Results 31 to 40 of about 393 (118)
Encapsulation of Docosahexaenoic Acid Oil Substantially Improves the Oxylipin Profile of Rat Tissues
Frontiers in Nutrition, 2022 Docosahexaenoic acid (DHA) is a major n-3 polyunsaturated fatty acid (PUFA) particularly involved in cognitive and cardiovascular functions. Due to the high unsaturation index, its dietary intake form has been considered to improve oxidation status and ...
Jun Wang +11 more
doaj +1 more source
Specialized pro‐resolving mediators: biosynthesis and biological role in bacterial infections
The FEBS Journal, Volume 289, Issue 14, Page 4212-4227, July 2022., 2022 Here, we focus on specialized pro‐resolving mediators (SPMs) generated from omega‐3 polyunsaturated fatty acids in response to bacterial infections. SPMs are immunoresolvents that actively terminate inflammation by limiting neutrophil influx, stimulating phagocytosis, bacterial killing and efferocytosis by macrophages.
Paul M. Jordan, Oliver Werz
wiley +1 more source
The pathogenic mechanism of oral bacteria and treatment with inhibitors
Clinical and Experimental Dental Research, Volume 8, Issue 1, Page 439-448, February 2022., 2022 Abstract Objectives The objective of this study was to introduce the evidence obtained through extensive research that periodontitis increases risk of many systemic diseases. Method Analysis of some oral bacteria (P. gingivalis, T. denticola, T. forsythia, A. actinomycetemcomitans, and F.
Thuraya Elgreu +8 more
wiley +1 more source
Maternal prebiotic supplementation impacts colitis development in offspring mice
Frontiers in Nutrition, 2023 Background and aimsMaternal diet plays a key role in preventing or contributing to the development of chronic diseases, such as obesity, allergy, and brain disorders.
Amélie Lê +12 more
doaj +1 more source
Lipids, 2014 AbstractNeutrophils play a major role in inflammation by releasing large amounts of reactive oxygen species (ROS) produced by NADPH oxidase (NOX) and myeloperoxidase (MPO). This ROS overproduction is mediated by phosphorylation of the NOX subunits in an uncontrolled manner.
Liu M +7 more
europepmc +5 more sources
Omega‐6 and omega‐3 oxylipins as potential markers of cardiometabolic risk in young adults
Obesity, Volume 30, Issue 1, Page 50-61, January 2022., 2022 Abstract Objective Omega‐6 and omega‐3 oxylipins are known to play a role in inflammation and cardiometabolic diseases in preclinical models. The associations between plasma levels of omega‐6 and omega‐3 polyunsaturated fatty acid–derived oxylipins and body composition and cardiometabolic risk factors in young adults were assessed.
Lucas Jurado‐Fasoli +12 more
wiley +1 more source
Aging Cell, Volume 20, Issue 6, June 2021., 2021 Chronic low‐grade inflammation of aging muscle was associated with a basal deficiency of maresin 1, resolvin E3, 8‐oxo‐resolvin D1, and anti‐inflammatory fatty acid epoxides. Aged mice produced normal amounts of most prostaglandins following muscle injury but were deficient in local biosynthesis of markers of the lipoxins, E‐resolvins, D‐resolvins, and
James F. Markworth +9 more
wiley +1 more source
10-epi-Protectin DX and Resolvin D5<sub>n-3 DPA</sub> Attenuate Multi-Organ Inflammatory Injury in an LPS-Induced Murine Endotoxemia Model. [PDF]
Int J Mol SciSepsis is a life-threatening syndrome driven by dysregulated immune activation and multi-organ dysfunction, with limited effective therapies. Oxylipins are endogenous lipid mediators that promote the resolution of inflammation and tissue repair, yet their therapeutic potential in systemic inflammatory diseases remains incompletely understood.
Kim S +6 more
europepmc +2 more sources
Protectin DX Ameliorates Hepatic Steatosis by Suppression of Endoplasmic Reticulum Stress via AMPK-Induced ORP150 Expression [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2018 Docosahexaenoic acid (DHA) and its bioactive compounds may have suppressive effects on inflammation, endoplasmic reticulum (ER) stress, and insulin resistance. Protectin DX (PDX), a double lipoxygenase product from DHA has shown a suppressive effect on inflammation and insulin resistance.
Kyung, Eun Jung +8 more
openaire +3 more sources
A role for 12/15-lipoxygenase-derived proresolving mediators in postoperative ileus: protectin DX-regulated neutrophil extravasation [PDF]
Journal of Leukocyte Biology, 2015 Abstract Resolution of inflammation is an active counter-regulatory mechanism involving polyunsaturated fatty acid-derived proresolving lipid mediators. Postoperative intestinal motility disturbances, clinically known as postoperative ileus, occur frequently after abdominal surgery and are mediated by a complex inflammation of the ...
Kathy, Stein +7 more
openaire +2 more sources