Results 31 to 40 of about 6,979 (181)

Resolvins on the way to resolution [PDF]

Journal of Experimental Medicine, 2015
![Figure][1] Insight from Peter Ward Over the past several decades, lipid products have been found to exert both proinflammatory effects (e.g., prostaglandins and leukotrienes) and antiinflammatory activities (e.g., lipoxins and products derived from docosahexaenoic acid ...
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Resolvin D1 and Resolvin D2 Govern Local Inflammatory Tone in Obese Fat [PDF]

The Journal of Immunology, 2012
Abstract The unprecedented increase in the prevalence of obesity and obesity-related disorders is causally linked to a chronic state of low-grade inflammation in adipose tissue. Timely resolution of inflammation and return of this tissue to homeostasis are key to reducing obesity-induced metabolic dysfunctions.
Joan, Clària, Jesmond, Dalli, Stephanie, Yacoubian, Fei, Gao, Charles N, Serhan   +4 more
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Association of resolvin level in pregnant women with preeclampsia and metabolic syndrome

Taiwanese Journal of Obstetrics & Gynecology, 2020
Objective: Preeclampsia (PE) and Metabolic syndrome (MetS) are multifactorial conditions and are major causes of maternal and neonatal morbidity and mortality worldwide. Both conditions are pro-inflammatory and can be causative factor for vascular damage.
Sabah Farhat, Muhammad Usman Zafar, Maheen A. Sheikh, Chaudhry Muhammad Qasim, Faiza Urooj, Syeda Sadia Fatima   +5 more
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Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Potent Immunoresolvents

Chemistry & Biology, 2013
Resolvins are a family of n-3 lipid mediators initially identified in resolving inflammatory exudates that temper inflammatory responses to promote catabasis. Here, temporal metabololipidomics with self-limited resolving exudates revealed that resolvin (Rv) D3 has a distinct time frame from other lipid mediators, appearing late in the resolution phase.
Dalli, Jesmond, Winkler, Jeremy W., Colas, Romain A., Arnardottir, Hildur, Cheng, Chien-Yee C., Chiang, Nan, Petasis, Nicos A., Serhan, Charles N.   +7 more
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Pro-Resolving Ligands Orchestrate Phagocytosis

Frontiers in Immunology, 2021
The resolution of inflammation is a tissue protective program that is governed by several factors including specialized pro-resolving mediators (SPMs), proteins, gasses and nucleotides. Pro-resolving mediators activate counterregulatory programs to quell
Christa Decker, Sudeshna Sadhu, Gabrielle Fredman   +2 more
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Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators—What is the Evidence so far?

Frontiers in Pharmacology, 2022
Formation of specialized pro-resolving lipid mediators (SPMs) such as lipoxins or resolvins usually involves arachidonic acid 5-lipoxygenase (5-LO, ALOX5) and different types of arachidonic acid 12- and 15-lipoxygenating paralogues (15-LO1, ALOX15; 15 ...
Nils Helge Schebb, Hartmut Kühn, Astrid S. Kahnt, Katharina M. Rund, Valerie B. O’Donnell, Nicolas Flamand, Marc Peters-Golden, Per-Johan Jakobsson, Karsten H. Weylandt, Nadine Rohwer, Nadine Rohwer, Robert C. Murphy, Gerd Geisslinger, Gerd Geisslinger, Garret A. FitzGerald, Julien Hanson, Julien Hanson, Claes Dahlgren, Mohamad Wessam Alnouri, Stefan Offermanns, Stefan Offermanns, Dieter Steinhilber, Dieter Steinhilber   +22 more
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Roles of Resolvins in Chronic Inflammatory Response

International Journal of Molecular Sciences, 2022
An inflammatory response is beneficial to the organism, while an excessive uncontrolled inflammatory response can lead to the nonspecific killing of tissue cells. Therefore, promoting the resolution of inflammation is an important mechanism for protecting an organism suffering from chronic inflammatory diseases.
Chang Liu, Dancai Fan, Qian Lei, Aiping Lu, Xiaojuan He   +4 more
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Host Lipid Mediators in Leprosy: The Hypothesized Contributions to Pathogenesis

Frontiers in Immunology, 2018
The spectrum of clinical forms observed in leprosy and its pathogenesis are dictated by the host’s immune response against Mycobacterium leprae, the etiological agent of leprosy.
Carlos A. M. Silva, John T. Belisle
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Protectin and resolvin gut inflammation [PDF]

Science, 2017
Inflammation Even when laced with syrup, cod-liver oil is disgusting, but it is an important source of omega-3-docosapentaenoic fatty acid (DPA). After being swallowed, DPA is converted into specialized proresolving lipid mediators (SPMs), including protectin and resolvin.
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Resolvin D1 and Aspirin-Triggered Resolvin D1 Promote Resolution of Allergic Airways Responses [PDF]

The Journal of Immunology, 2012
Abstract Asthma is a disease of airway inflammation that in most cases fails to resolve. The resolution of inflammation is an active process governed by specific chemical mediators, including D-series resolvins. In this study, we determined the impact of resolvin D1 (RvD1) and aspirin-triggered RvD1 (AT-RvD1) on the development of ...
Alexandre P, Rogerio, Oliver, Haworth, Roxanne, Croze, Sungwhan F, Oh, Mohib, Uddin, Troy, Carlo, Michael A, Pfeffer, Rebekah, Priluck, Charles N, Serhan, Bruce D, Levy   +9 more
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