Insights in diabetes: Molecular mechanisms-Protectin DX, an anti-inflammatory and a stimulator of inflammation resolution metabolite of docosahexaenoic acid, protects against the development of streptozotocin-induced type 1 and type 2 diabetes mellitus in male Swiss albino mice [PDF]
Frontiers in Endocrinology, 2023 Our previous studies revealed that certain endogenous low molecular weight lipids have potent anti-diabetic actions. Of all, arachidonic acid (AA) and its anti-inflammatory and inflammation resolving metabolite lipoxin A4 (LXA4) are the most potent anti ...
Undurti N Das, Das Undurti N
exaly +4 more sources
Frontiers in Microbiology, 2020 Metabolites are thought as the end products in cellular regulatory processes and their levels show the strongest relationships with the phenotype. Previously, we showed that the administration of Clostridium butyricum MIYAIRI 588 (CBM 588) upregulated ...
Tadashi Ariyoshi +2 more
exaly +3 more sources
Herring roe PLs promote SPM biosynthesis in macrophages and a keratinocyte/fibroblast coculture as a model of psoriasis [PDF]
Journal of Lipid ResearchPsoriasis is a chronic immune-mediated inflammatory disease affecting the skin, presenting with both local and systemic inflammation as part of its pathophysiology.
Thomas A. Ringheim-Bakka +9 more
doaj +2 more sources
The potential role of n-3 fatty acids and their lipid mediators on asthmatic airway inflammation [PDF]
Frontiers in ImmunologyAsthma, is a common, significant and diverse condition marked by persistent airway inflammation, with a major impact on human health worldwide. The predisposing factors for asthma are complex and widespread.
Yuan Tian +3 more
doaj +2 more sources
Bioactive lipid mediator class switching regulates myogenic cell progression and muscle regeneration [PDF]
Nature CommunicationsThe muscle stem cell niche is well-described as influencing myogenic cell fate decision; however, the intrinsic mechanisms driving muscle stem cell progression during myogenesis are not yet fully elucidated.
Paul Fabre +11 more
doaj +2 more sources
Circulating Protectin D1 and Neutrophils Extracellular Traps in the Diagnosis and Progression of Acute Pancreatitis [PDF]
Journal of Inflammation ResearchZhiyang Wu,1,* Wenjun Lu,2,* Xin Zhang,1 Qiaoying Xia,2 Han Zuo,2 Xi Guo,1 Yu Liu,1 Fan Zhang,3 Xin Zhang,4 Luyao Zhang2 1Department of Critical Care Medicine, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao ...
Wu Z +9 more
doaj +2 more sources
Omega 3 Fatty Acid and Skin Diseases
Frontiers in Immunology, 2021 Humans are exposed to various external environmental factors. Food intake is one of the most influential factors impacting daily lifestyle. Among nutrients obtained from foods, omega-3 polyunsaturated fatty acids (PUFAs) have various beneficial effects ...
Yu Sawada +2 more
doaj +1 more source
Author Correction: Protectin DX increases alveolar fluid clearance in rats with lipopolysaccharide-induced acute lung injury [PDF]
Experimental and Molecular MedicineXiao-Jun Zhuo +9 more
doaj +2 more sources
The biosynthetic pathways of the protectins
Prostaglandins & Other Lipid Mediators, 2023 Evidence for the biosynthetic pathways of the specialized pro-resolving mediator (SPM) protectin D1 (PD1) and its biochemical further local metabolism were presented during the 8th European Workshop on Lipid Mediators, organized June 29th-July 1st, 2022, in Stockholm, Sweden. Herein, we provide an extended and detailed discussion of these topics.
Åsmund Stenvik Haatveit +1 more
openaire +2 more sources
Biomolecules, 2022 A precision medicine approach is widely acknowledged to yield more effective therapeutic strategies in the treatment of patients with chronic inflammatory conditions than the prescriptive paradigm currently utilized in the management and treatment of ...
Jesmond Dalli +2 more
doaj +1 more source