Results 41 to 50 of about 3,395 (149)

SPMs exert anti-inflammatory and pro-resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor. [PDF]

Proc Natl Acad Sci U S A
Inflammation is a protective response to pathogens and injury. To be effective it needs to be resolved by endogenous mechanisms in order to avoid prolonged and excessive inflammation, which can become chronic.
Alnouri MW, Roquid KA, Bonnavion R, Cho H, Heering J, Kwon J, Jäger Y, Wang S, Günther S, Wettschureck N, Geisslinger G, Gurke R, Müller CE, Proschak E, Offermanns S.   +14 more
europepmc   +2 more sources

Integrative Approaches in Cardiovascular Disease: The Role of Nutraceuticals in Heart Failure, Atrial Fibrillation, and Related Conditions

Phytotherapy Research, EarlyView.
Schematic representation of the shared pathophysiological mechanisms underlying heart failure (HF) and atrial fibrillation (AF), including inflammation, oxidative stress, endothelial dysfunction, and fibrosis. The figure highlights the clinical and mechanistic convergence of conventional pharmacological therapies and selected nutraceuticals in ...
Laura Beatrice Mattioli, Ivan Corazza, Roberta Budriesi, Luca Camarda, Maria Carelli, Alberto Spadotto, Igor Diemberger   +6 more
wiley   +1 more source

Pro-Resolving Maresins in Inflammation: New Pathway and Mechanisms With Oral Pathogens

, 2015
Objectives The aim of this thesis was to study the biosynthesis of Maresin 1 (MaR1) in human macrophage and to investigate the potential defect of this pathway in patients with localized aggressive periodontitis as well as the role of MaR1 in regulating ...
Wang, Chin-Wei
core   +5 more sources

Beneficial role of bioactive lipids in the pathobiology, prevention, and management of HBV, HCV and alcoholic hepatitis, NAFLD, and liver cirrhosis: A review

Journal of Advanced Research, 2019
It has been suggested that hepatitis B virus (HBV)- and hepatitis C virus (HCV)-induced hepatic damage and cirrhosis and associated hypoalbuminemia, non-alcoholic fatty liver disease (NAFLD), and alcoholic fatty liver disease (AFLD) are due to an ...
Undurti N. Das
doaj   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

Clinical improvement and scalp microbiome restructuring following a 28‐day piroctone olamine shampoo intervention

International Journal of Cosmetic Science, EarlyView.
A 28‐day clinical study in 41 individuals with oily dandruff showed that a piroctone olamine shampoo improved clinical symptoms while selectively reshaping the scalp bacterial and fungal microbiome toward a less dysbiotic profile. Abstract Objective To evaluate the clinical efficacy of a piroctone olamine–containing shampoo in individuals with oily ...
Spyridon Markos, Lina Praefke, Yiannis Kapetanstatakis, Michail Tsanakas, Evangelos Beletsiotis   +4 more
wiley   +1 more source

N−3 fatty acid supplementation in asthma management: A systematic review and meta‐analysis

, 2021
Laboratory and epidemiological evidence suggests that n−3 fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are beneficial in asthma prevention and possibly treatment through their anti- inflammatory effect.1 The ...
André Moreira, Fan, HY, Han‐Pin Kuo, Hsien‐Yu Fan, Maria Michelle Papamichael, Yu‐Hsin Wang, Kuo, HP, Yang‐Ching Chen, Wang, YH, Papamichael, MM, Moreira, A, Shih‐Yi Huang, Huang, SY, Chen, YC   +13 more
core   +1 more source

LGR6 couples maresin 1 signaling to glycolytic flux and protein lactylation for the rescue of diabetic cardiomyopathy

Journal of Diabetes Investigation, EarlyView.
MaR1 activates LGR6‐AMPK signaling to restore metabolic flexibility in diabetic hearts. Glycolytic recovery replenishes intracellular lactate to rescue protective protein lysine lactylation, which reactivates PINK1/Parkin‐mediated mitophagy to eliminate damaged mitochondria.
Bin Feng, Chao Chen, Lin Chen, Yuqiong Chen, Wenjun Mao, Peiran Yu, Hao Yu, Bimin Shi, Nannan Zhang   +8 more
wiley   +1 more source

The DPA-derivative 11S, 17S-dihydroxy 7,9,13,15,19 (Z,E,Z,E,Z)-docosapentaenoic acid inhibits IL-6 production by inhibiting ROS production and ERK/NF-κB pathway in keratinocytes HaCaT stimulated with a fine dust PM10

Ecotoxicology and Environmental Safety, 2022
11 S, 17S-dihydroxy 7,9,13,15,19 (Z,E,Z,E,Z)-docosapentaenoic acid (DoPE) is a derivative of docosapentaenoic acid, a specialized pro-resolving mediator of inflammation such as lipoxins, resolvins, maresins, and protectins.
Myoung-Kwon Choi, Jinju Kim, Hyo-Min Park, Chae-Min Lim, Thu-Huyen Pham, Ha Youn Shin, Seong-Eun Kim, Deok-Kun Oh, Do-Young Yoon   +8 more
doaj   +1 more source

Serum Maresin-1 and Resolvin-D1 Levels as Non-Invasive Biomarkers for Monitoring Disease Activity in Ulcerative Colitis

Diagnostics
Background: Specialized pro-resolving lipid mediators (SPMs), such as maresins and resolvins, play a key role in resolving inflammation and repairing tissues.
Selim Demirci, Semih Sezer
doaj   +1 more source