Results 51 to 60 of about 404 (118)
Omega‐6 and omega‐3 oxylipins as potential markers of cardiometabolic risk in young adults
Obesity, Volume 30, Issue 1, Page 50-61, January 2022., 2022 Abstract Objective Omega‐6 and omega‐3 oxylipins are known to play a role in inflammation and cardiometabolic diseases in preclinical models. The associations between plasma levels of omega‐6 and omega‐3 polyunsaturated fatty acid–derived oxylipins and body composition and cardiometabolic risk factors in young adults were assessed.
Lucas Jurado‐Fasoli +12 more
wiley +1 more source
Maternal prebiotic supplementation impacts colitis development in offspring mice
Frontiers in Nutrition, 2023 Background and aimsMaternal diet plays a key role in preventing or contributing to the development of chronic diseases, such as obesity, allergy, and brain disorders.
Amélie Lê +12 more
doaj +1 more source
Aging Cell, Volume 20, Issue 6, June 2021., 2021 Chronic low‐grade inflammation of aging muscle was associated with a basal deficiency of maresin 1, resolvin E3, 8‐oxo‐resolvin D1, and anti‐inflammatory fatty acid epoxides. Aged mice produced normal amounts of most prostaglandins following muscle injury but were deficient in local biosynthesis of markers of the lipoxins, E‐resolvins, D‐resolvins, and
James F. Markworth +9 more
wiley +1 more source
Protectin DX Ameliorates Hepatic Steatosis by Suppression of Endoplasmic Reticulum Stress via AMPK-Induced ORP150 Expression [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2018 Docosahexaenoic acid (DHA) and its bioactive compounds may have suppressive effects on inflammation, endoplasmic reticulum (ER) stress, and insulin resistance. Protectin DX (PDX), a double lipoxygenase product from DHA has shown a suppressive effect on inflammation and insulin resistance.
Kyung, Eun Jung +8 more
openaire +3 more sources
A role for 12/15-lipoxygenase-derived proresolving mediators in postoperative ileus: protectin DX-regulated neutrophil extravasation [PDF]
Journal of Leukocyte Biology, 2015 Abstract Resolution of inflammation is an active counter-regulatory mechanism involving polyunsaturated fatty acid-derived proresolving lipid mediators. Postoperative intestinal motility disturbances, clinically known as postoperative ileus, occur frequently after abdominal surgery and are mediated by a complex inflammation of the ...
Kathy, Stein +7 more
openaire +2 more sources
Molecules, 2020 Nonalcoholic fatty liver disease (NAFLD) is becoming a major public health problem worldwide. The study aimed to evaluate the concentration of eicosanoids in serum and liver tissue during steatosis progression and to assess whether eicosanoid change ...
Dominika Maciejewska +7 more
doaj +1 more source
Journal of Clinical and Translational Science, 2018 OBJECTIVES/SPECIFIC AIMS: Specialized pro-resolving lipid mediators (SPM) actively counter proinflammatory cascades. A deficit of SPMs is one possible mechanism through which inflammation leads to the development of atherosclerotic disease.
Joel Ramirez +5 more
doaj +1 more source
PDX regulates inflammatory cell infiltration via resident macrophage in LPS‐induced lung injury
Journal of Cellular and Molecular Medicine, Volume 24, Issue 18, Page 10604-10614, September 2020., 2020 Abstract Inflammatory cell infiltration contributes to the pathogenesis of acute respiratory distress syndrome (ARDS). Protectin DX (PDX), an endogenous lipid mediator, shows anti‐inflammatory and proresolution bioactions. In vivo, the mice were intraperitoneally injected with PDX (0.1 µg/mouse) after intratracheal (1 mg/kg) or intraperitoneal (10 mg ...
Yang Ye +9 more
wiley +1 more source
The FASEB Journal, Volume 34, Issue 8, Page 10640-10656, August 2020., 2020 Abstract Eicosapentaenoic acid (EPA) has garnered attention after the success of the REDUCE‐IT trial, which contradicted previous conclusions on EPA for cardiovascular disease risk. Here we first investigated EPA's preventative role on hyperglycemia and hyperinsulinemia.
Anandita Pal +14 more
wiley +1 more source
World Journal of Microbiology and Biotechnology, 2023 Abstract Protectins, 10,17-dihydroxydocosahexaenoic acids (10,17-DiHDHAs), are belonged to specialized pro-resolving mediators (SPMs). Protectins are generated by polymorphonuclear leukocytes in humans and resolve inflammation and infection in trace amounts.
Tae-Eui Lee +3 more
openaire +2 more sources