Results 31 to 40 of about 422,920 (251)
Apoptosis in resolution of inflammation [PDF]
Journal of Leukocyte Biology, 1997 Abstract The last few years have seen the accumulation of compelling evidence that apoptosis (programmed cell death) plays a major role in promoting resolution of the acute inflammatory response. Neutrophils are constitutively programmed to undergo apoptosis, which limits their pro-inflammatory potential and leads to rapid, specific, and
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Inflammation Resolution: Implications for Atherosclerosis [PDF]
Circulation Research, 2022 Resolution is an active and highly coordinated process that occurs in response to inflammation to limit tissue damage and promote repair. When the resolution program fails, inflammation persists. It is now understood that failed resolution is a major underlying cause of many chronic inflammatory diseases.
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Resolvin E1 Regulates Th17 Function and T Cell Activation
Frontiers in Immunology, 2021 Resolvin E1 (RvE1) is a specialized pro-resolving lipid mediator derived from eicosapentaenoic acid and plays a critical role in resolving inflammation and tissue homeostasis. Th17 cells are a distinct group of T helper (Th) cells with tissue-destructive
Fatma Oner +10 more
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Frontiers in Cell and Developmental Biology, 2022 Cyclin-dependent kinase (CDK) inhibitor drugs (CDKi), such as R-roscovitine and AT7519, induce neutrophil apoptosis in vitro and enhance the resolution of inflammation in a number of in vivo models. This class of compounds are potential novel therapeutic
Brian J. McHugh +9 more
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Frontiers in Immunology, 2021 The recent outbreak of SARS-CoV2 has emerged as one of the biggest pandemics of our century, with outrageous health, social and economic consequences globally.
Maria G. Balta +3 more
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Lipid Mediators in the Resolution of Inflammation [PDF]
Cold Spring Harbor Perspectives in Biology, 2014 Mounting of the acute inflammatory response is crucial for host defense and pivotal to the development of chronic inflammation, fibrosis, or abscess formation versus the protective response and the need of the host tissues to return to homeostasis. Within self-limited acute inflammatory exudates, novel families of lipid mediators are identified, named ...
Charles N, Serhan +3 more
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Novel Resolution Mediators of Severe Systemic Inflammation
ImmunoTargets and Therapy, 2020 Verena Gudernatsch, Sylwia Anna Stefańczyk, Valbona Mirakaj Molecular Intensive Care Medicine, Department of Anesthesiology and Intensive Care Medicine, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen ...
Gudernatsch V, Stefańczyk SA, Mirakaj V
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Leukocytes in Inflammation, Resolution of Inflammation, Autoimmune Diseases and Cancer
Cells, 2021 Inflammation is a double-edged sword [...]
János G. Filep
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Resolution of Acute Inflammation in the Lung [PDF]
Annual Review of Physiology, 2014 Acute inflammation in the lung is essential to health. So too is its resolution. In response to invading microbes, noxious stimuli, or tissue injury, an acute inflammatory response is mounted to protect the host. To limit inflammation and prevent collateral injury of healthy, uninvolved tissue, the lung orchestrates the formation of specialized ...
Bruce D, Levy, Charles N, Serhan
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta +6 more
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