Results 1 to 10 of about 404 (118)

Platelet‐Rich Plasma Combined with Alendronate Reduces Pain and Inflammation in Induced Osteoarthritis in Rats by Inhibiting the Nuclear Factor‐Kappa B Signaling Pathway

BioMed Research International, Volume 2020, Issue 1, 2020., 2020
Purpose. Osteoarthritis (OA) is one of the common degenerative diseases of the joint in the world. This study was designed to explore the effect of platelet‐rich plasma (PRP) combined with alendronate (ALN) on OA. Methods. We induced OA model by anterior cruciate ligament transection (ACLT) method in rats and treating chondrocytes by IL‐1β in vitro ...
Feng Xin, Haihong Wang, Feng Yuan, Yunzhi Ding, Christina Pabelick   +4 more
wiley   +1 more source

Characterization and biological effects of di-hydroxylated compounds deriving from the lipoxygenation of ALA

Journal of Lipid Research, 2013
We have recently described a di-hydroxylated compound called protectin DX (PDX) which derives from docosahexaenoic acid (DHA) by double lipoxygenation.
Miao Liu, Ping Chen, Evelyne Véricel, Moreno Lelli, Laetitia Béguin, Michel Lagarde, Michel Guichardant   +6 more
doaj   +1 more source

Protectin DX attenuates LPS-induced inflammation and insulin resistance in adipocytes via AMPK-mediated suppression of the NF-κB pathway [PDF]

American Journal of Physiology-Endocrinology and Metabolism, 2018
Several studies have demonstrated that protectins, ω-3 fatty acid-derived proresolution mediators, may ameliorate inflammation. Recently, protectin DX (PDX) was also reported to attenuate inflammation and insulin resistance in several cell types. However, the effects of PDX on inflammation in adipocytes remain ambiguous.
Abd El-Aty, A. M., Jeong, Ji Hoon, Jung, Tae Woo, Chung, Yoon Hee, Kim, Hyoung-Chun   +4 more
openaire   +3 more sources

Defining the Intestinal eCBome and Oxylipin Signaling Systems in a TDP‐43 Mouse Model of Frontotemporal Dementia

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
TDP‐43 overexpressing mice, a genetic model of frontotemporal dementia, exhibit dramatic changes in their small intestinal endocannabinoidome members, in terms of both altered concentrations of lipid mediators and expression of some of their receptors (Cnr1, Gpr119, Gpr55, Pparg) and metabolic enzymes (Napepld, Faah). Also, the levels of some oxylipins
Hayatte‐Dounia Mir, Giada Giorgini, Irene Santos‐García, Elizabeth Dumais, Carmen Rodríguez‐Cueto, Eva de Lago, Cristoforo Silvestri, Nicolas Flamand, Javier Fernández‐Ruiz, Vincenzo Di Marzo   +9 more
wiley   +1 more source

Causal Relationship Between Circulating Omega‐3 Fatty Acid and Cerebral Small Vessel Disease: A Mendelian Randomization Study

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
This Mendelian randomization study demonstrated that higher circulating omega‐3 fatty acid levels were causally associated with a modest reduction in risk of cerebral microbleeds (CMB). No significant associations were observed for other CSVD phenotypes, including WMH, LS, and WMPVS.
Yaodan Zhang, Lingxue Gong, Xinmin Deng, Jingtao Liang, Xiaofeng Lv, Rui Lai, Meijun Liu   +6 more
wiley   +1 more source

Establishment and Evaluation of Cell Models for Bronchopulmonary Dysplasia: Challenges and Prospects

The Clinical Respiratory Journal, Volume 19, Issue 8, August 2025.
Bronchopulmonary dysplasia (BPD) is a chronic lung disease affecting preterm infants, with in vitro models offering insights into its causes and treatments. This review covers methods for creating and evaluating these models, discussing their use in drug testing and biological research, and analyzing the advantages and disadvantages of different models.
Zhenzhuang Zou, Li Fu, Jiaying Liu, Bo Huang   +3 more
wiley   +1 more source

An Optimized Ex Vivo n–3 PUFA Supplementation Strategy for Primary Human Macrophages Shows That DHA Suppresses Prostaglandin E2 Formation

Molecular Nutrition &Food Research, Volume 69, Issue 1, January 2025.
This presented ex vivo n–3 polyunsaturated fatty acid (PUFA) supplementation strategy is an important tool for the mechanistic investigation of n–3 PUFA mediated effects in human immune cells. Fatty acid (FA) pattern from monocytes derived from subjects with a low n–3 PUFA status was shifted toward one reflecting the pattern of subjects with a high n–3
Rebecca Kirchhoff, Nadja Kampschulte, Carina Rothweiler, Nadine Rohwer, Karsten‐Henrich Weylandt, Nils Helge Schebb   +5 more
wiley   +1 more source

Expert consensus report on lipid mediators: Role in resolution of inflammation and muscle preservation

The FASEB Journal, Volume 38, Issue 10, 31 May 2024.
Abstract This meeting report presents a consensus on the biological aspects of lipid emulsions in parenteral nutrition, emphasizing the unanimous support for the integration of lipid emulsions, particularly those containing fish oil, owing to their many potential benefits beyond caloric provision. Lipid emulsions have evolved from simple energy sources
Charles N. Serhan, Magnus Bäck, Valerio Chiurchiù, Martin Hersberger, Bettina Mittendorfer, Philip C. Calder, Dan L. Waitzberg, Christian Stoppe, Stanislaw Klek, Robert G. Martindale, the International Lipids in Parenteral Nutrition Summit 2022 Experts, Philip Calder, Sarah Cogle, Valerio Chiurchiù, David Evans, Leah Gramlich, Martin Hersberger, Stanislaw Klek, Robert Martindale, Stephen McClave, Bettina Mittendorfer, Manpreet Mundi, Maurizio Muscaritoli, Reid Nishikawa, Jayshil Patel, Lorenzo Pradelli, Martin Rosenthal, Charles Serhan, Christian Stoppe, Kelly Tappenden, Dan Waitzberg, Malissa Warren, Paul Wischmeyer   +32 more
wiley   +1 more source

Protectin DX alleviates lumbar radicular pain in rats by suppressing RIP3/MLKL-associated necroinflammation through restoration of autophagic function

Frontiers in Pharmacology
BackgroundLumbar radicular pain (LRP) is a prevalent neuropathic pain disorder driven by nucleus pulposus (NP)-induced inflammation. Protectin DX (PDX), a novel specialized pro-resolving lipid mediator (SPM), exerts pro-resolving and analgesic effects in
Qing-xiang Zhao, Xiao-juan Wu, Qing Yao, Yong Gao   +3 more
doaj   +1 more source

Deducing formation routes of oxylipins by quantitative multiple heart-cutting achiral-chiral 2D-LC-MS

Journal of Lipid Research
Several oxylipins are regulators of inflammation. They are formed by enzymes such as lipoxygenases or cyclooxygenases, but also stereorandomly by autoxidation.
Nadja Kampschulte, Rebecca Kirchhoff, Ariane Löwen, Nils Helge Schebb   +3 more
doaj   +1 more source