Synthesis of aromatic lactone analogues of Lipoxin A4 [PDF]
BMC Research Notes, 2022 Objective Synthesis of novel aromatic Lipoxin A4 lactone analogues. Results Novel para-substituted aromatic lactone analogues of Lipoxin A4 have been synthesized in a convergent manner with six steps in the longest linear sequence in 12–13% yields ...
Aya Ismael +2 more
doaj +8 more sources
Lipoxin A4 attenuates the lung ischaemia reperfusion injury in rats after lung transplantation [PDF]
Annals of Medicine, 2021 Background Lung ischaemia reperfusion injury (LIRI) is the major cause of primary lung dysfunction after lung transplantation. Lipoxin A4 inhibits the oxidative stress and inflammation.
Lijuan Zhang +3 more
doaj +3 more sources
Nanostructured Lipoxin A4: Understanding Its Biological Behavior and Impact on Alzheimer’s Disease (Proof of Concept) [PDF]
PharmaceuticsBackground/Objectives: Lipoxins, particularly Lipoxin A4 (LXA4), are endogenous lipid mediators with potent anti-inflammatory and pro-resolving properties, making them promising candidates for the treatment of inflammatory and neurodegenerative disorders.
Natália Cristina Gomes-da-Silva +11 more
doaj +3 more sources
Lipoxin A4 Reduces Ventilator-Induced Lung Injury in Rats with Large-Volume Mechanical Ventilation [PDF]
Mediators of Inflammation, 2020 Ventilator-induced lung injury (VILI) is a severe and inevitable complication in patients who require mechanical ventilation (MV) for respiratory support. Lipoxin A4 is an endogenous anti-inflammatory and antioxidant mediator.
Qi Wang +3 more
doaj +3 more sources
Lipoxin A4 (LXA4) as a Potential Drug for Diabetic Retinopathy [PDF]
MedicinaThe purpose of this review is to propose that lipoxin A4 (LXA4), derived from arachidonic acid (AA), a potent anti-inflammatory, cytoprotective, and wound healing agent, may be useful to prevent and manage diabetic retinopathy (DR).
Undurti N. Das
doaj +4 more sources
THE ROLE OF LIPOXIN A4 IN CYSTIC FIBROSIS LUNG DISEASE [PDF]
Computational and Structural Biotechnology Journal, 2013 In Cystic Fibrosis (CF), mutations of the CFTR gene result in defective Cl− secretion and Na+ hyperabsorption by epithelia which leads to airway lumen dehydration and mucus plugging and favours chronic bacterial colonization, persistent inflammation and ...
Valérie Urbach +3 more
doaj +4 more sources
Airway Lipoxin A4 Generation and Lipoxin A4 Receptor Expression Are Decreased in Severe Asthma [PDF]
American Journal of Respiratory and Critical Care Medicine, 2008 Abstract Rationale Airway inflammation is common in severe asthma despite antiinflammatory therapy with corticosteroids. Lipoxin A4 (LXA4) is an arachidonic acid–derived mediator that serves as an agonist for resolution of inflammation ...
Planaguma, Anna +16 more
openaire +5 more sources
Study Of Role Of Lipoxin – A4 In Psoriasis [PDF]
Egyptian Journal of Medical Research, 2022 The aim of this work was to evaluate the level of lipoxin – A4 (LXA4) in patients with psoriasis and its correlation with clinical parameters. This study included 25 psoriatic patients who were recruited from the outpatient clinics of dermatology ...
Hanan Al Nemr +3 more
doaj +2 more sources
Evaluation of the Effects of Lipoxin A4 and Resolvin D1 on the Severity of Transient Tachypnea of the Newborn: A Prospective Study [PDF]
ChildrenObjective: Transient tachypnea of the newborn (TTN) is a common condition observed in neonates. Since its management often requires intensive care and leads to maternal–infant separation, it is a major source of parental concern.
Emrah Çığrı +7 more
doaj +2 more sources
Mediators of Inflammation, 2013 The lipoxins are the first proresolution mediators to be recognized and described as the endogenous “braking signals” for inflammation. We evaluated the anti-inflammatory and proresolution bioactions of lipoxin A4 in our lipopolysaccharide (LPS-)induced ...
Yi Yang +10 more
doaj +2 more sources