Results 31 to 40 of about 11,135 (204)

Boosting efferocytosis in alveolar space using BCG vaccine to protect host against influenza pneumonia. [PDF]

PLoS ONE, 2017
Efferocytosis by alveolar phagocytes (APs) is pivotal in maintenance of lung homeostasis. Increased efferocytosis by APs results in protection against lethal acute lung injury due to pulmonary infections whereas defective efferocytosis by APs results in ...
Sanjay Mukherjee, Renuka Subramaniam, Han Chen, Anthony Smith, Shiva Keshava, Homayoun Shams   +5 more
doaj   +1 more source

Macrophage Efferocytosis in Heart. [PDF]

Arterioscler Thromb Vasc Biol
Efficient clearance of dying cells by efferocytosis is critical for organ development, inflammation resolution, and tissue repair. In the heart, the stakes of efficient clearance are high in that inefficient efferocytosis promotes an inflammatory environment that stresses the health of surrounding ...
Inui H, Yu X, Pfrender E, Bednarek J, Zhang L, Thorp EB.   +5 more
europepmc   +3 more sources

MFG-E8 and HMGB1 Are Involved in the Mechanism Underlying Alcohol-Induced Impairment of Macrophage Efferocytosis

Molecular Medicine, 2013
Efferocytosis is a unique phagocytic process for macrophages to remove apoptotic cells in inflammatory loci. This event is maintained by milk fat globule-EGF factor 8 (MFG-E8), but attenuated by high mobility group box 1 (HMGB1).
Xiao Wang, Heng-Fu Bu, Wei Zhong, Akihiro Asai, Zhanxiang Zhou, Xiao-Di Tan   +5 more
doaj   +1 more source

The clearance of dead cells by efferocytosis

Nature Reviews Molecular Cell Biology, 2020
Multiple modes of cell death have been identified, each with a unique function and each induced in a setting-dependent manner. As billions of cells die during mammalian embryogenesis and daily in adult organisms, clearing dead cells and associated cellular debris is important in physiology.
Emilio Boada-Romero, Jennifer Martinez, Bradlee L. Heckmann, Douglas R. Green   +3 more
openaire   +3 more sources

Nogo-B impairs efferocytosis in monocyte-derived macrophages and exacerbates septic liver injury

JHEP Reports
Background & Aims: Efferocytosis is essential for maintaining tissue homeostasis and resolving inflammation, but this process is compromised during sepsis.
Weizhe Zhong, Jian Xu, Fei Li, Zhu Guan, Haoran Hu, Dongming Wu, Yuechen Wang, Ye Zhang, Yan Bai, Yue Yu, Yun Gao, Ping Wang, Xiongxiong Pan, Zhuqing Rao, Haoming Zhou, Xuehao Wang   +15 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Targeting Efferocytosis in Inflammaging

Annual Review of Pharmacology and Toxicology
Rapid removal of apoptotic cells by phagocytes, a process known as efferocytosis, is key for the maintenance of tissue homeostasis, the resolution of inflammation, and tissue repair. However, impaired efferocytosis can result in the accumulation of apoptotic cells, subsequently triggering sterile inflammation through the release of endogenous factors ...
Poon, Ivan K H, Ravichandran, Kodi S
openaire   +3 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Efferocytosis and Its Associated Cytokines: A Light on Non-tumor and Tumor Diseases?

Molecular Therapy: Oncolytics, 2020
Billions of cells undergo turnover and die via apoptosis throughout our lifetime. A prompt clearance of these apoptotic cells and debris by phagocytic cells, a process known as efferocytosis, is important in maintaining tissue homeostasis.
Danfeng Lin, Xiaodiao Kang, Lu Shen, Sheng Tu, Cameron Lenahan, Yiding Chen, Xiaochen Wang, Anwen Shao   +7 more
doaj   +1 more source

Macrophage‐to‐Myofibroblast Transdifferentiation Contributes to Pulmonary Fibrosis via the MERTK‐SPP1‐SRC‐TKS5 Signaling Axis

Advanced Science, EarlyView.
MERTK is upregulated in fibrotic macrophages and regulates the expression and activity of SRC and TKS5 through SPP1, mediating transdifferentiation of macrophages‐to‐myofibroblasts (MMT) and promoting pulmonary fibrosis. The figure was created with BioRender.com.
Yungeng Wei, Hua Guo, Xiangsheng Yang, Xiao Xiao Tang   +3 more
wiley   +1 more source