Results 1 to 10 of about 4,562 (115)

The Role of Resolvins, Protectins and Marensins in Non-Alcoholic Fatty Liver Disease (NAFLD)

Biomolecules, 2021
Increased triacylglycerols’ (TAG) synthesis, insulin resistance, and prolonged liver lipid storage might lead to the development of non-alcoholic fatty liver disease (NAFLD).
Ewa Stachowska, Dominika Maciejewska-Markiewicz, Ewa Stachowska   +2 more
exaly   +3 more sources

Resolvins, Protectins, and Maresins: DHA-Derived Specialized Pro-Resolving Mediators, Biosynthetic Pathways, Synthetic Approaches, and Their Role in Inflammation

Molecules, 2022
Marine organisms are an important source of natural products with unique and diverse chemical structures that may hold the key for the development of novel drugs.
Narcisa Bandarra, Amelia P Rauter, Bandarra Narcisa   +2 more
exaly   +3 more sources

Resolution of Inflammation after Skeletal Muscle Ischemia–Reperfusion Injury: A Focus on the Lipid Mediators Lipoxins, Resolvins, Protectins and Maresins

Antioxidants, 2022
Skeletal muscle ischemia reperfusion is very frequent in humans and results not only in muscle destruction but also in multi-organ failure and death via systemic effects related to inflammation and oxidative stress.
Cindy Barnig, Anne Lejay, Gaëtan Lutzweiler   +2 more
exaly   +3 more sources

Macrophages: their role in immunity and their relationship with fatty acids in health and disease [PDF]

Frontiers in Immunology
The intricate interplay between macrophage biology and lipid metabolism has emerged as a critical determinant of metabolic homeostasis, disease progression and pathogenesis.
Mayte Rueda-Munguía, Mayte Rueda-Munguía, Luis Alberto Luévano-Martínez, Luis Alberto Luévano-Martínez, Gerardo García-Rivas, Gerardo García-Rivas, Elena Cristina Castillo, Elena Cristina Castillo, Omar Lozano, Omar Lozano   +9 more
doaj   +2 more sources

Omega-3 fatty acid-derived resolvins and protectins in inflammation resolution and leukocyte functions: targeting novel lipid mediator pathways in mitigation of acute kidney injury

Frontiers in Immunology, 2013
Inflammation, in conjunction with leukocytes, plays a key role in most acute kidney injury (AKI). Non-resolving renal inflammation leads to fibrosis and chronic renal failure.
Song Hong
exaly   +3 more sources

Specialized Pro-Resolving Mediators in Neuroinflammation: Overview of Studies and Perspectives of Clinical Applications

Molecules, 2022
Specialized pro-resolving mediators (SPMs) are lipid mediators derived from poly-unsaturated fatty acids (PUFAs) which have been demonstrated to have an important role in the inflammation environment, preventing an overreaction of the organism and ...
Mariarosaria Valente, Marta Dentoni, Fabrizio Bellizzi, Fedra Kuris, Gian Luigi Gigli   +4 more
doaj   +1 more source

Bioactive lipid-based therapeutic approach to COVID-19 and other similar infections

Archives of Medical Science, 2021
COVID-19 is caused by SARS-CoV-2 infection. Epithelial and T, NK, and other immunocytes release bioactive lipids especially arachidonic acid (AA) in response to microbial infections to inactivate them and upregulate the immune system.
Undurti N. Das
doaj   +1 more source

Molecular pathobiology of scleritis and its therapeutic implications [PDF]

International Journal of Ophthalmology, 2020
Scleritis and other autoimmune diseases are characterized by an imbalance in the levels of pro-inflammatory and anti-inflammatory molecules with the balance tilted more towards the former due to the failure of recognition of self.
Undurti N Das
doaj   +1 more source

Lipoxins as biomarkers of lupus and other inflammatory conditions

Lipids in Health and Disease, 2011
Inflammatory events persist in systemic lupus erythematosus (lupus) despite the use of anti-inflammatory (both steroidal and non-steroidal) and immunosuppressive drugs leading to delay in the healing/repair process and so tissue/organ damage continues ...
Das Undurti N
doaj   +1 more source

Obesity-Driven Deficiencies of Specialized Pro-resolving Mediators May Drive Adverse Outcomes During SARS-CoV-2 Infection

Frontiers in Immunology, 2020
Obesity is a major independent risk factor for increased morbidity and mortality upon infection with Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2), which is responsible for the current coronavirus disease pandemic (COVID-19).
Anandita Pal, Kymberly M. Gowdy, Kenneth J. Oestreich, Melinda Beck, Saame Raza Shaikh   +4 more
doaj   +1 more source