Results 51 to 60 of about 2,016 (189)
Maresin 1 Ameliorates Diabetic Kidney Disease in Mice by Promoting Macrophage M2 Polarization [PDF]
Mediators of InflammationYueli Pu +8 more
doaj +2 more sources
Identification and Actions of the Maresin 1 Metabolome in Infectious Inflammation [PDF]
The Journal of Immunology, 2016 Abstract Maresin 1 (MaR1) is an immunoresolvent that governs resolution of acute inflammation, and its local metabolism in the context of infectious inflammation is of interest. In this study, we investigated the MaR1 metabolome in infectious exudates and its bioactions in regulating leukocyte responses in the context of bacterial ...
Romain A Colas +6 more
openaire +3 more sources
Unified nexus of macrophages and maresins in cardiac reparative mechanisms [PDF]
The FASEB Journal, 2018 ABSTRACT Macrophages are immune‐sensing “big eater” phagocytic cells responsible for an innate, adaptive, and regenerative response. After myocardial infarction, macrophages predominantly clear the deceased cardiomyocyte apoptotic or necrotic neutrophils to develop a regenerative and reparative program with the ...
Jeevan Kumar, Jadapalli +1 more
openaire +2 more sources
Cysteinyl maresins regulate the prophlogistic lung actions of cysteinyl leukotrienes [PDF]
Journal of Allergy and Clinical Immunology, 2020 Cysteinyl leukotrienes (CysLTs) are potent prophlogistic mediators in asthmatic patients; however, inhibition of CysLT receptor 1 is not a consistently effective treatment, suggesting additional regulatory mechanisms. Other cysteinyl-containing lipid mediators (LMs) derived from docosahexaenoic acid, namely maresin conjugates in tissue regeneration ...
Bruce D. Levy +7 more
openaire +2 more sources
Frontiers in Pharmacology, 2021 Sepsis-associated acute kidney injury (S-AKI) is a common complication in hospitalized and critically ill patients, which increases the risk of multiple comorbidities and is associated with extremely high mortality.
Jiameng Li +6 more
doaj +1 more source
Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions [PDF]
Journal of Experimental Medicine, 2008 The endogenous cellular and molecular mechanisms that control acute inflammation and its resolution are of wide interest. Using self-resolving inflammatory exudates and lipidomics, we have identified a new pathway involving biosynthesis of potent antiinflammatory and proresolving mediators from the essential fatty acid docosahexaenoic acid (DHA) by ...
Serhan, Charles N. +7 more
openaire +4 more sources
Specialized pro-resolving mediator Maresin 1 attenuates pain in a mouse model of osteoarthritis [PDF]
Osteoarthritis and CartilageYu-Ru V Shih +2 more
exaly +2 more sources
DHA- and EPA-derived resolvins, protectins, and maresins in airway inflammation [PDF]
European Journal of Pharmacology, 2016 Essential fatty acids can serve as important regulators of inflammation. A new window into mechanisms for the resolution of inflammation was opened with the identification and structural elucidation of mediators derived from these fatty acids with pro-resolving capacity.
Melody G, Duvall, Bruce D, Levy
openaire +2 more sources
The Role of Maresins in Inflammatory Pain: Function of Macrophages in Wound Regeneration [PDF]
International Journal of Molecular Sciences, 2019 Although acute inflammatory responses are host-protective and generally self-limited, unresolved and delayed resolution of acute inflammation can lead to further tissue damage and chronic inflammation. The mechanism of pain induction under inflammatory conditions has been studied extensively; however, the mechanism of pain resolution is not fully ...
Sung-Min Hwang +3 more
openaire +2 more sources
Современная ревматология, 2016 Inflammation is the most important element in the pathogenesis of major human diseases. It determines the fundamental value of anti-inflammatory therapy in the modern concept of targeted pathogenetic treatment.
A. E. Karateev, T. L. Aleinikova
doaj +1 more source