Results 71 to 80 of about 5,641 (199)

Therapeutic activity of lipoxin A4 in TiO2-induced arthritis in mice: NF-κB and Nrf2 in synovial fluid leukocytes and neuronal TRPV1 mechanisms

, 2023
BACKGROUND: Lipoxin A4 (LXA METHODS: Mice were stimulated with TiO RESULTS: LXA CONCLUSION ...
et al.,, Saraiva-Santos, Telma, Pinho-Ribeiro, Felipe A, Zaninelli, Tiago H   +3 more
core   +2 more sources

Modulation of Neutrophil Apoptosis and the Resolution of Inflammation through β2 Integrins

Frontiers in Immunology, 2013
Precise control of the neutrophil death program provides a balance between their defence functions and safe clearance, whereas impaired regulation of neutrophil death is thought to contribute to a wide range of inflammatory pathologies.
Driss eEl Kebir, Janos G Filep
doaj   +1 more source

Association of SPHK1 polymorphisms with Alzheimer's disease susceptibility: Functional impact of the rs2247856 SNP on transcriptional efficiency

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 3, July/September 2026.
Abstract INTRODUCTION Sphingosine kinase 1 (SPHK1) has been implicated in the regulation of pro‐resolving lipid mediators relevant to neuroinflammation in Alzheimer's disease (AD). However, no studies have evaluated the genetic association between SPHK1 polymorphisms and AD susceptibility.
Dong‐Ju Kim, Yong‐Chan Kim, Byung‐Hoon Jeong   +2 more
wiley   +1 more source

Effect of Lipoxin A4 on bleomycin induced cytotoxicity in IMR-32 cells.

, 2014
(A) Effect of pre-treatment with different doses (1, 5, 10 ng/ml) of lipoxin A4 on bleomycin (60 µg/ml) induced cytotoxicity to IMR-32 cells. Cells were pre incubated with lipoxin A4 for 5 hrs and then bleomycin for 24 hrs. MTT assay was performed.
Arul M. Mani (678608), Naveen K. V. Gundala (678609), Sailaja Polavarapu (678607), Siresha Bathina (678611), Anasuya D. Hari (678610), Undurti N. Das (678612)   +5 more
core   +1 more source

Simvastatin attenuates endothelial activation through 15-epi-lipoxin A4 production in murine chronic Chagas cardiomyopathy [PDF]

, 2017
Current treatments for chronic Chagas cardiomyopathy, a disease with high mortality rates and caused by the protozoan Trypanosoma cruzi, are unsatisfactory.
Castillo, Christian, Machado, Fabiana S., Liempi, Ana, Maya Arango, Juan, Cramer, Allysson, Pimentel, Pollyana, Kemmerling Weis, Ulrike, González Herrera, Fabiola   +7 more
core   +1 more source

Intervertebral disc degeneration, inflammation, and bioactive lipids

Recent Trends in Pharmacology
Intervertebral disc degeneration, inflammation, and bioactive lipidsIntervertebral disc degenerationIntervertebral disc (IVD) degeneration is a common condition that is associated with significant morbidity.
Undurti Das, Ahmet Hacımüftüoğlu
doaj   +1 more source

Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor

, 2002
Aspirin (ASA) and dexamethasone (DEX) are widely used anti-inflammatory agents yet their mechanism(s) for blocking polymorphonuclear neutrophil (PMN) accumulation at sites of inflammation remains unclear.
Fierro, I.M., Mauro Perretti, Egle Solito, Perretti, M., Nan Chiang, Stephen J Getting, La, M., Iolanda M. Fierro, Chiang, N., Marullo, S., Solito, E., Charles N. Serhan, Mylinh La, Getting, S.J., Serhan, C.N., Stefano Marullo   +15 more
core   +1 more source

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

iNew Medicine, Volume 2, Issue 2, June 2026.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong, Zhenyu Wang, Suyin Yang, Kaige Gao, Xin Yang, Min Tang   +5 more
wiley   +1 more source

Omega‐3 DHA as a blank canvas: A molecular approximation to how lipid mediators modulate LGR6 in inflammation resolution

Protein Science, Volume 35, Issue 6, June 2026.
Abstract The leucine‐rich repeat‐containing G protein‐coupled receptor 6 (LGR6) has a potential role in inflammation resolution and different cancer processes. In this study, we employed computational techniques, including molecular docking and molecular dynamics simulations of mammalian membrane‐embeded systems, to understand the activation mechanism ...
Álex Pérez‐Sánchez, Mireia Garcia‐Viloca, Àngels González‐Lafont, José M. Lluch   +3 more
wiley   +1 more source

Distinct Roles of Myeloid‐ and Hepatocyte‐PLA2G6 Deletion in Mice With Metabolic Dysfunction‐Associated Steatotic Liver Disease

Liver International, Volume 46, Issue 6, June 2026.
ABSTRACT Background and Aims Polymorphisms of group VIA calcium‐independent phospholipase A2 (iPLA2β or PLA2G6) are associated with Type‐2 diabetes, blood lipids and inflammation. Global deficiency in iPLA2β‐null mice elicited protection against hepatic steatosis but not hepatic inflammation after high‐fat diet (HFD) feeding.
Gang Li, Simone Staffer, Sabine Tuma‐Kellner, Uta Merle, Walee Chamulitrat   +4 more
wiley   +1 more source