Results 161 to 170 of about 5,641 (199)
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Total synthesis of novel geometric isomers of lipoxin A4 and lipoxin B4
The Journal of Organic Chemistry, 1989La synthese stereoselective des composes du titre utilise des reactions basees sur le couplage Pd(0)-Cu(I)
K. C. Nicolaou +4 more
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Inhibition of leukotriene B4 in neutrophils by lipoxins A4 and B4
Agents and Actions, 1991Lipoxins are derived from the oxygenation products of arachidonic acid in human leukocytes. They have exhibited selective biological effects different from those of other eicosanoids. We have examined the effect of lipoxin A4 and B4 (LXA4, LXB4) on the production of leukotriene B4 (LTB4) in human neutrophils. Cultured human polymorphonuclear leukocytes
P, Conti +4 more
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Lipoxin A4: The Double-edge Sword in Mice Pregnancy
American Journal of Reproductive Immunology, 2014To evaluate the role for LXA4 in the pregnancy.We detected the changes of LXA4 and LXA4 biosynthetic enzymes in the mice's pregnancy, blocked LXA4 signaling pathway, managed LXA4 level, and treated LPS-induced mouse abortion model to systematically determine how LXA4 impact pregnancy.The concentrations of LXA4 in serum and uterus were lowest on Days 4 ...
Zhangye, Xu +5 more
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Effects of Lipoxin A4 on antimicrobial actions of neutrophils in sepsis
Prostaglandins, Leukotrienes and Essential Fatty Acids, 2015In sepsis, hyperactivation of neutrophils can lead to tissue injury. Later, neutrophil dysregulation with reduced levels of migration, decreased apoptosis and inadequate phagocytosis may impair the host׳s ability to clear infection. Lipoxin A4 (LXA4) is a pro-resolution lipid mediator which reduces neutrophil migration and inflammatory mediator ...
B, Wu +4 more
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1999
Lipoxins (LX) are trihydroxytetraene-containing eicosanoids that are generated within vascular lumen by platelet-leukocyte interactions and at mucosal surfaces by leukocyte-epithelial cell interactions. During these cell-cell interactions, transcellular biosynthetic pathways are used as major routes, and thus, in humans, LX are formed in vivo during ...
C N, Serhan, T, Takano, J F, Maddox
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Lipoxins (LX) are trihydroxytetraene-containing eicosanoids that are generated within vascular lumen by platelet-leukocyte interactions and at mucosal surfaces by leukocyte-epithelial cell interactions. During these cell-cell interactions, transcellular biosynthetic pathways are used as major routes, and thus, in humans, LX are formed in vivo during ...
C N, Serhan, T, Takano, J F, Maddox
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Carrier-mediated transport of lipoxin A4 in human neutrophils
American Journal of Physiology-Cell Physiology, 1994Lipoxins and other eicosanoids display potent and selective biological effects on leukocytes. In this study, we utilized radiolabeled lipoxin A4 ([3H]LXA4) to investigate whether carrier-mediated transport of LXA4 might occur in human neutrophils. At a concentration of 5 nM, uptake of [3H]LXA4, above that due to specific binding to receptors, amounted
L, Simchowitz, S, Fiore, C N, Serhan
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The Effects of Lipoxin A4 on Airway Responses in Asthmatic Subjects
American Review of Respiratory Disease, 1992Abstract This study was performed to determine whether lipoxin A4 (LXA4) inhalation in asthmatic subjects has an effect on airways response. Eight subjects (six asthmatic, two normal) attended for bronchial inhalation challenge with LXA4.
P E, Christie, B W, Spur, T H, Lee
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Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent
Nature Medicine, 2006Control of inflammation is crucial to prevent damage to the host during infection. Lipoxins and aspirin-triggered lipoxins are crucial modulators of proinflammatory responses; however, their intracellular mechanisms have not been completely elucidated.
Fabiana S, Machado +6 more
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Role of the lipoxin A4 receptor in inflammation
2010Der Lipoxin A4 Rezeptor (ALXR) wird von nahezu allen Leukozyten exprimiert und erfüllt eine wichtige Funktion in der Wirtsabwehr und in entzündlichen Erkrankungen wie rheumatoide Arthritis und Asthma. Der Rezeptor bindet strukturell unterschiedliche agonistische Liganden. Dazu gehören Peptide und Lipidmediatoren, welche vor allem die Chemotaxis und die
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