Serum biomarker screening and metabolic profiling analysis of nonalcoholic fatty liver disease patients using untargeted metabolomics and machine learning techniques [PDF]
Frontiers in Molecular BiosciencesBackground and ObjectiveNon-alcoholic fatty liver disease (NAFLD) represents the most prevalent chronic hepatic metabolic disorder globally. Without timely intervention, it can progress to non-alcoholic steatohepatitis (NASH), liver fibrosis, and even ...
Lijuan Dan +11 more
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Maresin-1 Ameliorates Chronic Unpredictable Stress-Induced Depressive-like Behaviors Associated with Dynamic Modulation of Hippocampal Microglial Activity and TSPO PET Signals [PDF]
BiomedicinesBackground/Objectives: Maresin-1 (MaR1), a specialized pro-resolving mediator (SPM) derived from omega-3 fatty acids, has demonstrated potent anti-inflammatory and pro-resolving properties.
Anhai Zheng +7 more
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Maresin 1 alleviates myocardial ischemia-reperfusion injury in rats by suppressing inflammation [PDF]
European Journal of HistochemistryMyocardial ischemia-reperfusion injury (MIRI) induces severe inflammatory damage to cardiac tissue, leading to structural impairment and functional decline.
Hongkai Xiao +5 more
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Maresin-1 suppresses imiquimod-induced skin inflammation by regulating IL-23 receptor expression
Scientific Reports, 2018 The anti-inflammatory effect of omega 3 polyunsaturated fatty acids has been confirmed in various inflammatory disease models. Maresin-1 (MaR1) is a lipid mediator derived from the omega-3 fatty acid docosahexaenoic acid (DHA) that has displayed strong ...
Natsuko Saito-Sasaki +8 more
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Circulating Maresin-1 and cartilage remodeling biomarkers in rheumatoid arthritis and osteoarthritis [PDF]
Scientific ReportsRheumatoid arthritis (RA) and osteoarthritis (OA) are prevalent chronic joint diseases characterized by persistent inflammation, progressive cartilage degeneration, and impaired tissue repair mechanisms.
Omer Esmez +5 more
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Drug Design, Development and Therapy, 2019 Yun Qiu, Yichen Wu, Hongmei Zhao, Hong Sun, Sumin Gao Department of Emergency Medicine, The Affiliated Huaian No 1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu Province, China Background: Inflammation and oxidative ...
Qiu Y, Wu Y, Zhao H, Sun H, Gao S
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Maresin 1 induces resolution of hepatic fibrosis through RORα-dependent reprogramming of resident macrophages [PDF]
Frontiers in PharmacologyHepatic fibrosis is a progressive pathological condition characterized by chronic inflammation and excessive extracellular matrix deposition (ECM), which may progress to cirrhosis and liver failure. Although specialized pro-resolving lipid mediators have
Francisca Herrera Vielma +13 more
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Maresin‐1 ameliorates hypertensive vascular remodeling through its receptor LGR6
MedCommHypertensive vascular remodeling is defined as the changes in vascular function and structure induced by persistent hypertension. Maresin‐1 (MaR1), one of metabolites from Omega‐3 fatty acids, has been reported to promote inflammation resolution in ...
Zheng Yin +12 more
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Journal of Pain Research, 2018 Jie Gao,1,2,* Chaoliang Tang,3,4,* Lydia Wai Tai,5 Yeling Ouyang,2,6 Na Li,2,6 Zhiqiang Hu,2,6 Xiangdong Chen2,6 1Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui Provence, China; 2Department ...
Gao J +6 more
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Frontiers in Medicine, 2022 Background: Maresin 1 plays a role in the regulation of inflammation and metabolic diseases in vivo. An increasing number of studies have reported that postmenopausal osteoporosis (PMOP) is associated with inflammation.
Jing Wu +21 more
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