Results 31 to 40 of about 14,265 (225)
Apoptosis recognition receptors regulate skin tissue repair in mice
eLife, 2023 Apoptosis and clearance of apoptotic cells via efferocytosis are evolutionarily conserved processes that drive tissue repair. However, the mechanisms by which recognition and clearance of apoptotic cells regulate repair are not fully understood. Here, we
Olivia Justynski +13 more
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Efferocytosis and autoimmune disease [PDF]
International Immunology, 2018 Abstract An enormous number of cells in the body die by apoptosis during development and under homeostasis. Apoptotic cells are swiftly engulfed by macrophages and digested into units. This removal of apoptotic cells is called ‘efferocytosis’.
Kawano, Mahiru, Nagata, Shigekazu
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Efferocytosis in the tumor microenvironment [PDF]
Seminars in Immunopathology, 2018 Within the course of a single minute, millions of cells in the human body will undergo programmed cell death in response to physiological or pathological cues. The diminished energetic capacity of an apoptotic cell renders the cell incapable of sustaining plasma membrane integrity.
Werfel, Thomas A., Cook, Rebecca S.
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Efferocytosis and Lung Disease [PDF]
Chest, 2013 In healthy individuals, billions of cells die by apoptosis each day. Clearance of these apoptotic cells, termed "efferocytosis," must be efficient to prevent secondary necrosis and the release of proinflammatory cell contents that disrupt tissue homeostasis and potentially foster autoimmunity.
Alexandra L, McCubbrey +1 more
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Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis
Hepatology, EarlyView., 2022 EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu +16 more
wiley +1 more source
The Role of Efferocytosis in Atherosclerosis [PDF]
Circulation, 2017 The necrotic core has long been a hallmark of the vulnerable atherosclerotic plaque. Although apoptotic cells are cleared quickly in almost all other tissue beds, their removal appears to be significantly impaired in the diseased blood vessel. Emerging evidence indicates that this phenomenon is caused by a defect in efferocytosis, the process by which ...
Yoko, Kojima +2 more
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Cell Death and Disease, 2023 The efficient clearance of dead and dying cells, efferocytosis, is critical to maintain tissue homeostasis. In the bone marrow microenvironment (BMME), this role is primarily fulfilled by professional bone marrow macrophages, but recent work has shown ...
Emily R. Quarato +11 more
doaj +1 more source
Internalization of apoptotic cells during efferocytosis requires Mertk-mediated calcium influx
Cell Death and Disease, 2023 Phagocytosis of apoptotic cells, called efferocytosis, requires calcium inside and outside of phagocytes. Due to its necessity, calcium flux is sophisticatedly modulated, and the level of intracellular calcium in phagocytes is ultimately elevated during ...
Susumin Yang +8 more
doaj +1 more source
Cell Death Discovery, 2023 Aged livers have shown aggravated liver ischemia and reperfusion (IR) injury. Timely efferocytosis of apoptotic cells is a key mechanism for avoiding excessive inflammation and tissue injury.
Haoran Hu +11 more
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annotated images efferocytosis
, 2023 annotated images efferocytosis (see main project)
Bérénice A. Benayoun (10152083) +2 more
core +1 more source