Results 31 to 40 of about 8,778 (174)

Host Lipid Mediators in Leprosy: The Hypothesized Contributions to Pathogenesis

Frontiers in Immunology, 2018
The spectrum of clinical forms observed in leprosy and its pathogenesis are dictated by the host’s immune response against Mycobacterium leprae, the etiological agent of leprosy.
Carlos A. M. Silva, John T. Belisle
doaj   +1 more source

Der Einfluss von Resolvin E1 auf die Proliferation von pulmonal-arteriellen glatten Muskelzellen [PDF]

, 2023
Für die Entwicklung der PH sind verschiedene Ätiologien bekannt. Die chronisch- hypoxische Exposition ist eine bekannte Ursache und führt zu einem pulmonal- vaskulären Remodeling.
Lo, Kevin
core   +1 more source

The Anti-Inflammatory Role of Omega-3 Polyunsaturated Fatty Acids Metabolites in Pre-Clinical Models of Psychiatric, Neurodegenerative, and Neurological Disorders

Frontiers in Psychiatry, 2020
Inflammation has been identified as one of the main pathophysiological mechanisms underlying neuropsychiatric and neurodegenerative disorders. Despite the role of inflammation in those conditions, there is still a lack of effective anti-inflammatory ...
Juliette Giacobbe, Bonnie Benoiton, Patricia Zunszain, Carmine M. Pariante, Alessandra Borsini   +4 more
doaj   +1 more source

Lipoxins and Resolvins in Patients With Pancreatic Cancer: A Preliminary Report

Frontiers in Oncology, 2022
Eicosanoids are bioactive lipids derived from arachidonic acid, which have emerged as key regulators of a wide variety of pathophysiological processes in recent times and are implicated as mediators of gastrointestinal cancer.
Wojciech Blogowski, Katarzyna Dolegowska, Anna Deskur, Barbara Dolegowska, Teresa Starzynska   +4 more
doaj   +1 more source

Resolvin D1 and D2 Reverse Lipopolysaccharide-Induced Depression-Like Behaviors Through the mTORC1 Signaling Pathway [PDF]

, 2017
Background:Resolvin D1 and D2 are bioactive lipid mediators that are generated from docosahexaenoic acid. Although recent preclinical studies suggest that these compounds have antidepressant effects, their mechanisms of action remain unclear.
Kotomi Yoshikawa, Satoh, Masamichi, Satoshi Deyama, Masamichi Satoh, Shimoda, Kento, Soichiro Ide, Ishikawa, Yuka, Kento Shimoda, Masabumi Minami, Yuka Ishikawa, Yoshikawa, Kotomi, Minami, Masabumi, Ide, Soichiro, Deyama, Satoshi   +13 more
core   +1 more source

Role of Resolvin E1 in macrophage polarization as a therapeutic strategy for root resorption: In silico and in vitro analysis

Indian Journal of Dental Research
Objectives: This study aimed to evaluate the interaction of Resolvin E1 with macrophage-associated inflammatory markers and assess its potential role in macrophage polarization relevant to root resorption therapy. Methods: Molecular docking was performed
Nandini Suresh, Alan M. Punnoose
doaj   +1 more source

Total Synthesis and Bioactivity of Resolvin E2

, 2016
Resolvin E2 is a potent anti-inflammatory compound, derived from eicosapentaenoic acid. The efficient total synthesis of resolvin E2 by taking advantage of its intrinsic pseudoenantiomeric substructures is reported. The synthetic resolvin E2 proved to be
Seiji Ogawa (1446016), Yoshiyuki Yokokura (2355289), Hiroyuki Arai (37989), Masayuki Inoue (737292), Daisuke Urabe (1554973), Makoto Arita (82805)   +5 more
core   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

Atividade anti-hiperalgésica das resolvinas no modelo de dor inflamatória articular em ratos [PDF]

, 2011
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2011A descoberta de que a resolução da inflamação é um processo ativo, no qual vários mediadores lipídicos
Garcia, Juliana Fabris Lima
core  

USP4‐Dependent CHAF1B Stabilization Regulates Distinct SETDB1 Ubiquitin States Linked to AKT T308 Signaling and Lipogenic Remodeling in HCC

Advanced Science, EarlyView.
USP4 stabilizes CHAF1B by limiting K48‐linked ubiquitination. Stabilized CHAF1B supports UHRF1‐associated K63‐linked SETDB1 ubiquitination and cytoplasmic redistribution, whereas CHAF1B loss favors VHL‐dependent K11‐associated degradative ubiquitination and proteasomal loss of SETDB1.
Saiyan Bian, Yun Tong, Wenkai Ni, Zhangzhi Tang, Weiting Chen, Kexin Ma, Lihan Jiang, Jiayu Shao, Xuyang He, Wenjie Zheng   +9 more
wiley   +1 more source