Age-dependent relevance of endogenous 5-lipoxygenase derivatives in anxiety-like behavior in mice.
PLoS ONE, 2014 When 5-lipoxygenase (5-LO) is inhibited, roughly half of the CNS effect of the prototypic endocannabinoid anandamide (AEA) is lost. Therefore, we decided to investigate whether inhibiting this enzyme would influence physiological functions classically ...
Luciana M Leo +5 more
doaj +1 more source
Inflammation and pro-resolution inflammation after hepatobiliary surgery
World Journal of Surgical Oncology, 2017 Background The magnitude of the perioperative inflammatory response plays a role in surgical outcomes. However, few studies have explored the mechanisms of the resolution of inflammation in the context of surgery. Here, we described the temporal kinetics
Juan P. Cata +7 more
doaj +1 more source
Dual role of lipoxin A4 in pneumosepsis pathogenesis
International Immunopharmacology, 2013 Lipoxin A4 (LXA4) is an endogenous lipid mediator with potent anti-inflammatory actions but its role in infectious processes is not well understood. We investigated the involvement of LXA4 and its receptor FPR2/ALX in the septic inflammatory dysregulation. Pneumosepsis was induced in mice by inoculation of Klebsiella pneumoniae.
Sordi, Regina +5 more
openaire +2 more sources
Papel dual da lipoxina A4, nas alterações inflamatórias e cardiovasculares na sepse: uma janela de oportunidade [PDF]
, 2013 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2013.A pneumonia é uma das principais causas de sepse, que por sua vez é a maior causa de morte nas ...
Sordi, Regina de
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Lipoxina A4 na dor neuropática após a lesão medular: modulação da neuroinflamação e ativação microglial [PDF]
, 2015 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2015.A dor crônica está presente na maioria dos pacientes após a lesão medular traumática (LMT).
Martini, Alessandra Cadete
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Transcellular biosynthesis of lipoxin A4 during adhesion of platelets and neutrophils in experimental immune complex glomerulonephritis [PDF]
, 1995 Transcellular biosynthesis of lipoxin A4 during adhesion of platelets and neutrophils in experimental immune complex glomerulonephritis. Polymorphonuclear neutrophils are important effectors of injury in host defense and inflammation.
Phillips, M. Laurie +4 more
core +1 more source
Lipoxina A4: um modulador alostérico endocanabinóide no sistema nervoso central [PDF]
, 2012 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciênicas Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2010Lipoxinas e endocanabinóides são eicosanóides endógenos que são liberados sob demanda em resposta à ...
Pamplona, Fabrício Alano
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Histiocytes: Multifaceted Regulators of Health and Disease
Veterinary Clinical Pathology, EarlyView.ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley +1 more source
Therapeutic activity of lipoxin A4 in TiO2-induced arthritis in mice: NF-κB and Nrf2 in synovial fluid leukocytes and neuronal TRPV1 mechanisms [PDF]
, 2023 BACKGROUND: Lipoxin A4 (LXA METHODS: Mice were stimulated with TiO RESULTS: LXA CONCLUSION ...
et al., +3 more
core +1 more source
Post‐Tuberculosis Lung Disease: Clinicopathologic Insights, Diagnosis, Prevention, and Management
MedComm, Volume 7, Issue 10, October 2026.A comprehensive review on post‐tuberculosis lung disease (PTLD) addresses the epidemiology, pathogenesis, clinical phenotypes and management, risk factors, prevention and systems approach, and future directions. This review provides standardized definitions, mechanistic insights and biomarkers of PTLD development, and clinical strategies for PTLD ...
Radha Gopalaswamy, Selvakumar Subbian
wiley +1 more source