Protectin DX Attenuates Lumbar Radicular Pain of Non-compressive Disc Herniation by Autophagy Flux Stimulation via Adenosine Monophosphate-Activated Protein Kinase Signaling [PDF]
Frontiers in Physiology, 2022 Background: Neuroinflammation plays a crucial role in initiating and sustaining lumbar radicular pain (LRP). Protectin DX (PDX) has been experimentally verified to possess pro-resolving properties and anti-inflammatory effects.
Xue Song, Yi-Hao Wang
exaly +4 more sources
Insights in diabetes: Molecular mechanisms-Protectin DX, an anti-inflammatory and a stimulator of inflammation resolution metabolite of docosahexaenoic acid, protects against the development of streptozotocin-induced type 1 and type 2 diabetes mellitus in male Swiss albino mice [PDF]
Frontiers in Endocrinology, 2023 Our previous studies revealed that certain endogenous low molecular weight lipids have potent anti-diabetic actions. Of all, arachidonic acid (AA) and its anti-inflammatory and inflammation resolving metabolite lipoxin A4 (LXA4) are the most potent anti ...
Poorani Rengachar +6 more
doaj +2 more sources
Protectin DX restores Treg/Th17 cell balance in rheumatoid arthritis by inhibiting NLRP3 inflammasome via miR-20a [PDF]
Cell Death and Disease, 2021 Regulatory T-cell (Treg)/T-helper 17 (Th17) cell balance plays an important role in the progression of rheumatoid arthritis (RA). Our study explored the protective effect of protectin DX (PDX), which restored Treg/Th17 cell balance in RA, and the role of
Shengwei Jin +13 more
doaj +2 more sources
Protectin DX increases alveolar fluid clearance in rats with lipopolysaccharide-induced acute lung injury [PDF]
Experimental and Molecular Medicine, 2018 Acute respiratory distress syndrome is a life-threatening critical syndrome resulting largely from the accumulation of and the inability to clear pulmonary edema.
Xiao-Jun Zhuo +9 more
doaj +2 more sources
Protectin DX promotes epithelial injury repair and inhibits fibroproliferation partly via ALX/PI3K signalling pathway. [PDF]
J Cell Mol Med, 2020 Abstract Acute respiratory distress syndrome/acute lung injury (ARDS/ALI) is histologically characterized by extensive alveolar barrier disruption and excessive fibroproliferation responses. Protectin DX (PDX) displays anti‐inflammatory and potent inflammation pro‐resolving actions.
Yang JX +8 more
europepmc +2 more sources
Protectin DX Exhibits Protective Effects in Mouse Model of Lipopolysaccharide-Induced Acute Lung Injury [PDF]
Chinese Medical Journal, 2018 Background: Acute lung injury (ALI) is a severe disease with high mortality and poor prognosis. Protectin DX (PDX), a pro-resolving lipid mediator, exhibits protective effects in ALI.
Wen Tan +6 more
doaj +2 more sources
A New Synthetic Analogue of Protectin DX With Enhanced Therapeutic Potential Against Metabolic-Associated Steatotic Liver Disease. [PDF]
FASEB JThe pro‐resolving lipid mediator PDX, and a novel synthetic analogue AN‐48, were orally administered (50 ng/g) daily to hamsters fed an obesity‐inducing diet. AN‐48 prevented hepatic triglyceride accretion and reduced the expression of fatty acid synthase (FASN), responsible for de novo lipogenesis.
Desmarais F +9 more
europepmc +2 more sources
Protectin DX increases survival in a mouse model of sepsis by ameliorating inflammation and modulating macrophage phenotype [PDF]
Scientific Reports, 2017 Recently, a serial of studies have demonstrated that lipid mediators derived from Omega-3 fatty acid docosahexaenoic acid have pro-resolving or anti-inflammatory effects in many inflammatory diseases. Here, we sought to evaluate whether Protectin DX (PDX,
Haifa Xia +12 more
doaj +2 more sources
Protectin DX resolves fracture-induced postoperative pain in mice via neuronal signaling and GPR37-activated macrophage efferocytosis [PDF]
The Journal of Clinical InvestigationProtectin DX (PDX) is a member of the superfamily of specialized proresolving mediators and exerts anti-inflammatory actions in animal models; however, its signaling mechanism remains unclear.
Yize Li +7 more
doaj +2 more sources
Protectin DX ameliorates palmitate- or high-fat diet-induced insulin resistance and inflammation through an AMPK-PPARα-dependent pathway in mice [PDF]
Scientific Reports, 2017 Protectin DX (PDX), a double lipoxygenase derivative of docosahexaenoic acid, has been reported to attenuate inflammation and insulin resistance. In the current study, we explored the effects of PDX on hyperlipidemia-induced insulin resistance and ...
Tae Woo Jung +3 more
doaj +2 more sources