Results 1 to 10 of about 4,926 (194)
The Role of Resolvins, Protectins and Marensins in Non-Alcoholic Fatty Liver Disease (NAFLD)
Biomolecules, 2021 Increased triacylglycerols’ (TAG) synthesis, insulin resistance, and prolonged liver lipid storage might lead to the development of non-alcoholic fatty liver disease (NAFLD).
Dominika Maciejewska +2 more
exaly +4 more sources
Molecules, 2022 Marine organisms are an important source of natural products with unique and diverse chemical structures that may hold the key for the development of novel drugs.
Narcisa M Bandarra +2 more
exaly +4 more sources
Resolvins and Protectins in Inflammation Resolution [PDF]
Chemical Reviews, 2011 The critical role of inflammatory processes in health and disease has long been recognized,1 yet the detailed molecular mechanisms and biological events that regulate the progression and resolution of inflammation remain of interest. A number of recent investigations have provided strong evidence that the resolution of inflammation is not a passive ...
Charles N Serhan, Nicos A Petasis
exaly +4 more sources
Major Structure–Activity Relationships of Resolvins, Protectins, Maresins and Their Analogues
Future Medicinal Chemistry, 2022 Resolvins, protectins and maresins are a series of polyunsaturated fatty acid-derived molecules which play important roles in the resolution of inflammation. They are termed specialized proresolving mediators and facilitate a return to homeostasis following an inflammatory response.
Timothy P O'Sullivan
exaly +5 more sources
Frontiers in Immunology, 2013 Inflammation, in conjunction with leukocytes, plays a key role in most acute kidney injury (AKI). Non-resolving renal inflammation leads to fibrosis and chronic renal failure.
Song Hong
exaly +4 more sources
The biosynthetic pathways of the protectins
Prostaglandins and Other Lipid Mediators, 2023 Evidence for the biosynthetic pathways of the specialized pro-resolving mediator (SPM) protectin D1 (PD1) and its biochemical further local metabolism were presented during the 8th European Workshop on Lipid Mediators, organized June 29th-July 1st, 2022, in Stockholm, Sweden. Herein, we provide an extended and detailed discussion of these topics.
Trond Vidar Hansen
exaly +3 more sources
Protectins: Their biosynthesis, metabolism and structure-functions
Biochemical Pharmacology, 2022 Several lipoxygenase enzymes and cyclooxygenase-2 stereoselectively convert the polyunsaturated fatty acids arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid, and n-3 docosapentaenoic acid into numerous oxygenated products. Biosynthetic pathway studies have shown, during the resolution phase of acute inflammation, that distinct families of ...
Trond Vidar Hansen, Charles N Serhan
exaly +5 more sources
Macrophages: their role in immunity and their relationship with fatty acids in health and disease [PDF]
Frontiers in ImmunologyThe intricate interplay between macrophage biology and lipid metabolism has emerged as a critical determinant of metabolic homeostasis, disease progression and pathogenesis.
Mayte Rueda-Munguía +9 more
doaj +2 more sources
Resolvins and protectins: Natural pharmacophores for resolution biology [PDF]
Prostaglandins Leukotrienes and Essential Fatty Acids, 2010 Dietary ingestion of fish is associated with a reduced risk for many common human illnesses. Fish oils are enriched with n-3 polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid. Resolvins and protectins are newly discovered mediators that are enzymatically generated from these n-3 fatty acid precursors to orchestrate inflammation
Bruce D Levy
exaly +3 more sources
DHA- and EPA-derived resolvins, protectins, and maresins in airway inflammation [PDF]
European Journal of Pharmacology, 2016 Essential fatty acids can serve as important regulators of inflammation. A new window into mechanisms for the resolution of inflammation was opened with the identification and structural elucidation of mediators derived from these fatty acids with pro-resolving capacity.
Melody G Duvall, Bruce D Levy
exaly +3 more sources