Results 21 to 30 of about 3,018 (169)

Omega-3 DHA as a blank canvas: A molecular approximation to how lipid mediators modulate LGR6 in inflammation resolution. [PDF]

Protein Sci
Abstract The leucine‐rich repeat‐containing G protein‐coupled receptor 6 (LGR6) has a potential role in inflammation resolution and different cancer processes. In this study, we employed computational techniques, including molecular docking and molecular dynamics simulations of mammalian membrane‐embeded systems, to understand the activation mechanism ...
Pérez-Sánchez Á, Garcia-Viloca M, González-Lafont À, Lluch JM.   +3 more
europepmc   +2 more sources

Synthesis of Optically Active Maresin 2 and Maresin 2n-3 DPA [PDF]

Synlett, 2020
AbstractMaresins are among the most potent antiinflammatory lipid metabolites. We report stereoselective syntheses of maresin 2 and maresin 2n-3 DPA. The anti-diol was constructed through epoxide ring opening of an optically active β,γ-epoxy aldehyde, synthesized in situ by Swern oxidation of the corresponding alcohol.
Narihito Ogawa, Takahito Amano, Yuichi Kobayashi   +2 more
openaire   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Specialized Pro-Resolving Mediators in Neuroinflammation: Overview of Studies and Perspectives of Clinical Applications

Molecules, 2022
Specialized pro-resolving mediators (SPMs) are lipid mediators derived from poly-unsaturated fatty acids (PUFAs) which have been demonstrated to have an important role in the inflammation environment, preventing an overreaction of the organism and ...
Mariarosaria Valente, Marta Dentoni, Fabrizio Bellizzi, Fedra Kuris, Gian Luigi Gigli   +4 more
doaj   +1 more source

Molecular pathobiology of scleritis and its therapeutic implications [PDF]

International Journal of Ophthalmology, 2020
Scleritis and other autoimmune diseases are characterized by an imbalance in the levels of pro-inflammatory and anti-inflammatory molecules with the balance tilted more towards the former due to the failure of recognition of self.
Undurti N Das
doaj   +1 more source

Bioactive lipid-based therapeutic approach to COVID-19 and other similar infections

Archives of Medical Science, 2021
COVID-19 is caused by SARS-CoV-2 infection. Epithelial and T, NK, and other immunocytes release bioactive lipids especially arachidonic acid (AA) in response to microbial infections to inactivate them and upregulate the immune system.
Undurti N. Das
doaj   +1 more source

Administration of Maresin-1 ameliorates the physiopathology of experimental autoimmune encephalomyelitis [PDF]

Journal of Neuroinflammation, 2022
Abstract Background Resolution of inflammation is an active and regulated process that leads to the clearance of cell debris and immune cells from the challenged tissue, facilitating the recovery of homeostasis. This physiological response is coordinated by endogenous bioactive lipids known as specialized pro-resolving ...
Sánchez Fernández, Alba, Zandee, Stephanie, Mastrogiovanni, Mauricio, Charabati, Marc, Rubbo, Homero, Prat, Alexandre, López Vales, Rubén   +6 more
openaire   +5 more sources

Obesity-Driven Deficiencies of Specialized Pro-resolving Mediators May Drive Adverse Outcomes During SARS-CoV-2 Infection

Frontiers in Immunology, 2020
Obesity is a major independent risk factor for increased morbidity and mortality upon infection with Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2), which is responsible for the current coronavirus disease pandemic (COVID-19).
Anandita Pal, Kymberly M. Gowdy, Kenneth J. Oestreich, Melinda Beck, Saame Raza Shaikh   +4 more
doaj   +1 more source

Endogenous inhibitory mechanisms in asthma

Journal of Allergy and Clinical Immunology: Global, 2023
Endogenous inhibitory mechanisms promote resolution of inflammation, enhance tissue repair and integrity, and promote homeostasis in the lung. These mechanisms include steroid hormones, regulatory T cells, IL-10, prostaglandin E2, prostaglandin I2 ...
Sergio E. Chiarella, MD, Peter J. Barnes, MD   +1 more
doaj   +1 more source

Signaling Pathways Used by the Specialized Pro-Resolving Mediator Maresin 2 Regulate Goblet Cell Function: Comparison with Maresin 1

International Journal of Molecular Sciences, 2022
Specialized pro-resolving mediators (SPMs), including Maresins (MaR)-1 and 2, contribute to tear film homeostasis and resolve conjunctival inflammation. We investigated MaR2′s signaling pathways in goblet cells (GC) from rat conjunctiva. Agonist-induced [Ca2+]i and high-molecular weight glycoconjugate secretion were measured. MaR2 increased [Ca2+]i and
Markus V. Olsen, Anne V. Lyngstadaas, Jeffrey A. Bair, Robin R. Hodges, Tor P. Utheim, Charles N. Serhan, Darlene A. Dartt   +6 more
openaire   +2 more sources