Journal of Pain Research, 2018 Jie Gao,1,2,* Chaoliang Tang,3,4,* Lydia Wai Tai,5 Yeling Ouyang,2,6 Na Li,2,6 Zhiqiang Hu,2,6 Xiangdong Chen2,6 1Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui Provence, China; 2Department ...
Gao J +6 more
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BiomoleculesPolyunsaturated fatty acids (PUFAs), particularly omega-3 derivatives such as docosahexaenoic acid (DHA), are precursors of specialized pro-resolving mediators (SPMs) that actively orchestrate the resolution of inflammation. Among these, maresins (MaRs) have gathered increasing attention due to their potent immunomodulatory and tissue-regenerative ...
Berrocal-Navarrete F +6 more
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Omega-3 DHA as a blank canvas: A molecular approximation to how lipid mediators modulate LGR6 in inflammation resolution. [PDF]
Protein SciAbstract The leucine‐rich repeat‐containing G protein‐coupled receptor 6 (LGR6) has a potential role in inflammation resolution and different cancer processes. In this study, we employed computational techniques, including molecular docking and molecular dynamics simulations of mammalian membrane‐embeded systems, to understand the activation mechanism ...
Pérez-Sánchez Á +3 more
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Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions [PDF]
The Journal of Clinical Investigation, 2023 Resolution of acute inflammation is an active process orchestrated by endogenous mediators and mechanisms pivotal in host defense and homeostasis. The macrophage mediator in resolving inflammation, maresin 1 (MaR1), is a potent immunoresolvent, stimulating resolution of acute inflammation and organ protection.
Nan Chiang +4 more
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Beyond Symptom Suppression: The Multitargeted Reversal of Chronic Pain by Maresin1. [PDF]
Drug Des Devel TherWang F, Yang Y, Wang W, Shi Q, Fan B.
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Maresin-1 Alleviates Sepsis-Induced Liver Injury by Regulating Apoptosis and Autophagy via Activation of the PI3K/Akt Signaling Pathway in Mice. [PDF]
Curr Issues Mol BiolWang H, Sun M, Fan H.
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Maresin 1 activates autophagy through SIRT1/PPAR-γ signaling to mitigate high glucose-induced pyroptosis in human retinal pigment epithelial cells. [PDF]
Exp Ther MedZhang J +5 more
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Serum Resolvin D1 and Maresin 1 Levels During Migraine Attacks and the Interictal Period: A Paired Analysis in Emergency Department Patients. [PDF]
BiomedicinesKoç M +2 more
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Specialized pro-resolving mediators alleviate inflammation and cartilage breakdown in vitro and may play a pivotal role in platelet-rich plasma. [PDF]
Sci RepLeite CBG +8 more
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Renal transcriptome-wide analyses in association with kidney black carbon load. [PDF]
Part Fibre ToxicolRasking L +7 more
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