Results 11 to 20 of about 3,920 (194)
mBio, 2022 Influenza A virus (IAV) infections are a leading cause of mortality worldwide. Excess mortality during IAV epidemics and pandemics is attributable to secondary bacterial infections, particularly pneumonia caused by Streptococcus pneumoniae.
Luciana P. Tavares +9 more
doaj +2 more sources
Unified nexus of macrophages and maresins in cardiac reparative mechanisms [PDF]
The FASEB Journal, 2018 ABSTRACT Macrophages are immune‐sensing “big eater” phagocytic cells responsible for an innate, adaptive, and regenerative response. After myocardial infarction, macrophages predominantly clear the deceased cardiomyocyte apoptotic or necrotic neutrophils to develop a regenerative and reparative program with the ...
Jeevan K Jadapalli, G. Halade
semanticscholar +3 more sources
DHA- and EPA-derived resolvins, protectins, and maresins in airway inflammation [PDF]
European Journal of Pharmacology, 2015 Essential fatty acids can serve as important regulators of inflammation. A new window into mechanisms for the resolution of inflammation was opened with the identification and structural elucidation of mediators derived from these fatty acids with pro ...
M. Duvall, B. Levy
semanticscholar +3 more sources
Cys-LTs’ Pro-phlogistic Lung Actions Are Regulated by Cys-Maresins [PDF]
Journal of Allergy and Clinical Immunology, 2019 Background: Cysteinyl leukotrienes (CysLTs) are potent pro-phlogistic mediators in asthma; however, inhibition of CysLT1 receptors is not a consistently effective treatment, suggesting additional regulatory mechanisms.
B. Levy +7 more
semanticscholar +3 more sources
Maresins: anti-inflammatory pro-resolving mediators with therapeutic potential.
European review for medical and pharmacological sciences, 2020 Although inflammation is protective of the body, uncontrolled acute inflammatory reactions may inflict tissue damage and lead to chronic inflammation. There is a fast-growing research interest in mechanisms that mediate regression of inflammation and actions of anti-inflammatory factors.
Q-F Li +4 more
semanticscholar +3 more sources
MoleculesInflammatory lung diseases (ILDs) represent a global public health crisis characterized by escalating prevalence, significant morbidity, and substantial mortality.
Ángel Ortega +11 more
doaj +2 more sources
Maresin-1 and Inflammatory Disease [PDF]
International Journal of Molecular Sciences, 2022 Inflammation is an essential action to protect the host human body from external, harmful antigens and microorganisms. However, an excessive inflammation reaction sometimes exceeds tissue damage and can disrupt organ functions. Therefore, anti-inflammatory action and resolution mechanisms need to be clarified.
Saito-Sasaki, Natsuko +2 more
openaire +2 more sources
MoleculesThe resolution of inflammation is the primary domain of specialised pro-resolving mediators (SPMs), which include resolvins, protectins, and their forms synthesised under the influence of aspirin and the maresins.
Ewelina Honkisz-Orzechowska +3 more
doaj +2 more sources
Synthesis of Optically Active Maresin 2 and Maresin 2n-3 DPA [PDF]
Synlett, 2020 AbstractMaresins are among the most potent antiinflammatory lipid metabolites. We report stereoselective syntheses of maresin 2 and maresin 2n-3 DPA. The anti-diol was constructed through epoxide ring opening of an optically active β,γ-epoxy aldehyde, synthesized in situ by Swern oxidation of the corresponding alcohol.
Narihito Ogawa +2 more
openaire +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source