Results 21 to 30 of about 3,920 (194)
Molecules, 2022 Specialized pro-resolving mediators (SPMs) are lipid mediators derived from poly-unsaturated fatty acids (PUFAs) which have been demonstrated to have an important role in the inflammation environment, preventing an overreaction of the organism and ...
Mariarosaria Valente +4 more
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Molecular pathobiology of scleritis and its therapeutic implications [PDF]
International Journal of Ophthalmology, 2020 Scleritis and other autoimmune diseases are characterized by an imbalance in the levels of pro-inflammatory and anti-inflammatory molecules with the balance tilted more towards the former due to the failure of recognition of self.
Undurti N Das
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Frontiers in Immunology, 2020 Obesity is a major independent risk factor for increased morbidity and mortality upon infection with Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2), which is responsible for the current coronavirus disease pandemic (COVID-19).
Anandita Pal +4 more
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Bioactive lipid-based therapeutic approach to COVID-19 and other similar infections
Archives of Medical Science, 2021 COVID-19 is caused by SARS-CoV-2 infection. Epithelial and T, NK, and other immunocytes release bioactive lipids especially arachidonic acid (AA) in response to microbial infections to inactivate them and upregulate the immune system.
Undurti N. Das
doaj +1 more source
Antioxidants, 2020 Heart disease is the number one mortality disease in the world. In particular, cardiac fibrosis is considered as a major factor causing myocardial infarction and heart failure. In particular, oxidative stress is a major cause of heart fibrosis.
Gyeoung Jin Kang +2 more
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Administration of Maresin-1 ameliorates the physiopathology of experimental autoimmune encephalomyelitis [PDF]
Journal of Neuroinflammation, 2022 Abstract Background Resolution of inflammation is an active and regulated process that leads to the clearance of cell debris and immune cells from the challenged tissue, facilitating the recovery of homeostasis. This physiological response is coordinated by endogenous bioactive lipids known as specialized pro-resolving ...
Sánchez Fernández, Alba +6 more
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Endogenous inhibitory mechanisms in asthma
Journal of Allergy and Clinical Immunology: Global, 2023 Endogenous inhibitory mechanisms promote resolution of inflammation, enhance tissue repair and integrity, and promote homeostasis in the lung. These mechanisms include steroid hormones, regulatory T cells, IL-10, prostaglandin E2, prostaglandin I2 ...
Sergio E. Chiarella, MD +1 more
doaj +1 more source
Stereoselective Synthesis of Maresin-Like Lipid Mediators [PDF]
Synlett, 2019 14S,22-Dihydroxy-docosa-4Z,7Z,10Z,12E,16Z,19Z-hexaenoic acid (maresin-L1) and 14R,22-dihydroxy-docosa-4Z,7Z,10Z, 12E,16Z,19Z-hexaenoic acid (maresin-L2) were chemically synthesized. They were identical to activated macrophage-produced counterparts and their total synthesis was highly stereoselective, as revealed by chiral LC-UV-MS/MS analysis.
Song Hong +8 more
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International Journal of Molecular Sciences, 2022 Specialized pro-resolving mediators (SPMs), including Maresins (MaR)-1 and 2, contribute to tear film homeostasis and resolve conjunctival inflammation. We investigated MaR2′s signaling pathways in goblet cells (GC) from rat conjunctiva. Agonist-induced [Ca2+]i and high-molecular weight glycoconjugate secretion were measured. MaR2 increased [Ca2+]i and
Markus V. Olsen +6 more
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The Protective Effects of Maresin 1 in the OVA‐Induced Asthma Mouse Model [PDF]
Mediators of Inflammation, 2021 Asthma is a chronic inflammatory disease that cannot be cured. Maresin 1 (MaR1) is a specific lipid synthesized by macrophages that exhibits powerful anti‐inflammatory effects in various inflammatory diseases. The goal of this study was to evaluate the effect of MaR1 on allergic asthma using an ovalbumin‐ (OVA‐) induced asthma model. Thirty BALB/c mice
Guochun Ou +11 more
openaire +3 more sources