Results 1 to 10 of about 3,117 (109)
BiomoleculesPolyunsaturated fatty acids (PUFAs), particularly omega-3 derivatives such as docosahexaenoic acid (DHA), are precursors of specialized pro-resolving mediators (SPMs) that actively orchestrate the resolution of inflammation.
Daniel R Gonzalez +1 more
exaly +4 more sources
Molecules, 2022 Marine organisms are an important source of natural products with unique and diverse chemical structures that may hold the key for the development of novel drugs.
Narcisa Bandarra, Amélia Rauter
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Protective Potential of Maresins in Cardiovascular Diseases
Frontiers in Cardiovascular Medicine, 2022 Cardiovascular diseases are the leading causes of global mortality. Growing evidence suggests that unresolved inflammation contributes to the chronicity, progression and morbidity of many cardiovascular diseases, thus emphasizing the urgent need to ...
Lihong Chen
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Advances in the role of specialized pro-resolving mediators in periodontitis [PDF]
Frontiers in ImmunologyPeriodontitis is a chronic inflammatory disease driven by dysregulated host–microbial interactions and failure of endogenous inflammation resolution, leading to progressive destruction of periodontal tissues.
Huiting Hu +4 more
doaj +2 more sources
Specialized Pro-Resolving Mediators at the Ocular Surface: Biosynthesis, Mechanisms, and Therapeutic Potential [PDF]
BiologySpecialized pro-resolving mediators (SPMs) are endogenous lipid mediators that actively orchestrate the resolution of inflammation rather than relying solely on broad suppression of inflammatory signaling.
Siddharth Gandhi +3 more
doaj +2 more sources
Antioxidants, 2022 Skeletal muscle ischemia reperfusion is very frequent in humans and results not only in muscle destruction but also in multi-organ failure and death via systemic effects related to inflammation and oxidative stress.
Cindy Barnig +2 more
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Resolving Inflammation in CKD: The Potential of SPMs and Omega-3 Derivatives as Biomarkers and Therapeutics [PDF]
BiomedicinesChronic kidney disease (CKD) affects more than 10% of the population and is associated with a persistent, low-grade inflammatory state that accelerates tubulointerstitial fibrosis, worsens prognosis, and increases cardiovascular risk. This review aims to
Beata Franczyk +8 more
doaj +2 more sources
Maresins as novel anti-inflammatory actors and putative therapeutic targets in sepsis
Pharmacological ResearchSepsis, a complex clinical syndrome characterized by an exaggerated host response to infection, often necessitates hospitalization and intensive care unit admission. Delayed or inaccurate diagnosis of sepsis, coupled with suboptimal treatment strategies,
Yun Lin
exaly +3 more sources
Mediators of Inflammation, 2018 Acute inflammatory responses are host-protective and normally self-limited; these responses can maintain cell homeostasis and promote defense against various infections and damage factors.
Yong Xu, Shi Tang, Yong Xu
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Macrophages: their role in immunity and their relationship with fatty acids in health and disease [PDF]
Frontiers in ImmunologyThe intricate interplay between macrophage biology and lipid metabolism has emerged as a critical determinant of metabolic homeostasis, disease progression and pathogenesis.
Mayte Rueda-Munguía +9 more
doaj +2 more sources