Results 71 to 80 of about 2,126 (153)

Impact of systemic diseases on periodontal remodeling: Mechanisms, mediators, and clinical relevance

Periodontology 2000, EarlyView.
Abstract Background Periodontal remodeling is a continuous, adaptive process essential for maintaining the structural and functional integrity of periodontal tissues. While external factors such as bacterial biofilm, excessive forces, and poor oral hygiene are recognized triggers of periodontal pathologies, they do not fully explain their persistent ...
Michael Wolf, Ulrike Schulze‐Späte, Thomas Van Dyke, Stefan Wolfart, Thomas Dietrich, Alberto Ortiz, Zhuojun Wu, Joachim Jankowski   +7 more
wiley   +1 more source

Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis

Nature Communications, 2020
Biomarkers are needed for predicting the effectiveness of disease modifying antirheumatic drugs (DMARDs). Here, using functional lipid mediator profiling and deeply phenotyped patients with early rheumatoid arthritis (RA), we observe that peripheral ...
Esteban A. Gomez, Romain A. Colas, Patricia R. Souza, Rebecca Hands, Myles J. Lewis, Conrad Bessant, Costantino Pitzalis, Jesmond Dalli   +7 more
doaj   +1 more source

Maresin 1 biosynthesis during platelet–neutrophil interactions is organ-protective

, 2019
Unregulated acute inflammation can lead to collateral tissue injury in vital organs, such as the lung during the acute respiratory distress syndrome.
Dalli, Jesmond, Colby, Jennifer, Abdulnour, Raja-Elie, Timmons, Jack, Serhan, Charles, Colas, Romain, Petasis, Nicos, Krishnamoorthy, Nandini, Levy, Bruce, Tan, Sook Hwa   +9 more
core   +1 more source

Engineered probiotics platform for resolvin E1 biosynthesis confers protection against inflammatory disease

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
An engineered EcN‐RvE1 probiotic platform enables sustained biosynthesis of the pro‐resolving mediator RvE1 via inducible COX2/5‐LOX expression. Oral administration achieves long‐term intestinal persistence and systemic anti‐inflammatory effects in murine models of acute inflammation and colitis, offering a promising oral therapeutic strategy for ...
Xiaoxiao Li, Jiejing Lin, Qingqing Liu, Yiqun Wu, Qian Wu, Zewei Zhao, Yi Cai, Shengliang Lin, Zijie Zheng, Xinpan Chen, Jin Li, Zhonghan Yang   +11 more
wiley   +1 more source

Inflammaging: Experimental Insights and Translational Advances

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Inflammaging is a chronic, low‐grade, sterile inflammation associated with aging that contributes to age‐related diseases and functional decline. Recent research suggests that targeting inflammaging through senolytics, metabolic modulators, microbiome‐based interventions, and lifestyle modifications may help improve healthspan, reduce chronic disease ...
Andrea Cossarizza
wiley   +1 more source

The relationship between hepatocellular carcinoma and maresin 1

, 2021
Tıp Fakültesi, İç Hastalıkları Ana Bilim DalıGiriş ve Amaç: Karaciğer kanseri, kansere bağlı ölümlerde 4. sıradadır ve hepatoselüler karsinom (HCC), karaciğerin en sık görülen primer malign tümörüdür.
Yücel, Ayşe
core  

Omega‐3 Long‐Chain Polyunsaturated Fatty Acid Metabolite 16‐Hydroxydocosahexaenoic Acid Strengthens Non‐Small Cell Lung Cancer Radiosensitivity Through Peroxisome Proliferator‐Activated Receptor γ

Food Frontiers, Volume 7, Issue 4, July 2026.
This study revealed a novel mechanism by which ω‐3 LCPUFA metabolism regulated NSCLC cell radiosensitivity. Specific ω‐3 LCPUFA metabolite 16‐HDHA plasma levels were elevated in the radiosensitive NSCLC patients and enhanced the cytotoxic effects of radiation on NSCLC cells.
Mengqin Wang, Jiang Luo, Mini Zhang, Shuling Li, Jiawen Tang, Qingwei Wang, Yuzhu Wu, Ziyu Jiang, Conghua Xie, Yan Gong   +9 more
wiley   +1 more source

Maresin 1 Attenuates Radicular Pain Through the Inhibition of NLRP3 Inflammasome-Induced Pyroptosis via NF-κB Signaling

Frontiers in Neuroscience, 2020
BackgroundThe exposure of the nucleus pulposus (NP) causes an immune and inflammatory response, which is intrinsically linked to the pathogenesis of radicular pain. As a newly discovered pro-resolving lipid mediator, maresin 1 (MaR1) could exert powerful
Yi-hao Wang, Yi-hao Wang, Yan Li, Jun-nan Wang, Qing-xiang Zhao, Jin Jin, Shuang Wen, Si-cong Wang, Tao Sun   +8 more
doaj   +1 more source

Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages

, 2019
Macrophages are central in coordinating immune responses, tissue repair, and regeneration, with different subtypes being associated with inflammation-initiating and proresolving actions.
Chiang, Nan, Dalli, Jesmond, Spur, Bernd, Rodriguez, Ana, Serhan, Charles, Petasis, Nicos, Riley, Ian, Vlasakov, Iliyan   +7 more
core   +1 more source

Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity

Nature Communications, 2018
Proinflammatory eicosanoids (prostaglandins and leukotrienes) and specialized pro-resolving mediators (SPM) are temporally regulated during infections.
Oliver Werz, Jana Gerstmeier, Stephania Libreros, Xavier De la Rosa, Markus Werner, Paul C. Norris, Nan Chiang, Charles N. Serhan   +7 more
doaj   +1 more source