Results 61 to 70 of about 3,395 (149)

Capybara Oil‐Based Nanoemulsion Attenuates Obesity‐Induced Renal Injury Through Modulation of Inflammation, Oxidative Stress, and Fibrosis in Mice

Cell Biochemistry and Function, Volume 44, Issue 10, October 2026.
ABSTRACT Obesity is a multifactorial disorder associated with systemic metabolic alterations and increased risk of renal injury, largely driven by chronic inflammation and oxidative stress. Bioactive lipids, particularly polyunsaturated fatty acids, have been shown to exert protective effects; however, their instability and susceptibility to oxidation ...
Priscila G. Pereira, Luciana L. Alves, Bianca T. Ciambarella, Stela R. Ferrarini, Ana Lúcia R. Nascimento, Cherley B. V. Andrade, Alan Cesar N. Moraes, Andressa Bernardi, Fernanda V. Guimarães, Miguel P. Campos, Denia M. S. Valladão, Letícia Cruz, Jemima F. R. da Silva, Kíssila Rabelo, Jorge J. de Carvalho   +14 more
wiley   +1 more source

Unified Nexus of Macrophages and Maresins in Cardiac Reparative Mechanisms

, 2018
Macrophages are immune-sensing big eater phagocytic cells responsible for an innate, adaptive, and regenerative response. Aftermyocardial infarction,macrophages predominantly clear the deceased cardiomyocyte apoptotic or necrotic neutrophils to develop
Halade, Ganesh V., Ganesh V. Halade, Jadapalli, Jeevan Kumar, Jeevan Kumar Jadapalli   +3 more
core   +1 more source

Alveolar Macrophages: Development, Respiratory Homeostasis, Signal Pathways, Diseases, and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
Alveolar macrophages: development, respiratory homeostasis, signal pathways, diseases, and therapeutic opportunities: During embryonic development, fetal progenitors migrate to the developing lungs via a CX3CR1‐dependent mechanism to establish the TrAM pool.
Sihan Yang, Ruomeng Li, Chuanjiang Yu, Jing Li, Xikun Zhou   +4 more
wiley   +1 more source

Tirzepatide and SGLT2 Inhibitors for Heart Failure With Preserved Ejection Fraction and Obesity: Entering a New Cardiometabolic Therapeutic Era

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
Tirzepatide and SGLT2 inhibitors act through distinct but complementary mechanisms in obesity‐related HFpEF: tirzepatide targets adiposity, inflammation, and insulin resistance, while SGLT2 inhibitors improve decongestion, myocardial energetics, and cardiac remodeling.
Zakariye Isak Mohamed, Abdinasir Adam Shidane, Abdullahi Mohamud Abdiasis, Mohamed Hassan Hussein, Ayaanle Osman Ibrahim, Anas Ali Abdi, Kowthar Ismail Hashi, Mohamed Abdullahi Mohamud, Ali Jimale Mohamed   +8 more
wiley   +1 more source

Plasticity of Leukocytic Exudates in Resolving Acute Inflammation Is Regulated by MicroRNA and Proresolving Mediators [PDF]

, 2013
SummaryThe magnitude and duration of acute inflammation are controlled by active resolution programs involving specialized proresolving mediators (SPMs; resolvins and maresins) and microRNAs (miRNAs).
Quintana, Carolina, Chiang, Nan, Dalli, Jesmond, Carolina Quintana, Charles N. Serhan, Baron, Rebecca M., Jesmond Dalli, Serhan, Charles N., Yongsheng Li, Li, Yongsheng, Rebecca M. Baron, Nan Chiang   +11 more
core   +1 more source

Roles, Actions, and Therapeutic Potential of Specialized Pro-resolving Lipid Mediators for the Treatment of Inflammation in Cystic Fibrosis

Frontiers in Pharmacology, 2019
Non-resolving inflammation is the main mechanism of morbidity and mortality among patients suffering from cystic fibrosis (CF), the most common life-threatening human genetic disease.
Antonio Recchiuti, Antonio Recchiuti, Domenico Mattoscio, Domenico Mattoscio, Elisa Isopi, Elisa Isopi   +5 more
doaj   +1 more source

Molecular Pharmacology of Inflammation Resolution in Atherosclerosis

, 2022
Atherosclerosis is one of the most important problems of modern medicine as it is the leading cause of hospitalizations, disability, and mortality. The key role in the development and progression of atherosclerosis is the imbalance between the activation
Kotlyarova, Anna, Anna Kotlyarova, Stanislav Kotlyarov, Kotlyarov, Stanislav   +3 more
core   +1 more source

Identification of Epigenetic Regulator‐Associated Genes in Keloid Disease Through Integrated Bulk and Single‐Cell Transcriptomics With RT‐qPCR Validation

The FASEB Journal, Volume 40, Issue 16, 31 August 2026.
Step I: Screened HR/SMYD4 as key keloid epigenetic genes via bulk/scRNA‐seq and machine learning. Step II: Built a high‐performance nomogram (AUC = 0.988). Step III: Conducted multi‐omics analyses. Step IV: Experimentally verified their differential expression and pathogenic roles.
Yifei Wang, Shuqian Dou, Mingkun Dai, Guoxun Yang, Wenjun Liu   +4 more
wiley   +1 more source

Fatty Acid Signatures as Nutritional Indices: Molecular Gateways to Health, Aging, and Functional Food Innovation

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Systems framework linking dietary fatty acids with the functional lipidome, health, and precision nutrition. Dietary fatty acids from plant‐based, marine, and animal sources undergo absorption, endogenous desaturation and elongation, oxidation, and tissue‐specific incorporation and remodeling, generating individualized FA signatures.
Mohammad Nazrul Islam Bhuiyan, Md. Selim Reza, Farzana Mim   +2 more
wiley   +1 more source

Omega Fatty Acids in Hair Loss Disorders: A Scoping Review of Preclinical and Clinical Evidence [PDF]

J Cosmet Dermatol
ABSTRACT Background Omega fatty acids, including polyunsaturated omega‐3 and omega‐6 fatty acids (PUFAs) and monounsaturated omega‐9 fatty acids, regulate inflammation, cellular signaling, and tissue homeostasis, and may influence hair follicle biology and hair growth.
Abdul‐Rahman N, Wang J, Motlak M, Guiltarte G, Padmanabhan R, Lee E, Choudhary S.   +6 more
europepmc   +2 more sources