Results 1 to 10 of about 6,979 (181)

The Anti-Aggregative Potential of Resolvin E1 on Human Platelets

Molecules, 2023
Resolvin E1 is a metabolite of eicosapentaenoic acid (EPA) which is one of the omega-3 polyunsaturated fatty acids (omega-3 PUFAs). The antiplatelet properties of omega-3 PUFAs are well known, but the effect of resolvin E1 on platelets via the collagen ...
Patrycja Szymanska, Boguslawa Luzak, Katarzyna Milowska   +2 more
exaly   +3 more sources

Protective Effect of Resolvin D1, D2, and Their Methyl Esters on Oxidative Stress and Hyaluronidase—Induced Hyaluronic Acid Degradation [PDF]

Antioxidants
Hyaluronic acid (HA) injections are commonly employed in the management of osteoarthritis (OA), yet their therapeutic benefits are often limited by oxidative degradation and enzymatic breakdown within the joint.
Zahra Kariminezhad, Mahdi Rahimi, Julio Fernandes, Hassan Fahmi, Mohamed Benderdour   +4 more
doaj   +2 more sources

Evaluation of the Effects of Lipoxin A4 and Resolvin D1 on the Severity of Transient Tachypnea of the Newborn: A Prospective Study [PDF]

Children
Objective: Transient tachypnea of the newborn (TTN) is a common condition observed in neonates. Since its management often requires intensive care and leads to maternal–infant separation, it is a major source of parental concern.
Emrah Çığrı, Funda Çatan İnan, Sedat Gülten, Mehmet Akif Bildirici, Ayşe Ece Gökkaya, Metin Asıleren, Fethiye Yıldız, Hilmi Onur Kabukcu   +7 more
doaj   +2 more sources

Resolvin E3 attenuates lipopolysaccharide-induced depression-like behavior in mice

Journal of Pharmacological Sciences, 2018
Eicosapentaenoic acid (EPA)-derived resolvin E1 (RvE1) and E2 (RvE2) have antidepressant effects. Here, we investigated the antidepressant effects of resolvin E3 (RvE3) in a mouse model of lipopolysaccharide (LPS)-induced depression. We observed that LPS
Satoshi Deyama, Hayato Fukuda, Satoshi Shuto   +2 more
exaly   +3 more sources

Role of Resolvins in Inflammatory and Neuropathic Pain

Pharmaceuticals, 2023
Chronic pain is an unpleasant experience associated with actual or potential tissue damage. Inflammatory pain alerts the body to inflammation and promotes healing; however, unresolved inflammation can lead to chronic pain.
Jaeik Park, Jueun Roh, Jingying Pan, Yong Ho Kim, Chul-Kyu Park, Youn Yi Jo   +5 more
doaj   +3 more sources

The mechanisms of specialized pro-resolving mediators in pain relief: neuro-immune and neuroglial regulations [PDF]

Frontiers in Immunology
Chronic pain remains a significant global health challenge. Current anti-nociceptive therapies often fail to provide adequate relief and are associated with adverse side effects, underscoring the need for novel therapeutic approaches.
Yushan Chen, Yushan Chen, Xuewei Wu, Jiaqi Li, Yuxuan Ren, He Miao, Xiaojie Zhai, Changshun Huang, Xiaowei Chen, Xiaowei Chen   +9 more
doaj   +2 more sources

Immunological response and tissue loss in a rodent model of chronic traumatic brain injury treated with resolvin [PDF]

Journal of Inflammation
Background Traumatic brain injury (TBI) triggers neuroinflammation both acutely and chronically, the latter which might be involved in neurodegenerative disorders.
Olivia Kiwanuka, Julie Cheung, Anders Hånell, Caroline Lindblad   +3 more
doaj   +2 more sources

Resolvin D1 attenuates sepsis induced acute kidney injury targeting mitochondria and NF-κB signaling pathway

Heliyon, 2022
Background: Acute kidney injury is a highly common and multifactorial renal disease resulting in significant morbidity and mortality, especially sepsis-induced acute kidney injury.
Liya Wang, Jiameng Li, Ruoxi Liao, Yupei Li, Luojia Jiang, Zhuyun Zhang, Jiwen Geng, Ping Fu, Baihai Su, Yuliang Zhao   +9 more
doaj   +1 more source

Protective role of resolvin D1, a pro-resolving lipid mediator, in nonsteroidal anti-inflammatory drug-induced small intestinal damage.

PLoS ONE, 2021
Resolvin D1, a specialized pro-resolving lipid mediator produced from docosahexaenoic acid by 15- and 5-lipoxygenase, exerts anti-inflammatory effects driving to the resolution of inflammation.
Takuya Kuzumoto, Tetsuya Tanigawa, Akira Higashimori, Hiroyuki Kitamura, Yuji Nadatani, Koji Otani, Shusei Fukunaga, Shuhei Hosomi, Fumio Tanaka, Noriko Kamata, Yasuaki Nagami, Koichi Taira, Toshio Watanabe, Yasuhiro Fujiwara   +13 more
doaj   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source