Results 51 to 60 of about 3,920 (194)

Novel and emerging antimicrobial strategies in the management of oral infections

Periodontology 2000, EarlyView.
Abstract Background Antibiotics marked a pivotal turning point in human civilization, enhancing social interactions and extending human life expectancy. In addition to their success in treating systemic infectious diseases, they have significantly improved periodontal treatment outcomes as an adjunct therapy.
Ozge Unlu, Nil Yakar, Alpdogan Kantarci
wiley   +1 more source

Pharmacological effects of specialized pro-resolving mediators in sepsis-induced organ dysfunction: a narrative review

Frontiers in Immunology
Sepsis is a life-threatening syndrome of organ dysfunction, characterized by uncontrolled inflammatory response and immune dysregulation, often leading to multiple organ failure and even death.
Shujun Sun, Shujun Sun, Shujun Sun, Shujun Sun, Dong Yang, Dong Yang, Dong Yang, Jing Lv, Jing Lv, Jing Lv, Haifa Xia, Haifa Xia, Haifa Xia, Zhangyan Mao, Zhangyan Mao, Zhangyan Mao, Zhangyan Mao, Xiangdong Chen, Xiangdong Chen, Xiangdong Chen, Yafen Gao, Yafen Gao, Yafen Gao   +22 more
doaj   +1 more source

A defect in Δ⁶ and Δ⁵ desaturases may be a factor in the initiation and progression of insulin resistance, the metabolic syndrome and ischemic heart disease in South Asians

Lipids in Health and Disease, 2010
The high incidence of insulin resistance and the metabolic syndrome in South Asians remains unexplained. I propose that a defect in the activity of Δ6 and Δ5 desaturases and consequent low plasma and tissue concentrations of polyunsaturated fatty acids ...
Das Undurti N
doaj   +1 more source

Impact of systemic diseases on periodontal remodeling: Mechanisms, mediators, and clinical relevance

Periodontology 2000, EarlyView.
Abstract Background Periodontal remodeling is a continuous, adaptive process essential for maintaining the structural and functional integrity of periodontal tissues. While external factors such as bacterial biofilm, excessive forces, and poor oral hygiene are recognized triggers of periodontal pathologies, they do not fully explain their persistent ...
Michael Wolf, Ulrike Schulze‐Späte, Thomas Van Dyke, Stefan Wolfart, Thomas Dietrich, Alberto Ortiz, Zhuojun Wu, Joachim Jankowski   +7 more
wiley   +1 more source

Maresin 1 biosynthesis during platelet–neutrophil interactions is organ-protective [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance Neutrophil accumulation is fundamental to acute inflammation. In response to tissue injury, circulating neutrophil–platelet aggregates (N-PAs) form for secondary capture. Counterregulation of acute inflammatory processes by specialized proresolving mediators is essential to mitigate collateral injury to healthy bystander ...
Abdulnour, Raja-Elie, Dalli, Jesmond, Colby, Jennifer, Krishnamoorthy, Nandini, Timmons, Jack, Tan, Sook Hwa, Colas, Romain, Petasis, Nicos, Serhan, Charles, Levy, Bruce   +9 more
openaire   +4 more sources

Arachidonic acid and other unsaturated fatty acids and some of their metabolites function as endogenous antimicrobial molecules: A review

Journal of Advanced Research, 2018
Our body is endowed with several endogenous anti-microbial compounds such as interferon, cytokines, free radicals, etc. However, little attention has been paid to the possibility that lipids could function as antimicrobial compounds. In this short review,
Undurti N. Das
doaj   +1 more source

The DPA-derivative 11S, 17S-dihydroxy 7,9,13,15,19 (Z,E,Z,E,Z)-docosapentaenoic acid inhibits IL-6 production by inhibiting ROS production and ERK/NF-κB pathway in keratinocytes HaCaT stimulated with a fine dust PM10

Ecotoxicology and Environmental Safety, 2022
11 S, 17S-dihydroxy 7,9,13,15,19 (Z,E,Z,E,Z)-docosapentaenoic acid (DoPE) is a derivative of docosapentaenoic acid, a specialized pro-resolving mediator of inflammation such as lipoxins, resolvins, maresins, and protectins.
Myoung-Kwon Choi, Jinju Kim, Hyo-Min Park, Chae-Min Lim, Thu-Huyen Pham, Ha Youn Shin, Seong-Eun Kim, Deok-Kun Oh, Do-Young Yoon   +8 more
doaj   +1 more source

Specialized Pro-Resolving Lipid Mediators and Dietary Omega-3/6 Fatty Acids in Selected Inflammatory Skin Diseases: A Systematic Review. [PDF]

Antioxidants (Basel)
Specialized pro-resolving mediators (SPMs), including lipoxins, resolvins, protectins, and maresins, actively terminate inflammation and restore tissue homeostasis.
Biełach-Bazyluk A, Jakubowicz-Zalewska O, Myśliwiec H, Flisiak I.   +3 more
europepmc   +2 more sources

Histiocytes: Multifaceted Regulators of Health and Disease

Veterinary Clinical Pathology, EarlyView.
ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley   +1 more source

Microglia in Pain: Detrimental and protective roles in pathogenesis and resolution of pain

Neuron, 2018
The previous decade has seen a rapid increase in microglial studies on pain, with a unique focus on microgliosis in the spinal cord after nerve injury and neuropathic pain.
Gang Chen, Yu-Qiu Zhang, Y. Qadri, C. Serhan, R. Ji   +4 more
semanticscholar   +1 more source