Results 11 to 20 of about 9,881 (141)
Efferocytosis and autoimmune disease [PDF]
International Immunology, 2018 Abstract An enormous number of cells in the body die by apoptosis during development and under homeostasis. Apoptotic cells are swiftly engulfed by macrophages and digested into units. This removal of apoptotic cells is called ‘efferocytosis’.
Kawano, Mahiru, Nagata, Shigekazu
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Efferocytosis in the tumor microenvironment [PDF]
Seminars in Immunopathology, 2018 Within the course of a single minute, millions of cells in the human body will undergo programmed cell death in response to physiological or pathological cues. The diminished energetic capacity of an apoptotic cell renders the cell incapable of sustaining plasma membrane integrity.
Werfel, Thomas A., Cook, Rebecca S.
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The Role of Efferocytosis in Atherosclerosis [PDF]
Circulation, 2017 The necrotic core has long been a hallmark of the vulnerable atherosclerotic plaque. Although apoptotic cells are cleared quickly in almost all other tissue beds, their removal appears to be significantly impaired in the diseased blood vessel. Emerging evidence indicates that this phenomenon is caused by a defect in efferocytosis, the process by which ...
Yoko, Kojima +2 more
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The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
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Efferocytosis and Lung Disease [PDF]
Chest, 2013 In healthy individuals, billions of cells die by apoptosis each day. Clearance of these apoptotic cells, termed "efferocytosis," must be efficient to prevent secondary necrosis and the release of proinflammatory cell contents that disrupt tissue homeostasis and potentially foster autoimmunity.
Alexandra L, McCubbrey +1 more
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Efferocytosis Is an Innate Antibacterial Mechanism [PDF]
Cell Host & Microbe, 2012 Mycobacterium tuberculosis persists within macrophages in an arrested phagosome and depends upon necrosis to elude immunity and disseminate. Although apoptosis of M. tuberculosis-infected macrophages is associated with reduced bacterial growth, the bacteria are relatively resistant to other forms of death, leaving the mechanism underlying this ...
Martin, Constance J. +8 more
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Macrophage Efferocytosis in Heart. [PDF]
Arterioscler Thromb Vasc BiolEfficient clearance of dying cells by efferocytosis is critical for organ development, inflammation resolution, and tissue repair. In the heart, the stakes of efficient clearance are high in that inefficient efferocytosis promotes an inflammatory environment that stresses the health of surrounding ...
Inui H +5 more
europepmc +3 more sources
Efferocytosis of Pathogen-Infected Cells [PDF]
Frontiers in Immunology, 2017 The prompt and efficient clearance of unwanted and abnormal cells by phagocytes is termed efferocytosis and is crucial for organism development, maintenance of tissue homeostasis, and regulation of the immune system. Dying cells are recognized by phagocytes through pathways initiated via "find me" signals, recognition via "eat me" signals and down ...
Karaji, N, Sattentau, Q
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The Role of Efferocytosis in Autoimmune Diseases [PDF]
Frontiers in Immunology, 2018 L'apoptose se produit en continu pour des millions de cellules ainsi que l'élimination active des débris apoptotiques afin de maintenir l'homéostasie tissulaire. À cet égard, l'efférocytose, c'est-à-dire le processus d'élimination des cellules mortes, est orchestrée par l'exposition cellulaire d'un ensemble de signaux « trouve-moi », « mange-moi » et «
Fereshte Abdolmaleki +9 more
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Modulation of Macrophage Efferocytosis in Inflammation [PDF]
Frontiers in Immunology, 2011 A critical function of macrophages within the inflammatory milieu is the removal of dying cells by a specialized phagocytic process called efferocytosis ("to carry to the grave"). Through specific receptor engagement and induction of downstream signaling, efferocytosing macrophages promote resolution of inflammation by (i) efficiently engulfing dying ...
Korns, Darlynn +4 more
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