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Total synthesis and bioactivities of two proposed structures of maresin
Total synthesis and bioactivities of two proposed structures of maresinMaresin is a potent anti-inflammatory lipid mediator derived from docosahexaenoic acid (DHA). A highly convergent total synthesis of two proposed structures of C7-epimeric maresins from the four known fragments was achieved in 17 steps. The three key coupling reactions were the BF3-mediated alkyne attack on the epoxide, chiral titanium complex-promoted
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Maresin 1 Ameliorates Diabetic Kidney Disease in Mice by Promoting Macrophage M2 Polarization
Mediators of InflammationYueli Pu +8 more
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Maresin-1 and Inflammatory Disease [PDF]
International Journal of Molecular Sciences, 2022 Inflammation is an essential action to protect the host human body from external, harmful antigens and microorganisms. However, an excessive inflammation reaction sometimes exceeds tissue damage and can disrupt organ functions. Therefore, anti-inflammatory action and resolution mechanisms need to be clarified.
Natsuko Saito-Sasaki +2 more
exaly +3 more sources
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Maresin-1 resolution with RORα and LGR6
Progress in Lipid Research, 2020Maresin-1, a pro-resolving lipid mediator, is drawing a great deal of attention in receptor pharmacology, largely because two distinct types of receptor molecules have been reported as the targets of maresin-1. One is retinoic acid-related orphan receptor α (RORα) and the other is leucine-rich repeat domain-containing G protein-coupled receptor 6 (LGR6)
Dong-Soon Im
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Stereoselective synthesis of maresin 1
Tetrahedron Letters, 2015Abstract Maresin 1 is a potent anti-inflammatory and pro-resolving lipid mediator derived from docosahexaenoic acid. The total synthesis of maresin 1 is achieved in 10 steps and in 7% overall yield. The Evans–Nagao aldol reaction between (2E,4E)-5-bromopenta-2,4-dienal and different chiral auxiliaries is investigated.
Trond Vidar Hansen, Marius Aursnes
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Synthesis of maresin 1 and (7S)-isomer
Tetrahedron Letters, 2014Maresin 1 (with the 7R carbon) and (7S)-maresin 1 were synthesized stereoselectively. The conjugated triene system was constructed by Pd-catalyzed coupling of the trans cis-dienylborane (the C10–C22 part) with the trans vinyl iodide corresponding to the C1–C9 part.
Narihito Ogawa, Yuichi Kobayashi
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Maresin 1 biosynthesis during platelet–neutrophil interactions is organ-protective [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2014 Significance Neutrophil accumulation is fundamental to acute inflammation. In response to tissue injury, circulating neutrophil–platelet aggregates (N-PAs) form for secondary capture. Counterregulation of acute inflammatory processes by specialized proresolving mediators is essential to mitigate collateral injury to healthy bystander ...
Jesmond Dalli +2 more
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Maresin 1 intervention reverses experimental pulmonary arterial hypertension in mice
British Journal of Pharmacology, 2022Background and PurposePulmonary arterial hypertension (PAH) is a pulmonary vasculature obstructive disease that leads to right heart failure and death. Maresin 1 is an endogenous lipid mediator known to promote inflammation resolution. However, the effect of Maresin 1 on PAH remains unclear.Experimental ApproachThe serum Maresin 1 concentration was ...
Aaron Scott, Hui Li
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Relationship between pancreatic cancer and Maresin 1
Journal of Current Hematology & Oncology Research, 2023Aims: Pancreatic cancer is the 4th most common cause of death from cancer. In addition, pancreatic cancer is the most common primary malignant tumor of the pancreas. There are many risk factors for pancreatic cancer, including age, certain genetic syndromes, smoking, diabetes, alcohol abuse and obesity.
Hakan Varol +5 more
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Maresin-1 impairs cutaneous wound healing response
ImmunoHorizonsAbstract Maresin-1 is a derivative of docosahexaenoic acid with strong anti-inflammatory action in various disease models. However, these effects may not always be beneficial. In instances like cutaneous diseases in which wound healing is important, inflammation is required.
Natsuko Saito-Sasaki +2 more
exaly +3 more sources