Results 81 to 90 of about 14,265 (225)

Efferocytosis is an Innate Antibacterial Mechanism of Mycobacterium tuberculosis Control [PDF]

, 2012
One third of the world’s population is infected with Mycobacterium tuberculosis, causing two million deaths annually. The bacteria avoid immune clearance by persisting within macrophages by subverting normal phagosome maturation and acidification.
Martin, Constance
core   +4 more sources

Roles of efferocytosis in wound repair: Process, cells, and signals

Genes and Diseases
Efficient clearance of apoptotic cells, termed efferocytosis, is essential for resolving excessive inflammation, promoting wound repair, and maintaining homeostasis.
Yilin Sun, Haiying Guo, Yang Bai, Jin Chen, Yuhong Li   +4 more
doaj   +1 more source

ERK5 activation in macrophages promotes efferocytosis and inhibits atherosclerosis

, 2014
Background—Efferocytosis is a process by which dead and dying cells are removed by phagocytic cells. Efferocytosis by macrophages is thought to curb the progression of atherosclerosis, but the mechanistic insight of this process is lacking.Methods and ...
Fujiwara, Keigi, Abe, Jun-ichi, Heo, Kyung-Sun, Cushman, Hannah J., Wang, Xin, Woo, Chang-Hoon, Akaike, Masashi   +6 more
core   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Establishment of a novel efferocytosis potential index predicts prognosis and immunotherapy response in cancers

Heliyon
The biological function and prognostic value of efferocytosis in cancer remains unclear. In this study, we systematically analysed the expression profiles and genetic variations of 50 efferocytosis-related regulator genes in 33 cancer types.
Peng Chen, Zhanzhan Li, Na Li
doaj   +1 more source

Crbn modulates calcium influx by regulating Orai1 during efferocytosis

, 2020
Calcium flux regulating intracellular calcium levels is essential and modulated for efficient efferocytosis. However, the molecular mechanism by which calcium flux is modulated during efferocytosis remains elusive.
Susumin Yang, Lee, Gwangrog, Kwanhyeong Kim, Gayoung Kim, Deokhwan Kim, Min, Chanhyuk, Park, Daeho, Lee, Sang-Ah, Lee, Chang Sup, Moon, Hyunji, Byeongjin Moon, Yang, Susumin, Moon, Byeongjin, Kim, Kwanhyeong, Sang-Ah Lee, Kim, Gayoung, Hyunji Moon, Chanhyuk Min, Cho, Steve K., Seung-Joo Yang, Kim, Deokhwan, Yang, Seung-Joo, Juyeon Lee, Chang Sup Lee, Park, Chul-Seung, Lee, Juyeon   +25 more
core   +1 more source

Therapeutic Properties and Underlying Mechanisms of Traditional Chinese Medicine in Managing Rheumatoid Arthritis: An Integrative Review of Clinical and Molecular Findings

Phytotherapy Research, EarlyView.
The translational research framework integrating TCM for RA. The figure outlines a stepwise framework for the modernization and clinical translation of TCM in RA. Part 1 highlights the inheritance and development of TCM theory, including classical medical texts, traditional herbal knowledge, and syndrome differentiation–based treatment principles. Part
Jianting Wen, Jian Liu, Lei Wan, Fanfan Wang, Yang Li   +4 more
wiley   +1 more source

Identification of Seven in absentia homolog 2 as a potential efferocytosis-related biomarker in diabetic foot ulcers.

PLoS ONE
IntroductionWound of diabetic foot ulcers (DFU) is chronic and hard to heal, characterized by impaired inflammatory response, dysfunction of keratinocyte and endothelial cells and improper removal of dying cells. Efferocytosis, as a trigger for phenotype
Jiangli Zhao, Xuchen Liu, Qingyuan Sun, Yanya He, Jiwei Wang, Junzhi Liu, Chao Li, Fei Yan, Haoyong Jin, Zhiwei Xue, Ziyi Tang, Nan Su, Ning Yang, Xinyu Wang   +13 more
doaj   +1 more source

Intersection of systemic lupus erythematosus and autoimmune thyroid disease: Shared pathophysiology, epidemiology, diagnosis, and management

Rheumatology &Autoimmunity, EarlyView.
A proposed mechanistic framework of systemic lupus erythematosus (SLE) and autoimmune thyroid disease (AITD) pathogenesis. In Stage 1, genetically susceptible individuals harbor risk variants within major histocompatibility complex (HLA) and non‐HLA loci that impair central and peripheral immune tolerance mechanisms within the thymic and peripheral ...
Elisa Elisa, Awalia Awalia, Deasy Ardiany, Henry Sutanto   +3 more
wiley   +1 more source

Extracellular Histones Inhibit Efferocytosis

Molecular Medicine, 2012
The uptake and clearance of apoptotic cells by macrophages and other phagocytic cells, a process called efferocytosis, is a major component in the resolution of inflammation. Increased concentrations of extracellular histones are found during acute inflammatory states and appear to contribute to organ system dysfunction and mortality. In these studies,
Arnaud, Friggeri, Sami, Banerjee, Na, Xie, Huachun, Cui, Andressa, De Freitas, Mourad, Zerfaoui, Hervé, Dupont, Edward, Abraham, Gang, Liu   +8 more
openaire   +2 more sources