Results 31 to 40 of about 3,920 (194)
Biomedicines, 2022 Introduction: Polycystic ovary syndrome (PCOS) is an endocrinological disorder that affects 5–15% of women of their reproductive age and is a frequent cause of infertility. Major symptoms include hyperandrogenism, ovulatory dysfunction, and often obesity
Pedro-Antonio Regidor +6 more
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Frontiers in Psychiatry, 2020 Inflammation has been identified as one of the main pathophysiological mechanisms underlying neuropsychiatric and neurodegenerative disorders. Despite the role of inflammation in those conditions, there is still a lack of effective anti-inflammatory ...
Juliette Giacobbe +4 more
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Identification and Actions of the Maresin 1 Metabolome in Infectious Inflammation [PDF]
The Journal of Immunology, 2016 Abstract Maresin 1 (MaR1) is an immunoresolvent that governs resolution of acute inflammation, and its local metabolism in the context of infectious inflammation is of interest. In this study, we investigated the MaR1 metabolome in infectious exudates and its bioactions in regulating leukocyte responses in the context of bacterial ...
Romain A Colas +6 more
openaire +3 more sources
Prostanoids and Resolution of Inflammation – Beyond the Lipid-Mediator Class Switch
Frontiers in Immunology, 2021 Bioactive lipid mediators play a major role in regulating inflammatory processes. Herein, early pro-inflammatory phases are characterized and regulated by prostanoids and leukotrienes, whereas specialized pro-resolving mediators (SPM), including lipoxins,
Tobias Schmid +4 more
doaj +1 more source
Lipoxins as biomarkers of lupus and other inflammatory conditions
Lipids in Health and Disease, 2011 Inflammatory events persist in systemic lupus erythematosus (lupus) despite the use of anti-inflammatory (both steroidal and non-steroidal) and immunosuppressive drugs leading to delay in the healing/repair process and so tissue/organ damage continues ...
Das Undurti N
doaj +1 more source
PLoS ONE, 2014 Maresins are a new family of anti-inflammatory and pro-resolving lipid mediators biosynthesized from docosahexaenoic acid (DHA) by macrophages. Here we identified a novel pro-resolving product, 13R,14S-dihydroxy-docosahexaenoic acid (13R,14S-diHDHA), produced by human macrophages.
Deng, Bin +6 more
openaire +6 more sources
Ageing: Is there a role for arachidonic acid and other bioactive lipids? A review
Journal of Advanced Research, 2018 Ageing is inevitable. Recent studies suggest that it could be delayed. Low-grade systemic inflammation is seen in type 2 diabetes mellitus, hypertension and endothelial dysfunction that are common with increasing age.
Undurti N. Das
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Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages [PDF]
Proceedings of the National Academy of Sciences, 2016 Significance We recently uncovered a family of macrophage-derived molecules, coined maresin conjugates in tissue regeneration, that regulate the system’s ability to clear bacteria as well as repair and regenerate damaged tissues. In the present study, we identified enzymes involved in the formation of these potent molecules in human ...
Dalli, Jesmond +7 more
openaire +4 more sources
Frontiers in PharmacologySepsis-associated lung injury (SALI) is a critical condition with high mortality. Current therapies are limited, necessitating novel approaches. This review highlights the potential of exogenous Specialized Pro-resolving Mediators (SPMs), including ...
Jiwei Shen +26 more
doaj +1 more source
Biochimica et Biophysica Acta, 2014 Acute inflammatory responses are protective, yet without timely resolution can lead to chronic inflammation and organ fibrosis. A systems approach to investigate self-limited (self-resolving) inflammatory exudates in mice and structural elucidation ...
C. Serhan +4 more
semanticscholar +1 more source