Results 21 to 30 of about 5,641 (199)
Blood, 2013 Key Points Fpr2/3 activation controls platelet/neutrophil aggregates to afford LXA4 synthesis, thus inhibiting vascular inflammation on reperfusion. Aspirin can jumpstart this circuit by triggering 15-epi-lipoxin synthesis.
BRANCALEONE, VINCENZO +8 more
openaire +5 more sources
Influence of Lipoxin-A4 Treatment on Cytokine, Chemokine Genes Expression, and Phenotypic Distribution of Lymphocyte Subsets During Experimental Liver Fibrosis. [PDF]
Eurasian J Med, 2022 Objective: Lipoxins are anti-inflammatory, pro-resolving molecules that are secreted by immune cells such as neutrophils and macrophages. Lipoxins are a metabolite of the arachidonic acid pathway that resolve inflammation in fibrotic liver by producing ...
Karaca ZM +3 more
europepmc +2 more sources
Lipoxin A4 (LXA4) as a Potential Drug for Autoimmune Uveitis [PDF]
Balkan Medical JournalUndurti Narasimha Das
doaj +2 more sources
Resolving lipoxin A4: Endogenous mediator or exogenous anti-inflammatory agent? [PDF]
Journal of Lipid ResearchReagan M. McGuffee +2 more
doaj +2 more sources
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Lipoxin A4 and platelet activating factor are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice. [PDF]
PLoS ONE, 2014 CFTR (cystic fibrosis transmembrane conductance regulator) is expressed by both neutrophils and platelets. Lack of functional CFTR could lead to severe lung infection and inflammation.
Haiya Wu +11 more
doaj +1 more source
Journal of Lipid Research, 2023 A characteristic fragmentation was observed for PUFAs that contain allylic vicinal diol groups (resolvin D1, D2, D4, E3, lipoxin A4, B4, and maresin 2), which were derivatized with N,N-dimethylethylenediamine (DMED), in positive-ion ESI-MS/MS.
Huibin Zhu +5 more
doaj +1 more source
The role of Lipoxin A4 in endometrial biology and endometriosis [PDF]
Mucosal Immunology, 2013 Lipoxin A4 (LXA4), an endogenous anti-inflammatory and immunomodulatory mediator studied in many disease states, is recently appreciated as a potentially significant player in the endometrium. This eicosanoid, synthesized from arachidonic acid via the action of lipoxygenase enzymes, is likely regulated in endometrial tissue during the menstrual cycle ...
G O, Canny, B A, Lessey
openaire +2 more sources
Lipoxin A4 Is Increased in the Plasma of Preeclamptic Women [PDF]
American Journal of Hypertension, 2016 Excessive inflammation is involved in preeclampsia (PE) pathogenesis. Lipoxin A4 (LXA4) is an eicosanoid that counter-regulates inflammation. The main objective of this study was to determine LXA4 plasma levels in PE women. The correlations among LXA4 levels, ultrasensitive C-reactive protein (us-CRP) levels, and clinical/laboratory parameters of the ...
Luiza O, Perucci +6 more
openaire +2 more sources
Lipoxin A4 promotes lung epithelial repair whilst inhibiting fibroblast proliferation
ERJ Open Research, 2016 Therapy that promotes epithelial repair whilst protecting against fibroproliferation is critical for restoring lung function in acute and chronic respiratory diseases.
Shengxing Zheng +10 more
doaj +1 more source