Results 31 to 40 of about 404 (118)

Protectin DX Relieve Hyperoxia‐induced Lung Injury by Protecting Pulmonary Endothelial Glycocalyx

Journal of Inflammation Research, 2023
Zhongjie Liang,1,2 Huilin Yue,1 Congcong Xu,1 Qian Wang,3 Shengwei Jin2,3 1Department of Neonatology, The Second Affiliated Hospital, Yuying Children’s Hospital of Wenzhou Medical University, Zhejiang, People’s Republic of China; 2Department of ...
Liang Z, Yue H, Xu C, Wang Q, Jin S
doaj   +1 more source

Herring roe PLs promote SPM biosynthesis in macrophages and a keratinocyte/fibroblast coculture as a model of psoriasis [PDF]

Journal of Lipid Research
Psoriasis is a chronic immune-mediated inflammatory disease affecting the skin, presenting with both local and systemic inflammation as part of its pathophysiology.
Thomas A. Ringheim-Bakka, Amitis Saliani, Tone-Kari K. Østbye, Jennifer Mildenberger, Matthew Dooley, Maftuna Busygina, Mona E. Pedersen, Nina T. Solberg, Jesmond Dalli, Runhild Gammelsaeter   +9 more
doaj   +2 more sources

Efficient One-Step Production of 7S,17S- and 10S,17S-Dihydroxydocosahexaenoic Acids by a Double-Oxygenating 15S-Lipoxygenase From Chlamydomonas incerta. [PDF]

Biotechnol Bioeng
Biotransformation pathway from polyunsaturated fatty acids into dihydroxy fatty acids as lipid mediators by Escherichia coli expressing Chlamydomonas incerta 15S‐lipoxygenase with double oxygenating activity. The 15S‐lipoxygenase was the most efficient for the simultaneous production of resolvin D5 (7S,17S‐dihydroxydocosahexaenoic acid, 7S,17S‐DiHDHA ...
Park HA, Lee J, Oh DK.
europepmc   +2 more sources

Protectin DX, a double lipoxygenase product of DHA, inhibits both ROS production in human neutrophils and cyclooxygenase activities.

Lipids, 2014
AbstractNeutrophils play a major role in inflammation by releasing large amounts of reactive oxygen species (ROS) produced by NADPH oxidase (NOX) and myeloperoxidase (MPO). This ROS overproduction is mediated by phosphorylation of the NOX subunits in an uncontrolled manner.
Liu M, Boussetta T, Makni-Maalej K, Fay M, Driss F, El-Benna J, Lagarde M, Guichardant M.   +7 more
europepmc   +5 more sources

Integrated hydrogel system targeting AMPK/PPARγ signaling in osteoarthritis immunometabolic regulation [PDF]

Journal of Nanobiotechnology
This study introduces CA@PDX HMs, an injectable sustained-release hydrogel system for osteoarthritis (OA) therapy designed to regulate the immunometabolic microenvironment via the AMPK/PPARγ signaling pathway.
Lifeng Ding, Xiufei Teng, Wei Du, Yonghao Zhang, Baozhe Liu, Shang Piao   +5 more
doaj   +2 more sources

Exploring the Relationship Between Diaphragmatic Ultrasound Parameters and Lipid Mediators in Chronic Obstructive Pulmonary Disease: A Case Control Study [PDF]

American Journal of Men's Health
Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory disorder characterized by irreversible airflow limitation and respiratory muscle dysfunction.
Warda Jelassi, Abir Hedhli, Sameh Hajtaeib, Khadija Euchi, Mohamed Kacem Ben Fraj, Sana Cheikhrouhou, Yacine Ouahchi, Meriem Mjid, Sonia Toujani, Moncef Feki, Besma Dhahri   +10 more
doaj   +2 more sources

DHA-Derived Lipid Mediators Attenuate Osteoarthritis by Resolving Inflammation and Protecting Cartilage in Association with the SIRT1 Signaling Pathway [PDF]

Marine Drugs
Osteoarthritis (OA) is a chronic degenerative joint disease characterized by persistent low-grade inflammation and progressive cartilage destruction.
Yan Su, Soon Kyu Kwon, Hack Sun Choi, Yunjon Han, Jung-Hee Park, Jong Hyun Choi, Jeong-Woo Seo   +6 more
doaj   +2 more sources

10-epi-Protectin DX and Resolvin D5_{n-3 DPA} Attenuate Multi-Organ Inflammatory Injury in an LPS-Induced Murine Endotoxemia Model. [PDF]

Int J Mol Sci
Sepsis is a life-threatening syndrome driven by dysregulated immune activation and multi-organ dysfunction, with limited effective therapies. Oxylipins are endogenous lipid mediators that promote the resolution of inflammation and tissue repair, yet their therapeutic potential in systemic inflammatory diseases remains incompletely understood.
Kim S, Kim U, Kim N, Lee TE, Lee J, Oh DK, Shin HY.   +6 more
europepmc   +2 more sources

The Activity of Protectin DX, 17 HDHA and Leukotriene B4 Is Correlated with Interleukin-1β (IL-1β) and Interleukin-1 Receptor Antagonist (IL-1Ra) in the Early Subacute Phase of Stroke. [PDF]

Int J Mol Sci
Ischemic stroke is a leading cause of mortality and disability in adults. The inflammatory cascade is driven by various inflammatory molecules, such as interleukin-1β (IL-1β), and counteracted by its antagonist, interleukin-1 receptor antagonist (IL-1Ra). Eicosanoids are inflammatory derivatives of free fatty acids.
Kotlega D, Drozd A, Zembron-Lacny A, Morawin B, Ryterska K, Szczuko M.   +5 more
europepmc   +3 more sources

Protectin DX attenuates IL-1β-induced inflammation via the AMPK/NF-κB pathway in chondrocytes and ameliorates osteoarthritis progression in a rat model

International Immunopharmacology, 2020
Protectin DX (PDX) has been reported to have extensive anti-inflammatory effects. However, it is unknown whether PDX acts as an anti-inflammatory agent in the context of osteoarthritis (OA). This study aimed to evaluate the anti-inflammatory activity of PDX in vitro and in vivo in a model of OA.
Lunhao Bai, Xinyuan Feng, Yingliang Wei   +2 more
exaly   +3 more sources