Results 11 to 20 of about 209 (125)

Protective Potential of Maresins in Cardiovascular Diseases

Frontiers in Cardiovascular Medicine, 2022
Cardiovascular diseases are the leading causes of global mortality. Growing evidence suggests that unresolved inflammation contributes to the chronicity, progression and morbidity of many cardiovascular diseases, thus emphasizing the urgent need to ...
Min Liu, Huixiang He, Lihong Chen
doaj   +3 more sources

Administration of Maresin-1 ameliorates the physiopathology of experimental autoimmune encephalomyelitis [PDF]

Journal of Neuroinflammation, 2022
Background Resolution of inflammation is an active and regulated process that leads to the clearance of cell debris and immune cells from the challenged tissue, facilitating the recovery of homeostasis.
Alba Sánchez-Fernández, Stephanie Zandee, Mauricio Mastrogiovanni, Marc Charabati, Homero Rubbo, Alexandre Prat, Rubèn López-Vales   +6 more
doaj   +5 more sources

The Protective Effects of Maresin 1 in the OVA-Induced Asthma Mouse Model [PDF]

Mediators of Inflammation, 2021
Asthma is a chronic inflammatory disease that cannot be cured. Maresin 1 (MaR1) is a specific lipid synthesized by macrophages that exhibits powerful anti-inflammatory effects in various inflammatory diseases.
Guochun Ou, Qin Liu, Chengxiu Yu, Xiaoju Chen, Wenbo Zhang, Yong Chen, Tao Wang, Yongqiang Luo, Guolu Jiang, Mingmei Zhu, Hongmei Li, Mei Zeng   +11 more
doaj   +3 more sources

Decreased Plasma Maresin 1 Concentration Is Associated with Diabetic Foot Ulcer [PDF]

Mediators of Inflammation, 2020
Aims. To assess the maresin 1 (MaR1) contents in type 2 diabetic patients with or without diabetic foot ulcer and to analyze the association of MaR1 concentrations with several metabolism-related parameters. Methods.
Tian Miao, Bangliang Huang, Niexia He, Lihua Sun, Guangsheng Du, Xiaoli Gong, Yong Xu, Yi Zheng, Hongting Zheng, Hua Qu   +9 more
doaj   +3 more sources

Maresin 1 Mitigates Inflammatory Response and Protects Mice from Sepsis [PDF]

Mediators of Inflammation, 2016
Sepsis, frequently caused by infection of bacteria, is considered as an uncontrollable systematic inflammation response syndrome (SIRS). Maresin 1 (Mar1) is a new proresolving mediator with potent anti-inflammatory effect in several animal models ...
Ruidong Li, Yaxin Wang, Zhijun Ma, Muyuan Ma, Di Wang, Gengchen Xie, Yuping Yin, Peng Zhang, Kaixiong Tao   +8 more
doaj   +3 more sources

Maresins: The Mainstay in Periodontal Resolution [PDF]

Cureus, 2022
Not much was known about the resolution of inflammation until the recent past when significant breakthroughs led to the unveiling of the exact mechanism of this. It is now known that the resolution of inflammation involves specific mediators of resolution such as lipoxins, protectins, resolvins, and maresins, making it an active process.
Gireddy, Hima Bindu, Rajaram, Haripriya, Koduganti, Rekha R, Ambati, Manasa, R, Anilkumar, Harika, Tata Sai Lakshmi   +5 more
openaire   +2 more sources

Synthesis of Optically Active Maresin 2 and Maresin 2n-3 DPA [PDF]

Synlett, 2020
AbstractMaresins are among the most potent antiinflammatory lipid metabolites. We report stereoselective syntheses of maresin 2 and maresin 2n-3 DPA. The anti-diol was constructed through epoxide ring opening of an optically active β,γ-epoxy aldehyde, synthesized in situ by Swern oxidation of the corresponding alcohol.
Narihito Ogawa, Takahito Amano, Yuichi Kobayashi   +2 more
openaire   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Stereoselective Synthesis of Maresin-Like Lipid Mediators [PDF]

Synlett, 2019
14S,22-Dihydroxy-docosa-4Z,7Z,10Z,12E,16Z,19Z-hexaenoic acid (maresin-L1) and 14R,22-dihydroxy-docosa-4Z,7Z,10Z, 12E,16Z,19Z-hexaenoic acid (maresin-L2) were chemically synthesized. They were identical to activated macrophage-produced counterparts and their total synthesis was highly stereoselective, as revealed by chiral LC-UV-MS/MS analysis.
Song Hong, Yan Lu, Masao Morita, Shun Saito, Yuichi Kobayashi, Bokkyoo Jun, Nicolas Bazan, Xiaoming Xu, Yapin Wang   +8 more
openaire   +3 more sources