Results 161 to 170 of about 93,050 (197)

Carrier-mediated transport of lipoxin A4 in human neutrophils

American Journal of Physiology-Cell Physiology, 1994
Lipoxins and other eicosanoids display potent and selective biological effects on leukocytes. In this study, we utilized radiolabeled lipoxin A4 ([3H]LXA4) to investigate whether carrier-mediated transport of LXA4 might occur in human neutrophils. At a concentration of 5 nM, uptake of [3H]LXA4, above that due to specific binding to receptors, amounted
L, Simchowitz, S, Fiore, C N, Serhan
openaire   +2 more sources

Effects of Lipoxin A4 on antimicrobial actions of neutrophils in sepsis

Prostaglandins, Leukotrienes and Essential Fatty Acids, 2015
In sepsis, hyperactivation of neutrophils can lead to tissue injury. Later, neutrophil dysregulation with reduced levels of migration, decreased apoptosis and inadequate phagocytosis may impair the host׳s ability to clear infection. Lipoxin A4 (LXA4) is a pro-resolution lipid mediator which reduces neutrophil migration and inflammatory mediator ...
B, Wu, J, Walker, B, Spur, A, Rodriguez, K, Yin   +4 more
openaire   +2 more sources

Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent

Nature Medicine, 2006
Control of inflammation is crucial to prevent damage to the host during infection. Lipoxins and aspirin-triggered lipoxins are crucial modulators of proinflammatory responses; however, their intracellular mechanisms have not been completely elucidated.
Fabiana S, Machado, James E, Johndrow, Lisia, Esper, Alexandra, Dias, Andre, Bafica, Charles N, Serhan, Julio, Aliberti   +6 more
openaire   +2 more sources

Role of the lipoxin A4 receptor in inflammation

2010
Der Lipoxin A4 Rezeptor (ALXR) wird von nahezu allen Leukozyten exprimiert und erfüllt eine wichtige Funktion in der Wirtsabwehr und in entzündlichen Erkrankungen wie rheumatoide Arthritis und Asthma. Der Rezeptor bindet strukturell unterschiedliche agonistische Liganden. Dazu gehören Peptide und Lipidmediatoren, welche vor allem die Chemotaxis und die
openaire   +1 more source

Lipoxin A4

Lipidomics Gateway, 2011
openaire   +2 more sources

Lipoxin A4 on neutrophil reprogramming in bronchiectasis

2018
INTRODUCTION Bronchiectasis is a common chronic debilitating respiratory condition. Patients suffer daily cough, excess sputum production and recurrent chest infections because of inflamed and permanently damaged airways. The pathogenesis of bronchiectasis is poorly understood.
openaire   +1 more source

Pharmacodynamics of lipoxin A4 in airway smooth muscle

Agents and Actions, 1989
S E, Dahlén, C A, Veale, S E, Webber, B E, Marron, K C, Nicolaou, C N, Serhan   +5 more
openaire   +2 more sources

Changes of lipoxin levels during pregnancy and the monthly-cycle, condition the normal course of pregnancy or pathology

Inflammation Research, 2020
Malgorzata Szczuko, Natalia Komorniak, Maciej Zietek   +2 more
exaly  

Lipoxin alleviates oxidative stress: a state-of-the-art review

Inflammation Research, 2022
Chong-Ge You
exaly  

Lipoxin A4 activates ALX/FPR2 to attenuate inflammation in keratitis

International Immunopharmacology, 2021
Yingxue Zhang, Guiqiu Zhao, Xiaojia Zhu
exaly