Results 21 to 30 of about 16,348 (221)

Induction of Arachidonate 5‐Lipoxygenase and Arachidonate 5‐Lipoxygenase Activating Protein in Macrophages by Multi‐Walled Carbon Nanotubes

The FASEB Journal, 2021
Mammalian lungs respond to inhaled particulates including nanoparticles by eliciting inflammation. The initiation and resolution of inflammation are tightly controlled by potent proinflammatory and pro‐resolving lipid mediators. Dysregulation of lipid mediator production and function contributes to failure of particle clearance and
Chol Seung Lim, Qiang Ma
openaire   +1 more source

Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia [PDF]

, 2014
© The Author 2014. Published by Oxford University Press This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution,
Al-Mahdawi, Al-Mahdawi, Block, Campuzano, Campuzano, Capdevila, Capdevila, Castaldo, Chantrel-Groussard, Chen, Cossee, Dewitt, Durr, Durr, Feng, Genki Hayashi, Gino Cortopassi, Harding, John W. Newman, Kang, Koeppen, Li, Liang, Lin, Lu, Mark Pook, Masi, Michael, Miranda, Node, O'Flaherty, Paupe, Piemonte, Piro, Praticò, Qin, Ristow, Rojo, Samuelsson, Sanchez-Mejia, Schulz, Shan, Shi, Shin, Small, Smith, Strokin, Tan, Teismann, Theresa L. Pedersen, Tian, Wardlaw, Wong, Wong, Xi, Yan, Yan Shen, Zhang   +57 more
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5‐lipoxygenase‐activating protein is an arachidonate binding protein [PDF]

FEBS Letters, 1993
5‐Lipoxygenase‐activating protein (FLAP) is an 18‐kDa integral membrane protein which is essential for cellular leukotriene (LT) synthesis, and is the target of LT biosynthesis inhibitors. However, the mechanism by which FLAP activates 5‐LO has not been determined.
Mancini, Joseph A., Abramovitz, Mark, Cox, Martha E., Wong, Elizabeth, Charleson, Stella, Perrier, Hélène, Wang, Zhaoyin, Prasit, Peptiboon, Vickers, Philip J.   +8 more
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Altered eicosanoid production and phospholipid remodeling during cell culture[S]

Journal of Lipid Research, 2018
The remodeling of PUFAs by the Lands cycle is responsible for the diversity of phospholipid molecular species found in cells. There have not been detailed studies of the alteration of phospholipid molecular species as a result of serum starvation or ...
Toshiaki Okuno, Miguel A. Gijón, Simona Zarini, Sarah A. Martin, Robert M. Barkley, Christopher A. Johnson, Mai Ohba, Takehiko Yokomizo, Robert C. Murphy   +8 more
doaj   +1 more source

Modulation of Cox-1, 5-, 12- and 15-Lox by popular herbal remedies used in southern Italy against psoriasis and other skin diseases. [PDF]

, 2014
Acanthus mollis (Acanthaceae), Achillea ligustica, Artemisia arborescens and Inula viscosa (Asteraceae) are used in Southern Italy against psoriasis and other skin diseases that occur with an imbalanced production of eicosanoids.
Amenta, Ammon, Bader, Brand-Williams, Bremner, Bruni, Bruno, Charlier, Dehmlow, DiSepio, Flora, Glaser, Henke, Iversen, Luper, Mosmann, Pannala, Safayhi, Safayhi, Serhan, Spector, Sun, Tornhamre, Tzakou, Voorhees, Wang, Yamamoto   +26 more
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Fatty acid binding proteins stabilize leukotriene A4

Journal of Lipid Research, 2004
Leukotriene A4 (LTA4) is a chemically reactive conjugated triene epoxide product derived from 5-lipoxygenase oxygenation of arachidonic acid. At physiological pH, this reactive compound has a half-life of less than 3 s at 37°C and ∼40 s at 4°C ...
Jennifer S. Dickinson Zimmer, Douglas F. Dyckes, David A. Bernlohr, Robert C. Murphy   +3 more
doaj   +1 more source

Cell type-dependent activation of 5-lipoxygenase by arachidonic acid [PDF]

Journal of Leukocyte Biology, 2003
Abstract 5-Lipoxygenase (5-LO) is the key enzyme in the biosynthesis of proinflammatory leukotrienes. We show that stimulation of polymorphonuclear leukocytes (PMNL), rat basophilic leukemia (RBL)-1, or transfected HeLa cells with arachidonic acid (AA) caused prominent 5-LO product formation that coincided with the activity of ...
Eva, Bürkert, Dagmar, Szellas, Olof, Rådmark, Dieter, Steinhilber, Oliver, Werz   +4 more
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Identification of transcription factor binding sites in promoter databases [PDF]

, 2011
Transcription factors (TFs) are the proteins which regulates the expression of their target genes either in a positive or negative manner. TFs realize this task by binding to a specific DNA sequence contained in promoter regions, via their DNA binding ...
Dağ, Uğur, Durası, İlknur Melis, Erdoğan, Burcu, Güngör, Burcu Bakır, Kurnaz, Işıl Aksan, Sezerman, Uğur   +5 more
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Convergent Oxygenation of Arachidonic Acid by 5-Lipoxygenase and Cyclooxygenase-2 [PDF]

Journal of the American Chemical Society, 2005
5-Lipoxygenase and cyclooxygenase-2 (COX-2) initiate the biosynthesis of distinct families of mediators from arachidonic acid (leukotrienes and prostaglandins, respectively) and are each the target of anti-inflammatory medications. Here we show that the product of 5-lipoxygenase, 5S-hydroxyeicosatetraenoic acid, is selectively and efficiently triply ...
Claus, Schneider, William E, Boeglin, Huiyong, Yin, Donald F, Stec, Markus, Voehler   +4 more
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The role of vitamin C in the gene expression of oxidative stress markers in fibroblasts from burn patients [PDF]

Acta Cirúrgica Brasileira, 2018
Purpose: To assess the action of vitamin C on the expression of 84 oxidative stress related-genes in cultured skin fibroblasts from burn patients. Methods: Skin samples were obtained from ten burn patients.
Jessica Bonucci, Alfredo Gragnani, Marcelo Moraes Trincado, Victor Vincentin, Silvana Aparecida Alves Correa, Lydia Masako Ferreira   +5 more
doaj   +1 more source