Results 41 to 50 of about 404 (118)

Plexin C1 modulates metabolic programming for resolution of severe inflammation [PDF]

Cell Communication and Signaling
Persistent, unresolved inflammatory processes disrupt the complex homeostatic state and lead to severe disease, ultimately resulting in organ failure, shock, and death.
Andreas Körner, Michael Koeppen, Jasvir Kaur, Julia C. Fitzgerald, Sarantos Kostidis, Torsten Kaussen, Christoph Trautwein, Martin Giera, Tamam Bakchoul, Alice Bernard, Valbona Mirakaj   +10 more
doaj   +2 more sources

Comparative effects of the ω3 polyunsaturated fatty acid derivatives resolvins E1 and D1 and protectin DX in models of inflammation and pain

Journal of Inflammation Research, 2017
Flávia CS Fonseca,1 Ricardo M Orlando,2 Regina MM Turchetti-Maia,1 Janetti Nogueira de Francischi1 1Department of Pharmacology, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; 2Department of
Fonseca FCS, Orlando RM, Turchetti-Maia RMM, Francischi JN   +3 more
doaj   +1 more source

Metabololipidomic and proteomic profiling reveals aberrant macrophage activation and interrelated immunomodulatory mediator release during aging

Aging Cell, Volume 22, Issue 7, July 2023., 2023
Aging impacts macrophage polarization towards pro‐inflammatory (M1) or pro‐resolving phenotypes (M2a). We show that the metabololipidome of peritoneal macrophages prior and after ex vivo polarization is limited by age, affecting initiation and resolution of inflammation.
Patrick Schädel, Anna Czapka, Nadja Gebert, Ilse Denise Jacobsen, Alessandro Ori, Oliver Werz   +5 more
wiley   +1 more source

Enriched PUFA environment of Leishmania infantum promastigotes promotes the accumulation of lipid mediators and favors parasite infectivity towards J774 murine macrophages

Lipids, Volume 58, Issue 2, Page 81-92, March 2023., 2023
Abstract Leishmania parasites are the causative agents of visceral or cutaneous leishmaniasis in humans and of canine leishmaniosis. The macrophage is the predilected host cell of Leishmania in which the promastigote stage is transformed into amastigote.
Marine Leroux, Hana Bouazizi‐Ben Messaoud, Céline Luquain‐Costaz, Lars P. Jordheim, Pauline Le Faouder, Marie‐Paule Gustin, Karim Aoun, Philippe Lawton, Samira Azzouz‐Maache, Isabelle Delton   +9 more
wiley   +1 more source

Gallic acid regulates immune response in a mouse model of rheumatoid arthritis

Immunity, Inflammation and Disease, Volume 11, Issue 2, February 2023., 2023
1. Treatment of GA (40 and 80 mg/kg/d) reduced clinical arthritis scores and hind paw volume in the CIA mouse model. 2. GA attenuates symptoms in the CIA mouse model by anti‐inflammation and regulating Th17/Treg cell imbalance. Abstract Introduction Previous studies revealed that gallic acid (GA) exerts anti‐inflammation and immuno‐regulatory ...
Siqin Liu, Jiajia Li, Le‐heng Feng
wiley   +1 more source

Mobilisation of HLA‐F on the surface of bronchial epithelial cells and platelets in asthmatic patients

HLA, Volume 100, Issue 5, Page 491-499, November 2022., 2022
Uncontrolled inflammation of the airways in chronic obstructive lung diseases leads to exacerbation, accelerated lung dysfunction and respiratory insufficiency. Among these diseases, asthma affects 358 million people worldwide. Human bronchial epithelium cells (HBEC) express both anti‐inflammatory and activating molecules, and their deregulated ...
Sabrina Fiouane, Mohamad Chebbo, Sophie Beley, Julien Paganini, Christophe Picard, Xavier‐Benoît D'Journo, Pascal‐Alexandre Thomas, Jacques Chiaroni, Pascal Chanez, Delphine Gras, Julie Di Cristofaro   +10 more
wiley   +1 more source

Correction to "Protectin DX Promotes Epithelial Injury Repair and Inhibits Fibroproliferation Partly via ALX/PI3K Signalling Pathway". [PDF]

J Cell Mol Med
europepmc   +3 more sources

Specialized pro‐resolving mediators: biosynthesis and biological role in bacterial infections

The FEBS Journal, Volume 289, Issue 14, Page 4212-4227, July 2022., 2022
Here, we focus on specialized pro‐resolving mediators (SPMs) generated from omega‐3 polyunsaturated fatty acids in response to bacterial infections. SPMs are immunoresolvents that actively terminate inflammation by limiting neutrophil influx, stimulating phagocytosis, bacterial killing and efferocytosis by macrophages.
Paul M. Jordan, Oliver Werz
wiley   +1 more source

Encapsulation of Docosahexaenoic Acid Oil Substantially Improves the Oxylipin Profile of Rat Tissues

Frontiers in Nutrition, 2022
Docosahexaenoic acid (DHA) is a major n-3 polyunsaturated fatty acid (PUFA) particularly involved in cognitive and cardiovascular functions. Due to the high unsaturation index, its dietary intake form has been considered to improve oxidation status and ...
Jun Wang, Jun Wang, Jordane Ossemond, Jordane Ossemond, Yann Le Gouar, Yann Le Gouar, Françoise Boissel, Françoise Boissel, Didier Dupont, Didier Dupont, Frédérique Pédrono, Frédérique Pédrono   +11 more
doaj   +1 more source

The pathogenic mechanism of oral bacteria and treatment with inhibitors

Clinical and Experimental Dental Research, Volume 8, Issue 1, Page 439-448, February 2022., 2022
Abstract Objectives The objective of this study was to introduce the evidence obtained through extensive research that periodontitis increases risk of many systemic diseases. Method Analysis of some oral bacteria (P. gingivalis, T. denticola, T. forsythia, A. actinomycetemcomitans, and F.
Thuraya Elgreu, Sean Lee, Sabrina Wen, Radwa Elghadafi, Thanarut Tangkham, Yun Ma, Bing Liu, Serge Dibart, Xiaoren Tang   +8 more
wiley   +1 more source