Results 271 to 280 of about 46,425 (297)

Eicosatetraenehydroxamates: inhibitors of 5-lipoxygenase

Tetrahedron Letters, 1985
Abstract The syntheses of 5-hydroxamyl and 5-hydroxamylmethyl-6,8,11,14,-eicosatetraenoic acids ( 3 and 4 ), which possess potent 5-lipoxygenase inhibitory activity, are described.
F.A.J. Kerdesky, J.H. Holms, S.P. Schmidt, R.O. Dyer, G.W. Carter   +4 more
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Inhibitors of 15-Lipoxygenase from Orange Peel

Journal of Agricultural and Food Chemistry, 2000
A series of polymethoxylated flavonoids has been isolated from orange peel, and their inhibitory activity toward soybean 15-lipoxygenase was determined. The strongest inhibition was shown by 3,5,6,7,3',4'-hexamethoxyflavone (IC(50) = 49 +/- 5 microM). Sinensetin, nobiletin, tangeretin, tetramethylscutellarein, and 3,5, 6,7,8,3',4'-heptamethoxyflavone ...
K E, Malterud, K M, Rydland
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5-Lipoxygenase inhibitors: a patent evaluation (WO2011161615)

Expert Opinion on Therapeutic Patents, 2012
1,5-Diarylpyrazoles are privileged scaffolds used for the development of COX-2 (cyclooxygenase 2) selective inhibitors (coxibs). Derivatives of 1,5-diarylpyrazoles are currently being used as 5-lipoxygenase (5-LO) inhibitors for the treatment of respiratory diseases, inflammatory and autoimmune disorders.
Estel la, Buscató, Ewgenij, Proschak
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[Inhibitors of 5-lipoxygenase].

Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 2002
Leukotrienes are powerful mediators of inflammation processes. Possibilities of their biosynthesis inhibition have been intensively studied during recent two decades aiming to develop new methods of therapy of various inflammatory diseases, particularly asthma. Biosynthesis of all leukotrienes is dependent on the production of the key intermediate LTA4.
M, Gápovský, M, Remko
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Novel bishydroxamic acids as 5-lipoxygenase inhibitors

Bioorganic & Medicinal Chemistry, 1994
Two series of novel bishydroxamic acids 2 and 3 (types A and B) were synthesized and tested for inhibition of 5-lipoxygenase from rat basophile leukemia (RBL) cells. Both series were potent inhibitors of the isolated enzyme but only the type B reverse hydroxamic acids possessed significant oral activity. The most potent compound, orally, was 3a, [IC50 =
K A, Ohemeng, V N, Nguyen, C F, Schwender, M, Singer, M, Steber, J, Ansell, W, Hageman   +6 more
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Arachidonate 5-lipoxygenase and its new inhibitors

Journal of Allergy and Clinical Immunology, 1984
The 5-lipoxygenases of guinea pig peritoneal polymorphonuclear leukocytes and of rat basophilic leukemia cells have been solubilized, purified partially by affinity chromatography, and shown to convert arachidonic acid principally to 5-hydroperoxy-6,8,11,14- eicosatetraenoic acid.
S, Yamamoto, T, Yoshimoto, M, Furukawa, T, Horie, S, Watanabe-Kohno   +4 more
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Inhibitors of platelet lipoxygenase from Ponkan fruit

Phytochemistry, 2001
An activity-guided separation for inhibitors of rat platelet 12-lipoxygenase led to the isolation of two compounds, 4-O-feruloyl-5-O-caffeoylquinic acid (IC50; 5.5 microM) and methyl 4-O-feruloyl-5-O-caffeoylquinate (IC50; 1.9 microM) from the peel of Ponkan fruit (Citrus reticulata).
Y, Nogata, K, Sekiya, H, Ohta, K, Kusumoto, T, Ishizu   +4 more
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Lipoxygenase inhibitors prevent urological cancer cell growth

International Journal of Molecular Medicine, 2004
Recent studies have demonstrated that lipoxygenase (LOX) inhibitor induces growth arrest of cancer cells through apoptosis. In this study, we examined the effects of LOX inhibitors on cell proliferation in renal cell carcinoma (RCC), bladder tumor (BT), and prostate cancer (PC) cell lines. We investigated the inhibitory effect of LOX inhibitors, 5-, 12-
Masahide, Matsuyama, Rikio, Yoshimura, Kenji, Tsuchida, Yoshiaki, Takemoto, Yoshihiro, Segawa, Toshiaki, Shinnka, Yutaka, Kawahito, Hajime, Sano, Tatsuya, Nakatani   +8 more
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Flavonoids: Potent inhibitors of arachidonate 5-lipoxygenase

Biochemical and Biophysical Research Communications, 1983
Various flavonoids were found to be relatively selective inhibitors of arachidonate 5-lipoxygenase which initiates the biosynthesis of leukotrienes with the activity of slow reacting substance of anaphylaxis. Cirsiliol (3',4',5-trihydroxy-6,7-dimethoxyflavone) was most potent, and the enzyme partially purified from rat basophilic leukemia cells was ...
T, Yoshimoto, M, Furukawa, S, Yamamoto, T, Horie, S, Watanabe-Kohno   +4 more
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Comparative Biochemistry of Lipoxygenase Inhibitors

1985
This chapter describes some studies on the mechanism of 5-lipoxygenase regulation and inhibition and then presents an overview of lipoxygenase inhibitors that are active against intact-cell, broken-cell, and purifed enzymes from a variety of sources.
Robert W. Egan, Paul H. Gale
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