High-intensity swimming alleviates nociception and neuroinflammation in a mouse model of chronic post-ischemia pain by activating the resolvin E1-chemerin receptor 23 axis in the spinal cord [PDF]
Neural Regeneration Research, 2023 Physical exercise effectively alleviates chronic pain associated with complex regional pain syndrome type-I. However, the mechanism of exercise-induced analgesia has not been clarified.
Xin Jia +5 more
doaj +2 more sources
The Anti-Aggregative Potential of Resolvin E1 on Human Platelets
Molecules, 2023 Resolvin E1 is a metabolite of eicosapentaenoic acid (EPA) which is one of the omega-3 polyunsaturated fatty acids (omega-3 PUFAs). The antiplatelet properties of omega-3 PUFAs are well known, but the effect of resolvin E1 on platelets via the collagen ...
Patrycja Szymanska +2 more
exaly +3 more sources
Protective Effect of Resolvin D1, D2, and Their Methyl Esters on Oxidative Stress and Hyaluronidase—Induced Hyaluronic Acid Degradation [PDF]
AntioxidantsHyaluronic acid (HA) injections are commonly employed in the management of osteoarthritis (OA), yet their therapeutic benefits are often limited by oxidative degradation and enzymatic breakdown within the joint.
Zahra Kariminezhad +4 more
doaj +2 more sources
Evaluation of the Effects of Lipoxin A4 and Resolvin D1 on the Severity of Transient Tachypnea of the Newborn: A Prospective Study [PDF]
ChildrenObjective: Transient tachypnea of the newborn (TTN) is a common condition observed in neonates. Since its management often requires intensive care and leads to maternal–infant separation, it is a major source of parental concern.
Emrah Çığrı +7 more
doaj +2 more sources
Resolvin E3 attenuates lipopolysaccharide-induced depression-like behavior in mice
Journal of Pharmacological Sciences, 2018 Eicosapentaenoic acid (EPA)-derived resolvin E1 (RvE1) and E2 (RvE2) have antidepressant effects. Here, we investigated the antidepressant effects of resolvin E3 (RvE3) in a mouse model of lipopolysaccharide (LPS)-induced depression. We observed that LPS
Satohsi Shuto +2 more
exaly +3 more sources
The mechanisms of specialized pro-resolving mediators in pain relief: neuro-immune and neuroglial regulations [PDF]
Frontiers in ImmunologyChronic pain remains a significant global health challenge. Current anti-nociceptive therapies often fail to provide adequate relief and are associated with adverse side effects, underscoring the need for novel therapeutic approaches.
Yushan Chen +9 more
doaj +2 more sources
Immunological response and tissue loss in a rodent model of chronic traumatic brain injury treated with resolvin [PDF]
Journal of InflammationBackground Traumatic brain injury (TBI) triggers neuroinflammation both acutely and chronically, the latter which might be involved in neurodegenerative disorders.
Olivia Kiwanuka +3 more
doaj +2 more sources
Heliyon, 2022 Background: Acute kidney injury is a highly common and multifactorial renal disease resulting in significant morbidity and mortality, especially sepsis-induced acute kidney injury.
Liya Wang +9 more
doaj +1 more source
PLoS ONE, 2021 Resolvin D1, a specialized pro-resolving lipid mediator produced from docosahexaenoic acid by 15- and 5-lipoxygenase, exerts anti-inflammatory effects driving to the resolution of inflammation.
Takuya Kuzumoto +13 more
doaj +1 more source
Resolvin E1 Regulates Th17 Function and T Cell Activation
Frontiers in Immunology, 2021 Resolvin E1 (RvE1) is a specialized pro-resolving lipid mediator derived from eicosapentaenoic acid and plays a critical role in resolving inflammation and tissue homeostasis. Th17 cells are a distinct group of T helper (Th) cells with tissue-destructive
Fatma Oner +10 more
doaj +1 more source