Results 11 to 20 of about 11,135 (204)
Efferocytosis in liver diseaseKey points
JHEP ReportsSummary: The process of dead cell clearance by phagocytic cells, called efferocytosis, prevents inflammatory cell necrosis and promotes resolution and repair. Defective efferocytosis contributes to the progression of numerous diseases in which cell death
Hongxue Shi +3 more
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Current Biology, 2016 Kumar and Birge introduce efferocytosis - the process by which dead or dying cells are engulfed and digested by phagocytes.
Sushil, Kumar, Raymond B, Birge
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Cell Communication and Signaling, 2023 Background The inflammatory response induced by intestinal ischaemia‒reperfusion injury (I/R) is closely associated with infectious complications and mortality in critically ill patients, and the timely and effective clearance of apoptotic cells is an ...
Xiao-Hu Zhao +8 more
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Apoptosis recognition receptors regulate skin tissue repair in mice
eLife, 2023 Apoptosis and clearance of apoptotic cells via efferocytosis are evolutionarily conserved processes that drive tissue repair. However, the mechanisms by which recognition and clearance of apoptotic cells regulate repair are not fully understood. Here, we
Olivia Justynski +13 more
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Efferocytosis and autoimmune disease [PDF]
International Immunology, 2018 Abstract An enormous number of cells in the body die by apoptosis during development and under homeostasis. Apoptotic cells are swiftly engulfed by macrophages and digested into units. This removal of apoptotic cells is called ‘efferocytosis’.
Kawano, Mahiru, Nagata, Shigekazu
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Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis
Hepatology, EarlyView., 2022 EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu +16 more
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Efferocytosis in the tumor microenvironment [PDF]
Seminars in Immunopathology, 2018 Within the course of a single minute, millions of cells in the human body will undergo programmed cell death in response to physiological or pathological cues. The diminished energetic capacity of an apoptotic cell renders the cell incapable of sustaining plasma membrane integrity.
Werfel, Thomas A., Cook, Rebecca S.
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Cell Death and Disease, 2023 The efficient clearance of dead and dying cells, efferocytosis, is critical to maintain tissue homeostasis. In the bone marrow microenvironment (BMME), this role is primarily fulfilled by professional bone marrow macrophages, but recent work has shown ...
Emily R. Quarato +11 more
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Efferocytosis and Lung Disease [PDF]
Chest, 2013 In healthy individuals, billions of cells die by apoptosis each day. Clearance of these apoptotic cells, termed "efferocytosis," must be efficient to prevent secondary necrosis and the release of proinflammatory cell contents that disrupt tissue homeostasis and potentially foster autoimmunity.
Alexandra L, McCubbrey +1 more
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Cell Death Discovery, 2023 Aged livers have shown aggravated liver ischemia and reperfusion (IR) injury. Timely efferocytosis of apoptotic cells is a key mechanism for avoiding excessive inflammation and tissue injury.
Haoran Hu +11 more
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