Results 41 to 50 of about 2,016 (189)
Omega 3 Fatty Acid and Skin Diseases
Frontiers in Immunology, 2021 Humans are exposed to various external environmental factors. Food intake is one of the most influential factors impacting daily lifestyle. Among nutrients obtained from foods, omega-3 polyunsaturated fatty acids (PUFAs) have various beneficial effects ...
Yu Sawada +2 more
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Journal of Lipid Research, 2023 A characteristic fragmentation was observed for PUFAs that contain allylic vicinal diol groups (resolvin D1, D2, D4, E3, lipoxin A4, B4, and maresin 2), which were derivatized with N,N-dimethylethylenediamine (DMED), in positive-ion ESI-MS/MS.
Huibin Zhu +5 more
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Biomolecules, 2022 A precision medicine approach is widely acknowledged to yield more effective therapeutic strategies in the treatment of patients with chronic inflammatory conditions than the prescriptive paradigm currently utilized in the management and treatment of ...
Jesmond Dalli +2 more
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International Journal of Molecular Sciences, 2022 Specialized pro-resolving mediators (SPMs), including Maresins (MaR)-1 and 2, contribute to tear film homeostasis and resolve conjunctival inflammation. We investigated MaR2′s signaling pathways in goblet cells (GC) from rat conjunctiva. Agonist-induced [Ca2+]i and high-molecular weight glycoconjugate secretion were measured. MaR2 increased [Ca2+]i and
Markus V. Olsen +6 more
openaire +2 more sources
Southern Clinics of Istanbul Eurasia, 2020 INTRODUCTION[|]The purpose of this study is to examine the protective effects of maresin 1 on testicular injury induced by ischemia reperfusion. [¤]METHODS[|]24 Sprague-Dawley male rats were divided into 3 groups. The groups are planned as follows; sham,
Ayhan Tanyeli +6 more
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Major Structure–Activity Relationships of Resolvins, Protectins, Maresins and Their Analogues
Future Medicinal Chemistry, 2022 Resolvins, protectins and maresins are a series of polyunsaturated fatty acid-derived molecules which play important roles in the resolution of inflammation. They are termed specialized proresolving mediators and facilitate a return to homeostasis following an inflammatory response.
Kevin Daly +2 more
openaire +3 more sources
Frontiers in Psychiatry, 2020 Inflammation has been identified as one of the main pathophysiological mechanisms underlying neuropsychiatric and neurodegenerative disorders. Despite the role of inflammation in those conditions, there is still a lack of effective anti-inflammatory ...
Juliette Giacobbe +4 more
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Cells, 2022 An interconnection between tissue inflammation and regeneration has been established through the regulation of defense and repair mechanisms within diseased dental tissue triggered by the release of immune-resolvent mediators. To better our understanding
Shahd AlZahrani +4 more
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Stereoselective Synthesis of Maresin-Like Lipid Mediators [PDF]
Synlett, 2019 14S,22-Dihydroxy-docosa-4Z,7Z,10Z,12E,16Z,19Z-hexaenoic acid (maresin-L1) and 14R,22-dihydroxy-docosa-4Z,7Z,10Z, 12E,16Z,19Z-hexaenoic acid (maresin-L2) were chemically synthesized. They were identical to activated macrophage-produced counterparts and their total synthesis was highly stereoselective, as revealed by chiral LC-UV-MS/MS analysis.
Song Hong +8 more
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Journal of Lipid Research, 2020 The two oxylipins 7S,14S-dihydroxydocosahexaenoic acid (diHDHA) and 7S,17S-diHDHA [resolvin D5 (RvD5)] have been found in macrophages and infectious inflammatory exudates and are believed to function as specialized pro-resolving mediators (SPMs).
Steven C. Perry +8 more
doaj +1 more source