Results 21 to 30 of about 393 (118)
Journal of Inflammation Research, 2017 Flávia CS Fonseca,1 Ricardo M Orlando,2 Regina MM Turchetti-Maia,1 Janetti Nogueira de Francischi1 1Department of Pharmacology, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; 2Department of
Fonseca FCS +3 more
doaj +1 more source
Posttreatment with Protectin DX ameliorates bleomycin-induced pulmonary fibrosis and lung dysfunction in mice. [PDF]
Sci Rep, 2017 AbstractProtectin DX (10S,17S-dihydroxydocosa-4Z,7Z,11E,13Z,15E,19Z-hexaenoic acid) (PDX), generated from Ω-3 fatty docosahexaenoic acids, is believed to exert anti-inflammatory and proresolution bioactions. To date, few studies have been performed regarding its effect on pulmonary fibrosis. Herein we show that PDX exerts a potential therapeutic effect
Li H +9 more
europepmc +4 more sources
Protectin DX alleviates insulin resistance by activating a myokine-liver glucoregulatory axis. [PDF]
Nat Med, 2014 We previously demonstrated that low biosynthesis of ω-3 fatty acid-derived proresolution mediators, termed protectins, is associated with an impaired global resolution capacity, inflammation and insulin resistance in obese high-fat diet-fed mice. These findings prompted a more direct study of the therapeutic potential of protectins for the treatment of
White PJ +6 more
europepmc +4 more sources
Protectin DX promotes the inflammatory resolution via activating COX-2/L-PGDS-PGD2 and DP1 receptor in acute respiratory distress syndrome. [PDF]
Int Immunopharmacol, 2022 Acute respiratory distress syndrome (ARDS) is characterized by uncontrollable inflammation. Cyclooxygenase-2(COX-2) and its metabolite prostaglandins are known to promote the inflammatory resolution of ARDS. Recently, a newly discovered endogenous lipid mediator, Protectin DX (PDX), was also shown to mediate the resolution of inflammation. However, the
Hu X +10 more
europepmc +3 more sources
In Vitro Biosynthetic Pathway Investigations of Neuroprotectin D1 (NPD1) and Protectin DX (PDX) by Human 12-Lipoxygenase, 15-Lipoxygenase-1, and 15-Lipoxygenase-2. [PDF]
Biochemistry, 2021 In this paper, human platelet 12-lipoxygenase [h12-LOX (ALOX12)], human reticulocyte 15-lipoxygenase-1 [h15-LOX-1 (ALOX15)], and human epithelial 15-lipoxygenase-2 [h15-LOX-2 (ALOX15B)] were observed to react with docosahexaenoic acid (DHA) and produce 17S-hydroperoxy-4Z,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid (17S-HpDHA).
Tsai WC +5 more
europepmc +5 more sources
Comparative effects of the ω3 polyunsaturated fatty acid derivatives resolvins E1 and D1 and protectin DX in models of inflammation and pain. [PDF]
J Inflamm Res, 2017 Specialized pro-resolving lipid mediators (SPMs), also known as lipoxins, resolvins (Rvs), protectins and maresins, have been implicated in the resolution of the inflammatory process. However, a systematic comparison of their activity in the relief of inflammation and pain models is still lacking.The effects of Rvs E1 and D1 and protectin DX (PDX) were
Fonseca FC +3 more
europepmc +5 more sources
Aging Cell, Volume 22, Issue 7, July 2023., 2023 Aging impacts macrophage polarization towards pro‐inflammatory (M1) or pro‐resolving phenotypes (M2a). We show that the metabololipidome of peritoneal macrophages prior and after ex vivo polarization is limited by age, affecting initiation and resolution of inflammation.
Patrick Schädel +5 more
wiley +1 more source
Lipids, Volume 58, Issue 2, Page 81-92, March 2023., 2023 Abstract Leishmania parasites are the causative agents of visceral or cutaneous leishmaniasis in humans and of canine leishmaniosis. The macrophage is the predilected host cell of Leishmania in which the promastigote stage is transformed into amastigote.
Marine Leroux +9 more
wiley +1 more source
Gallic acid regulates immune response in a mouse model of rheumatoid arthritis
Immunity, Inflammation and Disease, Volume 11, Issue 2, February 2023., 2023 1. Treatment of GA (40 and 80 mg/kg/d) reduced clinical arthritis scores and hind paw volume in the CIA mouse model. 2. GA attenuates symptoms in the CIA mouse model by anti‐inflammation and regulating Th17/Treg cell imbalance. Abstract Introduction Previous studies revealed that gallic acid (GA) exerts anti‐inflammation and immuno‐regulatory ...
Siqin Liu, Jiajia Li, Le‐heng Feng
wiley +1 more source
HLA, Volume 100, Issue 5, Page 491-499, November 2022., 2022 Uncontrolled inflammation of the airways in chronic obstructive lung diseases leads to exacerbation, accelerated lung dysfunction and respiratory insufficiency. Among these diseases, asthma affects 358 million people worldwide. Human bronchial epithelium cells (HBEC) express both anti‐inflammatory and activating molecules, and their deregulated ...
Sabrina Fiouane +10 more
wiley +1 more source