Results 41 to 50 of about 3,018 (169)

Cysteinyl maresins regulate the prophlogistic lung actions of cysteinyl leukotrienes [PDF]

Journal of Allergy and Clinical Immunology, 2020
Cysteinyl leukotrienes (CysLTs) are potent prophlogistic mediators in asthmatic patients; however, inhibition of CysLT receptor 1 is not a consistently effective treatment, suggesting additional regulatory mechanisms. Other cysteinyl-containing lipid mediators (LMs) derived from docosahexaenoic acid, namely maresin conjugates in tissue regeneration ...
Bruce D. Levy, Raja-Elie E. Abdulnour, Alexander Tavares, Thayse R. Brüggemann, Paul C. Norris, Yan Bai, Xingbin Ai, Charles N. Serhan   +7 more
openaire   +2 more sources

Maresin Biosynthesis and Identification of Maresin 2, a New Anti-Inflammatory and Pro-Resolving Mediator from Human Macrophages

PLoS ONE, 2014
Maresins are a new family of anti-inflammatory and pro-resolving lipid mediators biosynthesized from docosahexaenoic acid (DHA) by macrophages. Here we identified a novel pro-resolving product, 13R,14S-dihydroxy-docosahexaenoic acid (13R,14S-diHDHA), produced by human macrophages.
Deng, Bin, Arnardottir, Hildur H., Dalli, Jesmond P, Serhan, Charles, Wang, Chin-Wei, Li, Yongsheng, Cheng, Chien-Yee Cindy   +6 more
openaire   +6 more sources

Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions [PDF]

Journal of Experimental Medicine, 2008
The endogenous cellular and molecular mechanisms that control acute inflammation and its resolution are of wide interest. Using self-resolving inflammatory exudates and lipidomics, we have identified a new pathway involving biosynthesis of potent antiinflammatory and proresolving mediators from the essential fatty acid docosahexaenoic acid (DHA) by ...
Serhan, Charles N., Yang, Rong, Martinod, Kimberly, Kasuga, Kie, Pillai, Padmini S., Porter, Timothy F., Oh, Sungwhan F., Spite, Matthew   +7 more
openaire   +4 more sources

Ageing: Is there a role for arachidonic acid and other bioactive lipids? A review

Journal of Advanced Research, 2018
Ageing is inevitable. Recent studies suggest that it could be delayed. Low-grade systemic inflammation is seen in type 2 diabetes mellitus, hypertension and endothelial dysfunction that are common with increasing age.
Undurti N. Das
doaj   +1 more source

Maresins: anti-inflammatory pro-resolving mediators with therapeutic potential.

European review for medical and pharmacological sciences, 2020
Although inflammation is protective of the body, uncontrolled acute inflammatory reactions may inflict tissue damage and lead to chronic inflammation. There is a fast-growing research interest in mechanisms that mediate regression of inflammation and actions of anti-inflammatory factors.
Li, Q.-F., Hao, H., Tu, W.-S., Guo, N., Zhou, X.-Y.   +4 more
openaire   +2 more sources

Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance We recently uncovered a family of macrophage-derived molecules, coined maresin conjugates in tissue regeneration, that regulate the system’s ability to clear bacteria as well as repair and regenerate damaged tissues. In the present study, we identified enzymes involved in the formation of these potent molecules in human ...
Dalli, Jesmond, Vlasakov, Iliyan, Riley, Ian R., Rodriguez, Ana R., Spur, Bernd W., Petasis, Nicos A., Chiang, Nan, Serhan, Charles N.   +7 more
openaire   +4 more sources

Serum Maresin-1 and Resolvin-D1 Levels as Non-Invasive Biomarkers for Monitoring Disease Activity in Ulcerative Colitis

Diagnostics
Background: Specialized pro-resolving lipid mediators (SPMs), such as maresins and resolvins, play a key role in resolving inflammation and repairing tissues.
Selim Demirci, Semih Sezer
doaj   +1 more source

Can vagus nerve stimulation halt or ameliorate rheumatoid arthritis and lupus?

Lipids in Health and Disease, 2011
Acetylcholine, the principal vagus neurotransmitter, inhibits inflammation by suppressing the production of pro-inflammatory cytokines through a mechanism dependent on the α7 nicotinic acetylcholine receptor subunit (alpha7nAChR) that explains why vagus ...
Das Undurti N
doaj   +1 more source

Decreased Plasma Maresin 1 Concentration Is Associated with Diabetic Foot Ulcer [PDF]

Mediators of Inflammation, 2020
Aims. To assess the maresin 1 (MaR1) contents in type 2 diabetic patients with or without diabetic foot ulcer and to analyze the association of MaR1 concentrations with several metabolism-related parameters. Methods. Plasma MaR1 concentrations were analyzed in 96 subjects with normal glucose tolerant (NC, n=43), type 2 diabetes (T2DM, n=40), or ...
Tian Miao, Bangliang Huang, Niexia He, Lihua Sun, Guangsheng Du, Xiaoli Gong, Yong Xu, Yi Zheng, Hongting Zheng, Hua Qu   +9 more
openaire   +3 more sources

Beneficial role of bioactive lipids in the pathobiology, prevention, and management of HBV, HCV and alcoholic hepatitis, NAFLD, and liver cirrhosis: A review

Journal of Advanced Research, 2019
It has been suggested that hepatitis B virus (HBV)- and hepatitis C virus (HCV)-induced hepatic damage and cirrhosis and associated hypoalbuminemia, non-alcoholic fatty liver disease (NAFLD), and alcoholic fatty liver disease (AFLD) are due to an ...
Undurti N. Das
doaj   +1 more source