Results 51 to 60 of about 14,265 (225)

MFG-E8 and HMGB1 Are Involved in the Mechanism Underlying Alcohol-Induced Impairment of Macrophage Efferocytosis

Molecular Medicine, 2013
Efferocytosis is a unique phagocytic process for macrophages to remove apoptotic cells in inflammatory loci. This event is maintained by milk fat globule-EGF factor 8 (MFG-E8), but attenuated by high mobility group box 1 (HMGB1).
Xiao Wang, Heng-Fu Bu, Wei Zhong, Akihiro Asai, Zhanxiang Zhou, Xiao-Di Tan   +5 more
doaj   +1 more source

Broad-spectrum antibiotics disrupt homeostatic efferocytosis [PDF]

The clearance of apoptotic cells, termed efferocytosis, is essential for tissue homeostasis and prevention of autoimmunity 1. Although past studies have elucidated local molecular signals that regulate homeostatic efferocytosis in a tissue 2,3, whether ...
Romero-Pichardo, Jesus E., Josefowicz, Steven Z., Anderson, CJ, Trzeciak, Alissa J., Lipshutz, Allie, O'Neal, Anya J., Perry, Justin S.A., Wang, Zhaoquan, Saitz Rojas, Waleska, Brink, Marcel R. M. van den, Zago, Guilia, Lucas, Christopher D; id_orcid, Liu, Zong-Lin, Saavedra, Pedro H., Daman, Andrew W., Rudensky, Alexander Y.   +15 more
core   +1 more source

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Manganese-Based Polyoxometalate Nanozyme-Metformin Co-functionalized Hydrogel Promotes Diabetic Wound Regeneration by Enhancing Phagocyte Efferocytosis

Research
Efferocytosis, mediated by macrophages and dendritic cells (DCs), clears apoptotic cells to maintain tissue homeostasis, suppress inflammation, and promote repair.
Linfeng Li, Jing Zhang, Caiping Yan, Yongjie Wen, Lifu Jia, Xiyang Tang, Yuan Yong, Ke Jiang, Hanfeng Yang, Lu Chen, Yuling Li   +10 more
doaj   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin, Zhimin Lv, Chao Bian, Qibin Yang, Na Zhou, Jianguang Qin, Shengming Sun   +6 more
wiley   +1 more source

Efferocytosis in Retinoblastoma

Journal of Cancer Therapy, 2013
Retinoblastoma has varied presentations. As age advances in retinoblastoma, the undifferentiated tumour is the common appearance. Apoptosis in retinoblastoma in an untreated case can give us a clue about the tumour biology. Efferocytosis in intraocular tumour is a new concept which was seen in an enucleated eyeball specimen in a 4-year-old boy ...
Dipankar Das, Harsha Bhattacharjee, Kasturi Bhattacharjee, Prerana S. Tahiliani, Pankaj Bhattacharyya, Manabjyoti Barman, Sumita Sarma Barthakur, Panna Deka, Apurba Deka, Rajashree Paul   +9 more
openaire   +2 more sources

Efferocytosis in multisystem diseases (Review)

Molecular Medicine Reports, 2021
Efferocytosis, the phagocytosis of apoptotic cells performed by both specialized phagocytes (such as macrophages) and non‑specialized phagocytes (such as epithelial cells), is involved in tissue repair and homeostasis. Effective efferocytosis prevents secondary necrosis, terminates inflammatory responses, promotes self‑tolerance and activates pro ...
Yifan, Zhang, Yiru, Wang, Jie, Ding, Ping, Liu   +3 more
openaire   +3 more sources

MerTK-mediated efferocytosis promotes immune tolerance and tumor progression in osteosarcoma through enhancing M2 polarization and PD-L1 expression

OncoImmunology, 2022
The poor progress of immunotherapy on osteosarcoma patients requires deeper delineation of immune tolerance mechanisms in the osteosarcoma microenvironment and a new therapeutic strategy.
Jinti Lin, Ankai Xu, Jiakang Jin, Man Zhang, Jianan Lou, Chao Qian, Jian Zhu, Yitian Wang, Zhengming Yang, Xiumao Li, Wei Yu, Bing Liu, Huimin Tao   +12 more
doaj   +1 more source