The Activity of Protectin DX, 17 HDHA and Leukotriene B4 Is Correlated with Interleukin-1β (IL-1β) and Interleukin-1 Receptor Antagonist (IL-1Ra) in the Early Subacute Phase of Stroke. [PDF]
Int J Mol SciIschemic stroke is a leading cause of mortality and disability in adults. The inflammatory cascade is driven by various inflammatory molecules, such as interleukin-1β (IL-1β), and counteracted by its antagonist, interleukin-1 receptor ...
Kotlega D +5 more
europepmc +2 more sources
Herring roe PLs promote SPM biosynthesis in macrophages and a keratinocyte/fibroblast coculture as a model of psoriasis [PDF]
Journal of Lipid ResearchPsoriasis is a chronic immune-mediated inflammatory disease affecting the skin, presenting with both local and systemic inflammation as part of its pathophysiology.
Thomas A. Ringheim-Bakka +9 more
doaj +2 more sources
Protectin DX resolves fracture-induced postoperative pain in mice via neuronal signaling and GPR37-activated macrophage efferocytosis [PDF]
The Journal of Clinical InvestigationProtectin DX (PDX) is a member of the superfamily of specialized proresolving mediators and exerts anti-inflammatory actions in animal models; however, its signaling mechanism remains unclear.
Yize Li +7 more
doaj +2 more sources
Protectin conjugates in tissue regeneration 1 alleviates sepsis-induced acute lung injury by inhibiting ferroptosis [PDF]
Journal of Translational Medicine, 2023 Background Acute lung injury (ALI) is a common and serious complication of sepsis with high mortality. Ferroptosis, categorized as programmed cell death, contributes to the development of lung injury. Protectin conjugates in tissue regeneration 1 (PCTR1)
Ya Lv +14 more
doaj +2 more sources
Protectin D1 Is Generated in Asthma and Dampens Airway Inflammation and Hyperresponsiveness [PDF]
The Journal of Immunology, 2007 Abstract Protectins are newly identified natural chemical mediators that counter leukocyte activation to promote resolution of inflammation. In this study, we provide the first evidence for protectin D1 (PD1, 10R,17S-dihydroxy-docosa-4Z,7Z,11E,13E,15Z,19Z-hexaenoic acid) formation from docosahexaenoic acid in human asthma in vivo and ...
Levy, Bruce +8 more
openaire +6 more sources
Protectin DX Exhibits Protective Effects in Mouse Model of Lipopolysaccharide-Induced Acute Lung Injury [PDF]
Chinese Medical Journal, 2018 Background: Acute lung injury (ALI) is a severe disease with high mortality and poor prognosis. Protectin DX (PDX), a pro-resolving lipid mediator, exhibits protective effects in ALI.
Wen Tan +6 more
doaj +2 more sources
The potential role of n-3 fatty acids and their lipid mediators on asthmatic airway inflammation [PDF]
Frontiers in ImmunologyAsthma, is a common, significant and diverse condition marked by persistent airway inflammation, with a major impact on human health worldwide. The predisposing factors for asthma are complex and widespread.
Yuan Tian +3 more
doaj +2 more sources
Bioactive lipid mediator class switching regulates myogenic cell progression and muscle regeneration [PDF]
Nature CommunicationsThe muscle stem cell niche is well-described as influencing myogenic cell fate decision; however, the intrinsic mechanisms driving muscle stem cell progression during myogenesis are not yet fully elucidated.
Paul Fabre +11 more
doaj +2 more sources
Protectin DX increases survival in a mouse model of sepsis by ameliorating inflammation and modulating macrophage phenotype [PDF]
Scientific Reports, 2017 Recently, a serial of studies have demonstrated that lipid mediators derived from Omega-3 fatty acid docosahexaenoic acid have pro-resolving or anti-inflammatory effects in many inflammatory diseases. Here, we sought to evaluate whether Protectin DX (PDX,
Haifa Xia +12 more
doaj +2 more sources