Results 41 to 50 of about 393 (118)
Molecules, 2020 Nonalcoholic fatty liver disease (NAFLD) is becoming a major public health problem worldwide. The study aimed to evaluate the concentration of eicosanoids in serum and liver tissue during steatosis progression and to assess whether eicosanoid change ...
Dominika Maciejewska +7 more
doaj +1 more source
Journal of Clinical and Translational Science, 2018 OBJECTIVES/SPECIFIC AIMS: Specialized pro-resolving lipid mediators (SPM) actively counter proinflammatory cascades. A deficit of SPMs is one possible mechanism through which inflammation leads to the development of atherosclerotic disease.
Joel Ramirez +5 more
doaj +1 more source
The Activity of Protectin DX, 17 HDHA and Leukotriene B4 Is Correlated with Interleukin-1β (IL-1β) and Interleukin-1 Receptor Antagonist (IL-1Ra) in the Early Subacute Phase of Stroke. [PDF]
Int J Mol SciIschemic stroke is a leading cause of mortality and disability in adults. The inflammatory cascade is driven by various inflammatory molecules, such as interleukin-1β (IL-1β), and counteracted by its antagonist, interleukin-1 receptor antagonist (IL-1Ra). Eicosanoids are inflammatory derivatives of free fatty acids.
Kotlega D +5 more
europepmc +3 more sources
PDX regulates inflammatory cell infiltration via resident macrophage in LPS‐induced lung injury
Journal of Cellular and Molecular Medicine, Volume 24, Issue 18, Page 10604-10614, September 2020., 2020 Abstract Inflammatory cell infiltration contributes to the pathogenesis of acute respiratory distress syndrome (ARDS). Protectin DX (PDX), an endogenous lipid mediator, shows anti‐inflammatory and proresolution bioactions. In vivo, the mice were intraperitoneally injected with PDX (0.1 µg/mouse) after intratracheal (1 mg/kg) or intraperitoneal (10 mg ...
Yang Ye +9 more
wiley +1 more source
The FASEB Journal, Volume 34, Issue 8, Page 10640-10656, August 2020., 2020 Abstract Eicosapentaenoic acid (EPA) has garnered attention after the success of the REDUCE‐IT trial, which contradicted previous conclusions on EPA for cardiovascular disease risk. Here we first investigated EPA's preventative role on hyperglycemia and hyperinsulinemia.
Anandita Pal +14 more
wiley +1 more source
World Journal of Microbiology and Biotechnology, 2023 Abstract Protectins, 10,17-dihydroxydocosahexaenoic acids (10,17-DiHDHAs), are belonged to specialized pro-resolving mediators (SPMs). Protectins are generated by polymorphonuclear leukocytes in humans and resolve inflammation and infection in trace amounts.
Tae-Eui Lee +3 more
openaire +2 more sources
BioMed Research International, Volume 2020, Issue 1, 2020., 2020 Purpose. Osteoarthritis (OA) is one of the common degenerative diseases of the joint in the world. This study was designed to explore the effect of platelet‐rich plasma (PRP) combined with alendronate (ALN) on OA. Methods. We induced OA model by anterior cruciate ligament transection (ACLT) method in rats and treating chondrocytes by IL‐1β in vitro ...
Feng Xin +4 more
wiley +1 more source
Journal of Lipid Research, 2013 We have recently described a di-hydroxylated compound called protectin DX (PDX) which derives from docosahexaenoic acid (DHA) by double lipoxygenation.
Miao Liu +6 more
doaj +1 more source
Correction to "Protectin DX Promotes Epithelial Injury Repair and Inhibits Fibroproliferation Partly via ALX/PI3K Signalling Pathway". [PDF]
J Cell Mol Medeuropepmc +3 more sources
Protectin DX attenuates LPS-induced inflammation and insulin resistance in adipocytes via AMPK-mediated suppression of the NF-κB pathway [PDF]
American Journal of Physiology-Endocrinology and Metabolism, 2018 Several studies have demonstrated that protectins, ω-3 fatty acid-derived proresolution mediators, may ameliorate inflammation. Recently, protectin DX (PDX) was also reported to attenuate inflammation and insulin resistance in several cell types. However, the effects of PDX on inflammation in adipocytes remain ambiguous.
Abd El-Aty, A. M. +4 more
openaire +3 more sources