Results 71 to 80 of about 209 (125)

Divergent Inflammatory and Bioenergetic Metabolomic Signatures Distinguish Methamphetamine‐Associated From Idiopathic Pulmonary Arterial Hypertension

Pulmonary Circulation, Volume 16, Issue 3, July 2026.
ABSTRACT Methamphetamine‐associated pulmonary arterial hypertension (Meth‐APAH) is an increasingly recognized cause of pulmonary arterial hypertension (PAH) and is associated with worse outcomes than idiopathic PAH (IPAH). Although both share histopathologic features of pulmonary vascular remodeling, the molecular basis for their clinical divergence ...
Hannah K. Robertson, Emma Yuguchi, Ian Gurholt, William C. Nichols, Nick H. Kim, Timothy Fernandes, Atul Malhotra, Mona Alotaibi   +7 more
wiley   +1 more source

Tailored Porous Bimetallic Nanozyme Platform for Full‐Cycle Therapeutics of Intestinal Ischemia/Reperfusion

Advanced Science, Volume 13, Issue 34, 19 June 2026.
ABSTRACT Intestinal ischemia/reperfusion (I/R) injury presents a biphasic pathology: an acute oxidative‐inflammatory phase leading to organ failure, and a recovery phase marked by mucosal dysfunction and bacterial translocation. The developed MPB@TA‐Cu‐Ma nanocomposite functions as a dual‐phase therapeutic platform with significant efficacy. It rapidly
Chenghao Qiu, Wenjing Xian, Mengxue Wang, Guozhi Zhao, Yanhuo Zhang, Zhiyu Zhou, Bo Sheng, Zhuo Zhen, Xie Liu, Shouwen Diao, Mengwei Tu, Chen Qiu, Huixian Wang, Jianbo Zhang, Peng Zhu, Tong Li   +15 more
wiley   +1 more source

Maresin 1 Attenuates Radicular Pain Through the Inhibition of NLRP3 Inflammasome-Induced Pyroptosis via NF-κB Signaling

Frontiers in Neuroscience, 2020
BackgroundThe exposure of the nucleus pulposus (NP) causes an immune and inflammatory response, which is intrinsically linked to the pathogenesis of radicular pain. As a newly discovered pro-resolving lipid mediator, maresin 1 (MaR1) could exert powerful
Yi-hao Wang, Yi-hao Wang, Yan Li, Jun-nan Wang, Qing-xiang Zhao, Jin Jin, Shuang Wen, Si-cong Wang, Tao Sun   +8 more
doaj   +1 more source

Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity

Nature Communications, 2018
Proinflammatory eicosanoids (prostaglandins and leukotrienes) and specialized pro-resolving mediators (SPM) are temporally regulated during infections.
Oliver Werz, Jana Gerstmeier, Stephania Libreros, Xavier De la Rosa, Markus Werner, Paul C. Norris, Nan Chiang, Charles N. Serhan   +7 more
doaj   +1 more source

Maresin 1 alleviates myocardial ischemia-reperfusion injury in rats by suppressing inflammation

European Journal of Histochemistry
Myocardial ischemia-reperfusion injury (MIRI) induces severe inflammatory damage to cardiac tissue, leading to structural impairment and functional decline.
Hongkai Xiao, Jinghu Liu, Qinhong Cai, Siyu Liang, Zhitao Hu, Xiaochao Chen   +5 more
doaj   +1 more source

Maresin‐1 ameliorates hypertensive vascular remodeling through its receptor LGR6

MedComm
Hypertensive vascular remodeling is defined as the changes in vascular function and structure induced by persistent hypertension. Maresin‐1 (MaR1), one of metabolites from Omega‐3 fatty acids, has been reported to promote inflammation resolution in ...
Zheng Yin, Jishou Zhang, Mengmeng Zhao, Shanshan Peng, Jing Ye, Jianfang Liu, Yao Xu, Shuwan Xu, Wei Pan, Cheng Wei, Juan‐Juan Qin, Jun Wan, Menglong Wang   +12 more
doaj   +1 more source

The Pro-resolving Mediators Maresin 1, Maresin 2 and Annexin A1 in Maintenance of Ocular Surface Health

, 2022
The omega-3 fatty acids Maresin 1 and Maresin 2 and the protein Annexin A1 are pro-resolving mediators which play an active role in resolution of inflammation. The mediators enhance elimination of apoptotic cells, activation of immune cells and limit invasion of leukocytes.
openaire   +2 more sources

Maresin 1 mitigates renal ischemia/reperfusion injury in mice via inhibition of the TLR4/MAPK/ NF-κB pathways and activation of the Nrf2 pathway

Drug Design, Development and Therapy, 2019
Yun Qiu, Yichen Wu, Hongmei Zhao, Hong Sun, Sumin Gao Department of Emergency Medicine, The Affiliated Huaian No 1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu Province, China Background: Inflammation and oxidative ...
Qiu Y, Wu Y, Zhao H, Sun H, Gao S
doaj  

Serum biomarker screening and metabolic profiling analysis of nonalcoholic fatty liver disease patients using untargeted metabolomics and machine learning techniques

Frontiers in Molecular Biosciences
Background and ObjectiveNon-alcoholic fatty liver disease (NAFLD) represents the most prevalent chronic hepatic metabolic disorder globally. Without timely intervention, it can progress to non-alcoholic steatohepatitis (NASH), liver fibrosis, and even ...
Lijuan Dan, Huan Shi, Lina Cao, Xiuyan Li, Lirui Kong, Xiaojie You, Wenping Liu, Yanwei Hao, Dong Wang, Hongfei Song, Jie Mu, Qiao Li   +11 more
doaj   +1 more source

Maresin-1 Ameliorates Chronic Unpredictable Stress-Induced Depressive-like Behaviors Associated with Dynamic Modulation of Hippocampal Microglial Activity and TSPO PET Signals

Biomedicines
Background/Objectives: Maresin-1 (MaR1), a specialized pro-resolving mediator (SPM) derived from omega-3 fatty acids, has demonstrated potent anti-inflammatory and pro-resolving properties.
Anhai Zheng, Tian Qiu, Lei Shi, Lixia Wang, Zhu Xia, Zhiping Peng, Li Kuang, Jiamei Guo   +7 more
doaj   +1 more source