Results 41 to 50 of about 16,348 (221)

Inhibition of arachidonate 5-lipoxygenase by phenolic compounds.

Chemical and Pharmaceutical Bulletin, 1986
Some cinnamoyl-β-phenethylamine derivatives, gingerols, diarylheptanoids and acyldopamines were tested for their inhibitory effects on the 5-lipoxygenase of RBL-1 cells. Compounds containing a catechol group together with a lipophilic group strongly inhibited 5-lipoxygenase.
S, Iwakami, M, Shibuya, C F, Tseng, F, Hanaoka, U, Sankawa   +4 more
openaire   +3 more sources

Resolution of Pulmonary Inflammation Induced by Carbon Nanotubes and Fullerenes in Mice: Role of Macrophage Polarization

Frontiers in Immunology, 2020
Pulmonary exposure to certain engineered nanomaterials (ENMs) causes chronic lesions like fibrosis and cancer in animal models as a result of unresolved inflammation. Resolution of inflammation involves the time-dependent biosynthesis of lipid mediators (
Chol Seung Lim, Dale W. Porter, Marlene S. Orandle, Brett J. Green, Mark A. Barnes, Tara L. Croston, Michael G. Wolfarth, Lori A. Battelli, Michael E. Andrew, Michael E. Andrew, Donald H. Beezhold, Paul D. Siegel, Qiang Ma   +12 more
doaj   +1 more source

The chronic myeloid leukemia stem cell: stemming the tide of persistence [PDF]

, 2017
Chronic myeloid leukaemia (CML) is caused by the acquisition of the tyrosine kinase BCR-ABL1 in a haemopoietic stem cell (HSC), transforming it into a leukaemic stem cell (LSC) that self-renews, proliferates and differentiates to give rise to a ...
Holyoake, Tessa L., Vetrie, David
core   +1 more source

Exacerbation of Nanoparticle-Induced Acute Pulmonary Inflammation in a Mouse Model of Metabolic Syndrome

Frontiers in Immunology, 2020
Nanotechnology has the capacity to revolutionize numerous fields and processes, however, exposure-induced health effects are of concern. The majority of nanoparticle (NP) safety evaluations have been performed utilizing healthy models and have ...
Saeed Alqahtani, Saeed Alqahtani, Lisa M. Kobos, Li Xia, Christina Ferreira, Jackeline Franco, Xuqin Du, Jonathan H. Shannahan   +7 more
doaj   +1 more source

miR-155 Is a Positive Regulator of FcεRI-Induced Cyclooxygenase-2 Expression and Cytokine Production in Mast Cells

Frontiers in Allergy, 2022
MicroRNA-155 (miR-155) has been implicated in IgE-dependent allergic disease including asthma and atopic dermatitis. A few roles for miR-155 have been described in mast cells and some specifically related to IgE receptor signaling, but it is not ...
Zahraa Mohammed, Cody McHale, Jason L. Kubinak, Stuart Dryer, Gregorio Gomez   +4 more
doaj   +1 more source

Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase. [PDF]

, 2009
Pharmacological suppression of leukotriene biosynthesis by inhibitors of 5-lipoxygenase (5-LO) is a strategy to intervene with inflammatory and allergic disorders.
BÜHRING U, KARG EM, LUDERER S, NORTHOFF H, PERGOLA C, ROSSI, ANTONIETTA, SAUTEBIN, LIDIA, TROSCHÜTZ R, WERZ O.   +8 more
core   +1 more source

Five-lipoxygenase-activating protein-mediated CYLD attenuation is a candidate driver in hepatic malignant lesion

Frontiers in Oncology, 2022
Hepatocellular carcinoma (HCC) is an inflammation-associated cancer. However, the lipid pro-inflammatory mediators have only been seldom investigated in HCC pathogenesis. Cylindromatosis (CYLD) attenuation is involved in hepatocarcinogenesis.
Kun-kai Su, Kun-kai Su, Xue-hua Zheng, Xue-hua Zheng, Christian Bréchot, Xiao-ping Zheng, Dan-hua Zhu, Dan-hua Zhu, Rong Huang, Yan-hong Zhang, Yan-hong Zhang, Jing-jing Tao, Jing-jing Tao, Yi-jia Lou, Lan-juan Li, Lan-juan Li   +15 more
doaj   +1 more source

Microsomal glutathione transferase 1 confers cisplatin resistance of non-small cell lung cancer via interaction with arachidonate lipoxygenase 5 to repress ferroptosis [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Cisplatin (DDP) resistance remains a primary cause of chemotherapy failure and recurrence of non-small cell lung cancer (NSCLC). Abnormal high microsomal glutathione transferase 1 (MGST1) expression has been found in DDP-resistant NSCLC ...
Jun Yuan, Rui Zhang, Li Liu, Yue-song Ban, Ce Qin   +4 more
doaj   +1 more source

Eicosanoids in skin inflammation. [PDF]

, 2012
NoEicosanoids play an integral part in homeostatic mechanisms related to skin health and structural integrity. They also mediate inflammatory events developed in response to environmental factors, such as exposure to ultraviolet radiation, and ...
Agarwal, Albanesi, Andersen, Andoh, Andoh, Anna Nicolaou, Baer, Baer, Baron, Bergers, Black, Boeglin, Boguniewicz, Boyce, Brash, Bray, Bryniarski, Burke, Burr, Calder, Calder, Carlson, Carsberg, Chapkin, Chen, Chene, Church, Colombe, Crespy, De Nucci, Dennis, Doepping, Du, Epp, Fincham, Fisher, Fogh, Fogh, Fogh, Ford-Hutchinson, Gledhill, Goetzl, Gonzalez, Grabbe, Grabbe, Grant, Gresham, Grundmann, Gueck, Hansen, Harris, Honda, Honda, Honma, Hruza, Ikai, Ikai, Ikai, Janssen-Timmen, Jisaka, Judson, Judson, Kanda, Keeney, Keeney, Kolgen, Konger, Kragballe, Kragballe, Krieg, Kudo, Kuhn, Ladd, Leong, Levy, Lowes, Lu, Lu, Martin, Masoodi, Massey, Matsushima, Mayer, Mayser, McCusker, McDaniel, Millard, Miller, Miller, Milne, Muller, Nakajima, Narayanan, Nichols, Nicolaou, Nicolaou, Oka, Oyoshi, Parekh, Pentland, Pietrzak, Pilkington, Proksch, Rhodes, Rhodes, Ricketts, Rijken, Ruzicka, Sato, Satoh, Schafer, Schweiger, Scott, Scott, Scott, Serhan, Serhan, Shimura, Singh, Sjursen, Spanbroek, Stark, Straus, Sugimoto, Tai, Takeda, Ueno, Watanabe, Weber, Xi, Yoo, Zheng, Zhou, Ziboh, Ziboh, Ziboh, Ziboh, Ziboh, Zulfakar, Zuo   +139 more
core   +1 more source

A synthetic dl-nordihydroguaiaretic acid (Nordy), inhibits angiogenesis, invasion and proliferation of glioma stem cells within a zebrafish xenotransplantation model. [PDF]

PLoS ONE, 2014
The zebrafish (Danio rerio) and their transparent embryos represent a promising model system in cancer research. Compared with other vertebrate model systems, we had previously shown that the zebrafish model provides many advantages over mouse or chicken
Xiaojun Yang, Wei Cui, Shicang Yu, Chuan Xu, Guilai Chen, Ai Gu, Tingting Li, Youhong Cui, Xia Zhang, Xiuwu Bian   +9 more
doaj   +1 more source