Results 71 to 80 of about 93,050 (197)
Research on the Mechanism of Natural Products Acting on Chronic Obstructive Pulmonary Disease
Food Science &Nutrition, Volume 14, Issue 7, July 2026.This figure illustrates that approximately 80 natural compounds exert therapeutic effects against chronic obstructive pulmonary disease by targeting pathological mechanisms such as airway inflammation, oxidative stress, airway remodeling, mucus hypersecretion, emphysema, protease–antiprotease imbalance, apoptosis, and autophagy.
Shuna Wei, Xiaoju Liu
wiley +1 more source
Modulation of Neutrophil Apoptosis and the Resolution of Inflammation through β2 Integrins
Frontiers in Immunology, 2013 Precise control of the neutrophil death program provides a balance between their defence functions and safe clearance, whereas impaired regulation of neutrophil death is thought to contribute to a wide range of inflammatory pathologies.
Driss eEl Kebir, Janos G Filep
doaj +1 more source
Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions
MedComm, Volume 7, Issue 7, July 2026.Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An +4 more
wiley +1 more source
Blood, 2013 Key Points Fpr2/3 activation controls platelet/neutrophil aggregates to afford LXA4 synthesis, thus inhibiting vascular inflammation on reperfusion. Aspirin can jumpstart this circuit by triggering 15-epi-lipoxin synthesis.
BRANCALEONE, VINCENZO +8 more
openaire +4 more sources
S102 Lipoxin A4 Improves Efferocytosis Via Inhibition Of The Hmgb1 In Human Alveolar Macrophages
, 2014 IntroductionEffective clearance of apoptotic cells by macrophages, termed efferocytosis, is a pre-requisite for successful resolution of inflammation.
Dancer, R. +9 more
core +1 more source
Lipoxin A4 Regulates Natural Killer Cell and Type 2 Innate Lymphoid Cell Activation in Asthma
, 2022 Asthma is a prevalent disease of chronic inflammation in which endogenous counter-regulatory signaling pathways are dysregulated. Recent evidence suggests that innate lymphoid cells (ILCs), including natural killer (NK) cells and type 2 innate lymphoid ...
Barnig, Cindy +8 more
core +1 more source
Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 3, July/September 2026.Abstract INTRODUCTION Sphingosine kinase 1 (SPHK1) has been implicated in the regulation of pro‐resolving lipid mediators relevant to neuroinflammation in Alzheimer's disease (AD). However, no studies have evaluated the genetic association between SPHK1 polymorphisms and AD susceptibility.
Dong‐Ju Kim +2 more
wiley +1 more source
Decreased Levels of Lipoxin A4 and Annexin A1 in Wheezy Infants
, 2014 Objective: Wheezing is a common and challenging health issue in infancy and early childhood. Asthma diagnosis is frequent in patients with a history of recurrent wheezing.
GÖKAHMETOĞLU, Selma +3 more
core +1 more source
Effect of Lipoxin A4 on bleomycin induced cytotoxicity in IMR-32 cells.
, 2014 (A) Effect of pre-treatment with different doses (1, 5, 10 ng/ml) of lipoxin A4 on bleomycin (60 µg/ml) induced cytotoxicity to IMR-32 cells. Cells were pre incubated with lipoxin A4 for 5 hrs and then bleomycin for 24 hrs. MTT assay was performed.
Arul M. Mani (678608) +5 more
core +1 more source
The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets
iNew Medicine, Volume 2, Issue 2, June 2026.The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong +5 more
wiley +1 more source