Results 61 to 70 of about 209 (125)

Differential Effects of Benralizumab and Mepolizumab on Pro‐Resolving Mediators

Allergy, EarlyView.
Jaime Bernaola, José Antonio Cañas, Álvaro Arranz‐Fragua, José Manuel Rodrigo‐Muñoz, Daniel Rodríguez‐González, Antonio Serrano‐Santiago, Gema Guillén‐Sánchez, Alma Martínez Fernández, Marcela Valverde‐Monge, Diana Betancor, Erwin Javier Pinillos‐Robles, Claudia Rodríguez‐Busto, María Jesús Rodríguez‐Nieto, Joaquín Sastre, Victoria del Pozo   +14 more
wiley   +1 more source

Macrophage: Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
Macrophages are sentinel innate immune cells that arise from embryonic precursors and bone marrow monocytes, displaying a functional continuum that transcends the classical M1 (pro‐inflammatory)/M2 (anti‐inflammatory) dichotomy. Under homeostatic conditions, balanced M1/M2 polarization preserves tissue integrity by coordinating immune surveillance ...
Bihang Sun, Linqing Wen, Shiyun Tang, Lu Liu, Nianzhi Chen   +4 more
wiley   +1 more source

Identification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3. [PDF]

PLoS ONE, 2016
Maresin conjugates in tissue regeneration (MCTR) are a new family of evolutionarily conserved chemical signals that orchestrate host responses to promote tissue regeneration and resolution of infections.
Jesmond Dalli, Julia M Sanger, Ana R Rodriguez, Nan Chiang, Bernd W Spur, Charles N Serhan   +5 more
doaj   +1 more source

Engineered probiotics platform for resolvin E1 biosynthesis confers protection against inflammatory disease

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
An engineered EcN‐RvE1 probiotic platform enables sustained biosynthesis of the pro‐resolving mediator RvE1 via inducible COX2/5‐LOX expression. Oral administration achieves long‐term intestinal persistence and systemic anti‐inflammatory effects in murine models of acute inflammation and colitis, offering a promising oral therapeutic strategy for ...
Xiaoxiao Li, Jiejing Lin, Qingqing Liu, Yiqun Wu, Qian Wu, Zewei Zhao, Yi Cai, Shengliang Lin, Zijie Zheng, Xinpan Chen, Jin Li, Zhonghan Yang   +11 more
wiley   +1 more source

Subfatin, Asprosin, Alamandine and Maresin-1 Inflammation Molecules in Cardiopulmonary Bypass

Journal of Inflammation Research, 2023
Onur Hanbeyoglu,1 Suna Aydin2– 4 1Department of Anesthesiology, Fethi Sekin City Hospital, Elazig, Turkiye; 2Department of Cardiovascular Surgery, Fethi Sekin City Hospital, Elazig, Turkiye; 3Department of Anatomy, School of Medicine, Firat University ...
Hanbeyoglu O, Aydin S
doaj  

Inflammaging: Experimental Insights and Translational Advances

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Inflammaging is a chronic, low‐grade, sterile inflammation associated with aging that contributes to age‐related diseases and functional decline. Recent research suggests that targeting inflammaging through senolytics, metabolic modulators, microbiome‐based interventions, and lifestyle modifications may help improve healthspan, reduce chronic disease ...
Andrea Cossarizza
wiley   +1 more source

Maresin-1 and maresin-2 as synovial fluid biomarkers in psoriatic, rheumatoid, and osteoarthritis

Frontiers in Medicine
ObjectiveTo investigate synovial fluid levels of maresin-1 (MaR-1) and maresin-2 (MaR-2) in patients with psoriatic arthritis (PsA), rheumatoid arthritis (RA), osteoarthritis (OA), and controls, and to assess their ability to differentiate PsA from RA ...
Sukru Demir, Bugra Can, Omer Esmez, Mustafa Ata Aydin, Sevval Yagmur Gencer, Furkan Bildirici, Süleyman Serdar Koca, İbrahim Sahin, İbrahim Sahin, Suleyman Aydin   +9 more
doaj   +1 more source

Omega‐3 Long‐Chain Polyunsaturated Fatty Acid Metabolite 16‐Hydroxydocosahexaenoic Acid Strengthens Non‐Small Cell Lung Cancer Radiosensitivity Through Peroxisome Proliferator‐Activated Receptor γ

Food Frontiers, Volume 7, Issue 4, July 2026.
This study revealed a novel mechanism by which ω‐3 LCPUFA metabolism regulated NSCLC cell radiosensitivity. Specific ω‐3 LCPUFA metabolite 16‐HDHA plasma levels were elevated in the radiosensitive NSCLC patients and enhanced the cytotoxic effects of radiation on NSCLC cells.
Mengqin Wang, Jiang Luo, Mini Zhang, Shuling Li, Jiawen Tang, Qingwei Wang, Yuzhu Wu, Ziyu Jiang, Conghua Xie, Yan Gong   +9 more
wiley   +1 more source

Tracking COVID‐19 Severity and Progression Through Amines and Lipid Mediators

Journal of Medical Virology, Volume 98, Issue 7, July 2026.
ABSTRACT Coronavirus disease 2019 (COVID‐19) exhibits a broad spectrum of severity, ranging from mild to critical cases. To reduce mortality and costs, tailored early interventions for at‐risk patients are essential. This study elucidates the association between longitudinal metabolomic profiles and COVID‐19 severity and progression.
Melissa Goris, Merys Valdez, Lieke Lamont, Wei Yang, Amy Harms, Naama Karu, Sabine Bos, Jelte Geerlings, Tom Ottenhoff, Roula Tsonaka, Anna HE Roukens, M. Sesmu Arbous, Simone A. Joosten, Thomas Hankemeier, Alida Kindt, In collaboration with BEAT‐COVID group, M.S. Arbous, B.M. van den Berg, S. Cannegieter, C.M. Cobbaert, A. van der Does, J.J.M. van Dongen, J. Eikenboom, M.C.M. Feltkamp, A. Geluk, J.J. Goeman, M. Giera, T. Hankemeier, M.H.M. Heemskerk, P.S. Hiemstra, C.H. Hokke, J.J. Janse, S.P. Jochems, S.A. Joosten, M. Kikkert, L. Lamont, J. Manniën, T.H.M. Ottenhoff, M.R. del Prado, N. Queralt Rosinach, M. Roestenberg, M. Roos, A.H.E. Roukens, H.H. Smits, E.J. Snijder, F.J.T. Staal, L.A. Trouw, R. Tsonaka, A. Verhoeven, L.G. Visser, J.J.C. de Vries, D.J. van Westerloo, J. Wigbers, H.J. van der Wijk, R.C. van Wissen, M. Wuhrer, M. Yazdanbakhsh, M. Zlei   +57 more
wiley   +1 more source

Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions

MedComm, Volume 7, Issue 7, July 2026.
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang   +4 more
wiley   +1 more source