Results 81 to 90 of about 93,050 (197)
Effect of Lipoxin A4 on Lipopolysaccharide-Induced Endothelial Hyperpermeability
The Scientific World Journal, 2011 Excessive oxidative stress, decreased antioxidant capacity, and enhanced cellular calcium levels are initial factors that cause endothelial cell (EC) hyperpermeability, which represents a crucial event in the pathogenesis of pre-eclampsia.
Huayan Pang +9 more
doaj +1 more source
Protein Science, Volume 35, Issue 6, June 2026.Abstract The leucine‐rich repeat‐containing G protein‐coupled receptor 6 (LGR6) has a potential role in inflammation resolution and different cancer processes. In this study, we employed computational techniques, including molecular docking and molecular dynamics simulations of mammalian membrane‐embeded systems, to understand the activation mechanism ...
Álex Pérez‐Sánchez +3 more
wiley +1 more source
Effect of lipoxin A4 on IMR-32 cells.
, 2014 IMR-32 cells were exposed to different doses (1, 5, 10 ng/ml) of lipoxin A4 and incubated for 24 hrs. At the end of treatment period, cell viability was measured by MTT assay.
Arul M. Mani (678608) +5 more
core +1 more source
The Scientific World Journal, 2010 The enzymatic oxygenation of polyunsaturated fatty acids by lipoxygenases and cyclo-oxygenases is a resourceful mode of formation of specific autacoids that regulate the extent and pace of the inflammatory response. Arachidonate-derived eicosanoids, such
Gerard L. Bannenberg
doaj +1 more source
Arachidonic acid in health and disease with focus on hypertension and diabetes mellitus: A review
Journal of Advanced Research, 2018 Arachidonic acid (AA 20:4n-6) is an essential component of cell membranes and modulates cell membrane fluidity. AA is metabolized by cyclo-oxygenase (COX), lipoxygenase (LOX) and cytochrome P450 enzymes to form several metabolites that have important ...
Undurti N. Das
doaj +1 more source
Periodontitis as a Model for Inflammatory Uncoupling of Bone Remodeling
Journal of Periodontal Research, Volume 61, Issue 6, Page 662-694, June 2026.Periodontitis can be viewed as a state of inflammatory uncoupling of bone remodeling, in which excessive osteoclast‐mediated resorption coexists with impaired bone formation. This review integrates emerging insights from osteoimmunology, osteocyte biology, mechanobiology, aging, and resolution pathways to position periodontitis as an accessible in vivo
Rafael Scaf de Molon +4 more
wiley +1 more source
Frontiers in Microbiology, 2019 Kaposi’s sarcoma-associated herpesvirus (KSHV) infection, particularly latent infection is often associated with inflammation. The arachidonic acid pathway, the home of several inflammation and resolution associated lipid mediators, is widely altered ...
Jayashree A. Chandrasekharan +1 more
doaj +1 more source
Liver International, Volume 46, Issue 6, June 2026.ABSTRACT Background and Aims Polymorphisms of group VIA calcium‐independent phospholipase A2 (iPLA2β or PLA2G6) are associated with Type‐2 diabetes, blood lipids and inflammation. Global deficiency in iPLA2β‐null mice elicited protection against hepatic steatosis but not hepatic inflammation after high‐fat diet (HFD) feeding.
Gang Li +4 more
wiley +1 more source
Simvastatin attenuates endothelial activation through 15-epi-lipoxin A4 production in murine chronic Chagas cardiomyopathy [PDF]
, 2017 Current treatments for chronic Chagas cardiomyopathy, a disease with high mortality rates and caused by the protozoan Trypanosoma cruzi, are unsatisfactory.
Castillo, Christian +7 more
core +1 more source
, 2002 Aspirin (ASA) and dexamethasone (DEX) are widely used anti-inflammatory agents yet their mechanism(s) for blocking polymorphonuclear neutrophil (PMN) accumulation at sites of inflammation remains unclear.
Fierro, I.M. +15 more
core +1 more source