Protectin DX increases alveolar fluid clearance in rats with lipopolysaccharide-induced acute lung injury [PDF]
Experimental and Molecular Medicine, 2018 Acute respiratory distress syndrome is a life-threatening critical syndrome resulting largely from the accumulation of and the inability to clear pulmonary edema.
Xiao-Jun Zhuo +9 more
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Insights in diabetes: Molecular mechanisms-Protectin DX, an anti-inflammatory and a stimulator of inflammation resolution metabolite of docosahexaenoic acid, protects against the development of streptozotocin-induced type 1 and type 2 diabetes mellitus in male Swiss albino mice [PDF]
Frontiers in Endocrinology, 2023 Our previous studies revealed that certain endogenous low molecular weight lipids have potent anti-diabetic actions. Of all, arachidonic acid (AA) and its anti-inflammatory and inflammation resolving metabolite lipoxin A4 (LXA4) are the most potent anti ...
Poorani Rengachar +6 more
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Herring roe PLs promote SPM biosynthesis in macrophages and a keratinocyte/fibroblast coculture as a model of psoriasis [PDF]
Journal of Lipid ResearchPsoriasis is a chronic immune-mediated inflammatory disease affecting the skin, presenting with both local and systemic inflammation as part of its pathophysiology.
Thomas A. Ringheim-Bakka +9 more
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Tocotrienol metabolites redirect lipid mediator production in innate immune cells towards inflammation resolution [PDF]
Acta Pharmaceutica Sinica BRestoring homeostasis in persistent inflammation requires suppressing the inflammatory response and promoting resolution. Currently, no clinically used small molecules intentionally achieve both effects. Endogenous long-chain vitamin E metabolites (LCMs)
Stephan Permann +20 more
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Protectin DX resolves fracture-induced postoperative pain in mice via neuronal signaling and GPR37-activated macrophage efferocytosis [PDF]
The Journal of Clinical InvestigationProtectin DX (PDX) is a member of the superfamily of specialized proresolving mediators and exerts anti-inflammatory actions in animal models; however, its signaling mechanism remains unclear.
Yize Li +7 more
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, 1998 Protectin (CD59) is a glycophosphoinsitol (GPI)-anchored defender of human cells against lysis by the membrane attack complex of complement. In this study, we examined whether protectin released from human cell membranes can incorporate into the surface ...
Jarvis, Gary A. +3 more
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Protectin DX alleviates lumbar radicular pain in rats by suppressing RIP3/MLKL-associated necroinflammation through restoration of autophagic function [PDF]
Frontiers in PharmacologyBackgroundLumbar radicular pain (LRP) is a prevalent neuropathic pain disorder driven by nucleus pulposus (NP)-induced inflammation. Protectin DX (PDX), a novel specialized pro-resolving lipid mediator (SPM), exerts pro-resolving and analgesic effects in
Qing-xiang Zhao +3 more
doaj +2 more sources
Bioactive lipid mediator class switching regulates myogenic cell progression and muscle regeneration [PDF]
Nature CommunicationsThe muscle stem cell niche is well-described as influencing myogenic cell fate decision; however, the intrinsic mechanisms driving muscle stem cell progression during myogenesis are not yet fully elucidated.
Paul Fabre +11 more
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Integrated hydrogel system targeting AMPK/PPARγ signaling in osteoarthritis immunometabolic regulation [PDF]
Journal of NanobiotechnologyThis study introduces CA@PDX HMs, an injectable sustained-release hydrogel system for osteoarthritis (OA) therapy designed to regulate the immunometabolic microenvironment via the AMPK/PPARγ signaling pathway.
Lifeng Ding +5 more
doaj +2 more sources
, 1996 Adult periodontitis (AP) is a chronic inflammatory disease of the tooth-supporting apparatus. Activation products of the inflammation-inducing complement system have been detected in the gingival crevicular fluid at the site of gingival inflammation.
Meri, S. +1 more
core +11 more sources