Involvement of leukotriene pathway in the pathogenesis of ischemia-reperfusion injury and septic and non-septic shock. [PDF]
, 2009 The 5-lipoxygenase (5-LO) pathway is responsible for the production of leukotrienes (LTs), inflammatory lipid mediators which play a role in innate immunity. More recently, a pivotal role of LTs in ischemia-reperfusion and shock injury has been suggested.
CUZZOCREA S +2 more
core +1 more source
Mediators of Inflammation, 1993 The cytokines interleukin-8 (IL-8) and granulocyte-macrophage colony-stimulating factor (GM-CSF) enhanced the extracellular release of arachidonate metabolites from ionophore-stimulated neutrophils by 145 ± 10% (mean ± S.E.M., n = 13) and 182 ± 11% (n ...
P. J. Roberts, A. R. Pizzey, D. C. Linch
doaj +1 more source
Influence of leukotriene gene polymorphisms on chronic rhinosinusitis
BMC Medical Genetics, 2008 Background Chronic rhinosinusitis (CRS) is increasingly viewed as an inflammatory condition of the sinonasal mucosa interacting with bacteria and/or fungi. However, factors conferring susceptibility to disease remain unknown.
Duval Melanie +8 more
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Production of inflammatory mediators by human macrophages obtained from ascites [PDF]
, 1994 Ascites is a readily available source of human macrophages (Mø), which can be used to study Mø functions in vitro. We characterized the mediators of inflammation produced by human peritoneal Mø (hp-Mø) obtained from patients with portal hypertension and ...
Bonta, I.L. +5 more
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n-3系脂肪散を強化した食事療法が有効と考えられた肺気腫の一例 [PDF]
, 1998 An effective treatment for the advanced stages of chronic obstructive pulmonary disease (COPD) has not been established yet. We report our recent experience of one patient with pulmonary emphysema treated by dietary supplementation of n-3 fatty acid for ...
Ashida, Kozo +7 more
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Dormant 5-lipoxygenase in inflammatory macrophages is triggered by exogenous arachidonic acid [PDF]
Scientific Reports, 2017 AbstractThe differentiation of resident tissue macrophages from embryonic precursors and that of inflammatory macrophages from bone marrow cells leads to macrophage heterogeneity. Further plasticity is displayed through their ability to be polarized as subtypes M1 and M2 in a cell culture microenvironment. However, the detailed regulation of eicosanoid
Carlos A. Sorgi +9 more
openaire +2 more sources
Arachidonic acid and calcium metabolism in rnelittin stimulated neutrophils
Mediators of Inflammation, 1992 Melittin, the predominant fraction of bee venom proteins, was studied in an experimental model of human neutrophil granulocytes to reveal its influence on eicosanoid release, metabolism and receptor function in relation to intracellular calcium ...
Ole H. Nielsen +2 more
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Expression of mRNA for phospholipase A(2), cyclooxygenases, and lipoxygenases in cultured human umbilical vascular endothelial and smooth muscle cells and in biopsies from umbilical arteries and veins [PDF]
, 1998 Arachidonic acid (AA) is released by phospholipase A(2) (PLA(2)) and then converted into vasoactive and inflammatory eicosanoids by cyclooxygenases (COX) and lipoxygenases (LOX).
Carlsson, Maria +5 more
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Circulating Pro- and Anti-Inflammatory Metabolites and Its Potential Role in Rheumatoid Arthritis Pathogenesis. [PDF]
, 2020 Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects synovial joints, leading to inflammation, joint destruction, loss of function, and disability.
Coras, Roxana +2 more
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Decreased ovarian reserve, dysregulation of mitochondrial biogenesis, and increased lipid peroxidation in female mouse offspring exposed to an obesogenic maternal diet. [PDF]
, 2015 Maternal diet during pregnancy influences the later life reproductive potential of female offspring. We investigate the molecular mechanisms underlying the depletion of ovarian follicular reserve in young adult females following exposure to obesogenic ...
Aiken, Catherine E +4 more
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