Results 1 to 10 of about 16,310 (221)

Diminished arachidonate 5-lipoxygenase perturbs phase separation and transcriptional response of Runx2 to reverse pathological ventricular remodelingResearch in context [PDF]

EBioMedicine, 2022
Summary: Background: Arachidonate 5-lipoxygenase (Alox5) belongs to a class of nonheme iron-containing dioxygenases involved in the catalysis of leukotriene biosynthesis.
Saiyang Xie, Mengya Chen, Wenxi Fang, Shiqiang Liu, Qingqing Wu, Chen Liu, Yun Xing, Wenke Shi, Man Xu, Min Zhang, Si Chen, Xiaofeng Zeng, Shasha Wang, Wei Deng, Qizhu Tang   +14 more
doaj   +2 more sources

Computational prediction of the pathogenic variants of arachidonate 5-lipoxygenase activating protein using Molecular Dynamics simulation. [PDF]

PLoS ONE
The arachidonate 5-lipoxygenase activating protein (ALOX5AP) regulates leukotrienes (LTs) synthesis. LTs are involved in inflammation which is implicated in cardiovascular diseases (CVDs) and stroke.
Mohamed E Elnageeb, Imadeldin Elfaki, Gad Allah Modawe, Abdelrahman Osman Elfaki, Othman R Alzahrani, Hytham A Abuagla, Hayam A Alwabsi, Adel I Alalawy, Mohammad Rehan Ajmal, Elsiddig Idriss Mohamed, Hussein Eledum, Syed Khalid Mustafa, Elham M Alhathli   +12 more
doaj   +3 more sources

Parent-determined oral montelukast therapy for preschool wheeze with stratification for arachidonate 5-lipoxygenase (ALOX5) promoter genotype: a multicentre, randomised, placebo-controlled trial

Efficacy and Mechanism Evaluation, 2015
Background: The clinical effectiveness of intermittent montelukast for wheeze in young children is unclear. Previous work has been equivocal. Variation in copy numbers of the specificity protein 1-binding motif in the arachidonate 5-lipoxygenase (ALOX5 ...
Chinedu Nwokoro, Hitesh Pandya, Stephen Turner, Sandra Eldridge, Christopher J Griffiths, Tom Vulliamy, David Price, Marek Sanak, John W Holloway, Rossa Brugha, Lee Koh, Iain Dickson, Clare Rutterford, Jonathan Grigg   +13 more
doaj   +2 more sources

Causal Pathways Linking Gut Microbiota, Serum Metabolites, and Meningioma Risk: A Mendelian Randomization Analysis. [PDF]

Brain Behav
This Mendelian randomization analysis elucidates causal pathways linking gut microbiota and serum metabolites to meningioma. We identified specific risk factors and found that arachidonic acid potentially mediates the effect of CAG−873 sp001701165 on meningioma risk.
Gong X, Zhang J, He M, Zhang X, Wang K, Yang Y, Zhao Q, Zhao X, Zou W.   +8 more
europepmc   +2 more sources

Irisin regulates lipid metabolism and ferroptosis in ovarian cancer cells by modulating the ALOX5-5-HETE-PD-L1 axis [PDF]

Scientific Reports
This study investigates the role of arachidonate 5-lipoxygenase (ALOX5) in upregulating programmed death-ligand 1 (PD-L1) expression via its metabolite 5-hydroxyeicosatetraenoic acid (5-HETE) in ovarian cancer cells, and explores the effects on lipid ...
Huichun Cai, Caiyun Huang, Zhenwei Zhang
doaj   +2 more sources

Chilling injury mechanism in the immature oocytes of zebrafish (Danio rerio) [PDF]

The Journal of Reproduction and Development
Immature zebrafish oocytes are sensitive to chilling, and their survival is markedly reduced by exposure to 0°C. In the present study, we investigated the involvement of cold-sensitive channels and lipid mediators in chilling injury in immature zebrafish ...
Yanuar ACHADRI, Shino SONODA, Saki OKUBO, Kazutsugu MATSUKAWA, Keisuke EDASHIGE   +4 more
doaj   +2 more sources

Ipriflavone From Aquilaria malaccensis Lam. Exosome‐Like Nanoparticles Targets Prolyl Hydroxylase Domain Protein 2 (PHD2) to Enhance Hypoxia‐Inducible Factor‐α (HIF‐α) Hydroxylation Thereby Alleviating Hypoxia‐Induced Gastrointestinal Mucosal Ferroptosis

MedComm
The major challenge in the clinical treatment of gastrointestinal mucosal injury caused by high‐altitude hypoxic environments lies in its unclear underlying mechanisms.
Dezhi Wang, Xingchen Liao, Yilin Wang, Xuexin Wang, Heng Zhang, Jie Zeng, Mingjie Zhang, Xin Wang, Fangli Ren, Yinyin Wang, Meng Li, Wenchen Wang, Qing Lin, Lingyun Gu, Zhijie Chang, Jianqiu Sheng   +15 more
doaj   +2 more sources

ALOX15‐Derived Oxylipins Attenuate Macrophage Inflammatory Signaling Via a Gαq–PLC–PKC Pathway [PDF]

FASEB J
ALOX15 expression and its downstream oxylipins, including 12‐HETE and 13‐HODE, are induced in intestinal epithelial and lamina propria immune cells during the early and middle phases of experimental colitis. These endogenous lipid mediators suppress lipopolysaccharide‐induced TNF‐α and IL‐6 production in macrophages without affecting cell viability ...
Hilman A, Ishii Y, Wijatniko B, Rini D, Suzuki T.   +4 more
europepmc   +2 more sources

Prediction of pEC50(M) and molecular docking study for the selective inhibition of arachidonate 5-lipoxygenase [PDF]

The Ukrainian Biochemical Journal, 2021
Arachidonate 5-lipoxygenase (ALOX5) is considered a prime target for drug discovery in the area of liver fibrosis, rheumatoid arthritis, atherosclerosis, cancer and asthma.
N. R. Das, P. G. R. Achary
doaj   +1 more source

Role of the route of leukotrienes in an experimental model of oral mucositis induced by 5-fluorouracil [PDF]

Acta Cirúrgica Brasileira, 2017
Purpose: To investigate the participation of cysteinyl leukotrienes in the pathophysiology of oral mucositis. Methods: Oral mucositis was induced in hamsters using 5-fluorouracil (5-FU; 60 and 40 mg/kg; i.p., on days 1 and 2, respectively, and with ...
Viviane Carvalho da Silva, Renata Ferreira de Carvalho Leitão, Gerly Anne de Castro Brito, Conceição da Silva Martins, Gildenio Estevam Freire, Karoline Saboia Aragão, Carlos Wagner de Souza Wanderley, Marcos Rabelo de Freitas   +7 more
doaj   +2 more sources