Results 31 to 40 of about 209 (125)

Maresin 1 Attenuates Lipopolysaccharide-Induced Acute Kidney Injury via Inhibiting NOX4/ROS/NF-κB Pathway

Frontiers in Pharmacology, 2021
Sepsis-associated acute kidney injury (S-AKI) is a common complication in hospitalized and critically ill patients, which increases the risk of multiple comorbidities and is associated with extremely high mortality.
Jiameng Li, Zhuyun Zhang, Liya Wang, Luojia Jiang, Zheng Qin, Yuliang Zhao, Baihai Su   +6 more
doaj   +1 more source

Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions [PDF]

Journal of Experimental Medicine, 2008
The endogenous cellular and molecular mechanisms that control acute inflammation and its resolution are of wide interest. Using self-resolving inflammatory exudates and lipidomics, we have identified a new pathway involving biosynthesis of potent antiinflammatory and proresolving mediators from the essential fatty acid docosahexaenoic acid (DHA) by ...
Serhan, Charles N., Yang, Rong, Martinod, Kimberly, Kasuga, Kie, Pillai, Padmini S., Porter, Timothy F., Oh, Sungwhan F., Spite, Matthew   +7 more
openaire   +4 more sources

EICOSANOIDS AND INFLAMMATION

Современная ревматология, 2016
Inflammation is the most important element in the pathogenesis of major human diseases. It determines the fundamental value of anti-inflammatory therapy in the modern concept of targeted pathogenetic treatment.
A. E. Karateev, T. L. Aleinikova
doaj   +1 more source

DHA- and EPA-derived resolvins, protectins, and maresins in airway inflammation [PDF]

European Journal of Pharmacology, 2016
Essential fatty acids can serve as important regulators of inflammation. A new window into mechanisms for the resolution of inflammation was opened with the identification and structural elucidation of mediators derived from these fatty acids with pro-resolving capacity.
Melody G, Duvall, Bruce D, Levy
openaire   +2 more sources

The Role of Maresins in Inflammatory Pain: Function of Macrophages in Wound Regeneration [PDF]

International Journal of Molecular Sciences, 2019
Although acute inflammatory responses are host-protective and generally self-limited, unresolved and delayed resolution of acute inflammation can lead to further tissue damage and chronic inflammation. The mechanism of pain induction under inflammatory conditions has been studied extensively; however, the mechanism of pain resolution is not fully ...
Sung-Min Hwang, Gehoon Chung, Yong Ho Kim, Chul-Kyu Park   +3 more
openaire   +2 more sources

Maresins: anti-inflammatory pro-resolving mediators with therapeutic potential.

European review for medical and pharmacological sciences, 2020
Although inflammation is protective of the body, uncontrolled acute inflammatory reactions may inflict tissue damage and lead to chronic inflammation. There is a fast-growing research interest in mechanisms that mediate regression of inflammation and actions of anti-inflammatory factors.
Li, Q.-F., Hao, H., Tu, W.-S., Guo, N., Zhou, X.-Y.   +4 more
openaire   +2 more sources

Maresins

Biomolecules
Polyunsaturated fatty acids (PUFAs), particularly omega-3 derivatives such as docosahexaenoic acid (DHA), are precursors of specialized pro-resolving mediators (SPMs) that actively orchestrate the resolution of inflammation. Among these, maresins (MaRs) have gathered increasing attention due to their potent immunomodulatory and tissue-regenerative ...
Fernanda Berrocal-Navarrete, Paz Marín-Sanhueza, Ramón Norambuena-González, Matías Quiñones San Martín, Francisca Herrera-Vielma, Daniel R. González, Jessica Zúñiga-Hernández   +6 more
openaire   +2 more sources

Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance We recently uncovered a family of macrophage-derived molecules, coined maresin conjugates in tissue regeneration, that regulate the system’s ability to clear bacteria as well as repair and regenerate damaged tissues. In the present study, we identified enzymes involved in the formation of these potent molecules in human ...
Dalli, Jesmond, Vlasakov, Iliyan, Riley, Ian R., Rodriguez, Ana R., Spur, Bernd W., Petasis, Nicos A., Chiang, Nan, Serhan, Charles N.   +7 more
openaire   +4 more sources

Maresin conjugates in tissue regeneration-1 suppresses ferroptosis in septic acute kidney injury

Cell & Bioscience, 2021
Background Ferroptosis is unique among different types of regulated cell death and closely related to organ injury. Whether ferroptosis occurs in sepsis-associated acute kidney injury (SA-AKI) is not clear.
Ji Xiao, Qian Yang, Ye’an Zhang, Haoran Xu, Yang Ye, Linchao Li, Yi Yang, Shengwei Jin   +7 more
doaj   +1 more source

Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia

Neural Regeneration Research
Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer’s disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer’s disease to prevent/stop ...
Ying Wang, Xiang Zhang, Henrik Biverstål, Nicolas G. Bazan, Shuai Tan, Nailin Li, Makiko Ohshima, Marianne Schultzberg, Xiaofei Li   +8 more
doaj   +1 more source