Results 71 to 80 of about 11,135 (204)

Efferocytosis is impaired in Gaucher macrophages

Haematologica, 2016
Gaucher disease, the inherited deficiency of lysosomal glucocerebrosidase, is characterized by the presence of glucosylceramide-laden macrophages resulting from impaired digestion of aged erythrocytes or apoptotic leukocytes. Studies of macrophages from patients with type 1 Gaucher disease with genotypes N370S/N370S, N370S/L444P or N370S/c.84dupG ...
Elma Aflaki, Daniel K. Borger, Richard J. Grey, Martha Kirby, Stacie Anderson, Grisel Lopez, Ellen Sidransky   +6 more
openaire   +3 more sources

Refining the treatment of immune checkpoint inhibitor–associated myocarditis: Challenges, innovations and rechallenge considerations

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI)‐associated myocarditis has emerged as a severe and clinically complex immune‐related toxicity that poses significant challenges for therapeutic decision‐making in routine cardio‐oncological care. High‐dose corticosteroids remain the first‐line therapy, yet their timing, dosage and tapering require careful clinical ...
Raluca I. Mincu, Lisa Zimmer, Dimitra Vlachopoulou, Elias Haj‐Yehia, Julia Hoffmann, Lars Michel, Elisabeth Livingstone, Dirk Schadendorf, Alpaslan Tasdogan, Matthias Totzeck, Tienush Rassaf   +10 more
wiley   +1 more source

Identification of Seven in absentia homolog 2 as a potential efferocytosis-related biomarker in diabetic foot ulcers.

PLoS ONE
IntroductionWound of diabetic foot ulcers (DFU) is chronic and hard to heal, characterized by impaired inflammatory response, dysfunction of keratinocyte and endothelial cells and improper removal of dying cells. Efferocytosis, as a trigger for phenotype
Jiangli Zhao, Xuchen Liu, Qingyuan Sun, Yanya He, Jiwei Wang, Junzhi Liu, Chao Li, Fei Yan, Haoyong Jin, Zhiwei Xue, Ziyi Tang, Nan Su, Ning Yang, Xinyu Wang   +13 more
doaj   +1 more source

CD93—An emerging vascular target in cancer therapy

British Journal of Pharmacology, EarlyView.
Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira, Stefano Barbera, Roberta Lugano, Anna Dimberg   +3 more
wiley   +1 more source

The role of secreted proteins in efferocytosis

Frontiers in Cell and Developmental Biology
The clearance of apoptotic cells known as efferocytosis is the final stage of apoptosis, and includes the recognition, phagocytosis, and degradation of apoptotic cells. The maintenance of tissue homeostasis requires the daily elimination of billions of apoptotic cells from the human body via the process of efferocytosis.
Guangsheng Hou, Xinyu Wang, Anhua Wang, Lei Yuan, Qian Zheng, Hui Xiao, Hui Wang   +6 more
openaire   +3 more sources

Staphylococcus aureus vesicles impair cutaneous wound healing through p38 MAPK-MerTK cleavage-mediated inhibition of macrophage efferocytosis

Cell Communication and Signaling
Background Staphylococcus aureus, a known contributor to non-healing wounds, releases vesicles (SAVs) that influence the delicate balance of host-pathogen interactions. Efferocytosis, a process by which macrophages clear apoptotic cells, plays a key role
Jiaxin Ou, Kangxin Li, Hui Yuan, Shaohua Du, Tingting Wang, Qiannan Deng, Huimei Wu, Weiyan Zeng, Kui Cheng, Kutty Selva Nandakumar   +9 more
doaj   +1 more source

Efferocytosis: the resolution of inflammation in cardiovascular and cerebrovascular disease

Frontiers in Immunology
Cardiovascular and cerebrovascular diseases have surpassed cancer as significant global health challenges, which mainly include atherosclerosis, myocardial infarction, hemorrhagic stroke and ischemia stroke.
Bingtao Zhang, Yan Zou, Zixuan Yuan, Kun Jiang, Zhaoxiang Zhang, Shujuan Chen, Xiaoming Zhou, Qi Wu, Xin Zhang   +8 more
doaj   +1 more source

ADAM17 and its proteolytic targets in disease pathogenesis

The FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source

Efferocytosis in the Tumor Microenvironment [PDF]

, 2016
Cell death in response to physiological cues is a feature of many normal tissues, and often occurs due to tissue damage or disease. Regardless of the reason, dying cells require their rapid removal from the tissue in order to maintain homeostasis in the tissue, prevent potential cytotoxic immunity against self-antigens, and to promote wound healing ...
D.B. Vaught, J.C. Stanford, R.S. Cook
openaire   +1 more source

Efferocytosis in tissue engineering: A comprehensive review of emerging therapeutic strategies for enhanced tissue repair and regeneration

Bioactive Materials
s: This comprehensive review elucidates the critical role of efferocytosis in tissue repair and regeneration processes, while systematically exploring innovative approaches through which tissue engineering strategies can modulate efferocytosis to ...
Yue-Qi Zhang, Rong Nie, Zi-Yuan Feng, Ming-Hui Fan, Zhi-Xue Shen, Xiu-Zhen Zhang, Qing-Yi Zhang, Chen-Yu Zou, Ji-Ye Zhang, Kai Huang, Li-Ping Mou, Hui-Qi Xie   +11 more
doaj   +1 more source