kim, An soo Jang, Eun suk Koh, Soo-taek Uh, Yong hoon Kim, Sung-woo Park, Choon-sik Park   +8 more
doaj   +1 more source

Lipoxins reduce obesity-induced adipose tissue inflammation in 3D-cultured human adipocytes and explant cultures

iScience, 2022
Summary: Adipose tissue inflammation drives obesity-related cardiometabolic diseases. Enhancing endogenous resolution mechanisms through administration of lipoxin A4, a specialized pro-resolving lipid mediator, was shown to reduce adipose inflammation ...
Matúš Soták, Meenu Rohini Rajan, Madison Clark, Matthew Harms, Alankrita Rani, Jamie D. Kraft, David Tandio, Tong Shen, Kamil Borkowski, Oliver Fiehn, John W. Newman, Marianne Quiding-Järbrink, Christina Biörserud, Peter Apelgren, Trude Staalesen, Carolina E. Hagberg, Jeremie Boucher, Ville Wallenius, Stephan Lange, Emma Börgeson   +19 more
doaj   +1 more source

Innate immunity is a key factor for the resolution of inflammation in asthma [PDF]

European Respiratory Review, 2015
The resolution of inflammation is an integral and natural part of the physiological response to tissue injury, infection and allergens or other noxious stimuli.
Cindy Barnig, Bruce D. Levy
doaj   +1 more source

Novel biphasic role of lipoxinA4 on expression of cyclooxygenase-2 in lipopolysaccharide-stimulated lung fibroblasts [PDF]

, 2011
Fibroblasts are important to host defence and immunity, can also as initiators of inflammation as well. As the endogenous "braking signal", Lipoxins can regulate anti-inflammation and the resolution of inflammation.
Gao, F., Song, X. R., QingQuan Lian, Jin, Shengwei, Shengxing Zheng, Duyun Ye, He, Q., Fang Gao, Jin, S. W., Gao, Fang; id_orcid, Xiaorong Song, He, Qian, Qian Wang, Ye, Duyun, Wang, Q., Zheng, Shengxing, Ye, D. Y., Lian, Q. Q., Lian, QingQuan, Shengwei Jin, Song, Xiaorong, Qian He, Wang, Qian, Smith, F. Gao (Fang Gao), Zheng, S. X.   +24 more
core   +1 more source

Dysregulation of prostaglandins, leukotrienes and lipoxin A₄ in bronchiectasis. [PDF]

Thorax, 2022
IntroductionBronchiectasis is characterised by excessive neutrophilic inflammation. Lipid mediators such as prostaglandins and leukotrienes have crucial roles in the inflammatory response. Further characterisation of these lipids and understanding the interplay of anti-inflammatory and proinflammatory lipid mediators could lead to the development of ...
Bedi P, Ziegler K, Whitfield PD, Davidson D, Rossi AG, Hill AT.   +5 more
europepmc   +6 more sources

Pilot application of lipoxin A4 analog and lipoxin A4 receptor agonist in asthmatic children with acute episodes

Experimental and Therapeutic Medicine, 2017
Previous studies have demonstrated that lipoxin A4 (LXA4) analogs blocked both airway hyper-responsiveness and pulmonary inflammation in a murine model of asthma. The present pilot study investigated the initial efficacy and safety of inhaled 5(S),6(R)-LXA4 methyl ester and BML-111, a LXA4 agonist, in the treatment of asthmatic children with acute ...
Xia, Kong, Sheng-Hua, Wu, Li, Zhang, Xiao-Qing, Chen   +3 more
openaire   +3 more sources

Lipoxin A4 ameliorates lipopolysaccharide-induced lung injury through stimulating epithelial proliferation, reducing epithelial cell apoptosis and inhibits epithelial–mesenchymal transition

Respiratory Research, 2019
Background Acute respiratory distress syndrome (ARDS) is characterized by alveolar epithelial disruption. Lipoxins (LXs), as so-called “braking signals” of inflammation, are the first mediators identified to have dual anti-inflammatory and inflammatory ...
Jing-xiang Yang, Ming Li, Xin-ou Chen, Qing-quan Lian, Qian Wang, Fang Gao, Sheng-wei Jin, Sheng-xing Zheng   +7 more
doaj   +1 more source

Dual role of lipoxin A4 in pneumosepsis pathogenesis

International Immunopharmacology, 2013
Lipoxin A4 (LXA4) is an endogenous lipid mediator with potent anti-inflammatory actions but its role in infectious processes is not well understood. We investigated the involvement of LXA4 and its receptor FPR2/ALX in the septic inflammatory dysregulation. Pneumosepsis was induced in mice by inoculation of Klebsiella pneumoniae.
Sordi, Regina, Menezes-de-Lima, Octávio, Horewicz, Verônica, Scheschowitsch, Karin, Santos, Laís F., Assreuy, Jamil   +5 more
openaire   +2 more sources