Results 91 to 100 of about 4,073 (218)
Protein lipoylation in mitochondria requires Fe–S cluster assembly factors NFU4 and NFU5 [PDF]
, 2021 Jonathan Przybyla‐Toscano +7 more
openalex +1 more source
Targeted Intracellular Copper Reservoir Enhances Liver Cancer Immunotherapy
Small, Volume 21, Issue 36, September 11, 2025.Sono‐activatable TPEN‐encapsulated cancer‐targeted nanoparticles (STCNs) with sonodynamic therapy (SDT)‐amplified immunotherapeutic properties for liver cancer treatment via endogenous cuproptosis are developed. STCNs can effectively treat liver cancer through endogenous cuproptosis by TPEN and ROS generated by SDT, resulting in increased immune ...
Tianao Xie +15 more
wiley +1 more source
Astrocyte Lipid Droplet Dynamics Orchestrate Neurological Disorders and Therapeutic Horizons
Small Science, Volume 5, Issue 9, September 2025.This review examines astrocyte lipid droplet (LD) metabolism in neurological disorders, including Alzheimer's disease, stroke, epilepsy, and glioma. It analyzes regulatory mechanisms governing LD formation, transport, and degradation in astrocytes, highlighting their potential as biomarkers and therapeutic targets through integrative multiomics ...
Jiani Zhong +4 more
wiley +1 more source
Lipoamidase (lipoyl-X hydrolase) from pig brain [PDF]
Biochemical Journal, 1990 Although the optimum substrate for lipoamidase (lipoyl-X hydrolase) has not yet been determined, it is known that lipoamidase activity, as determined by hydrolysis of the synthetic substrate lipoyl 4-aminobenzoate (LPAB), is widely distributed in pig brain tissues, i.e. in the cerebrum, cerebellum and medulla. Over 95% of the enzyme activity is present
J Oizumi, K Hayakawa
openaire +3 more sources
Lipoate Metabolism in Staphylococcus Aureus Pathogenesis [PDF]
, 2016 Lipoate is an essential cofactor of several proteins involved in cellular energy homeostasis and catabolism. Lipoate metabolism has been linked to pathogenesis in some microbial species, but its role in Staphylococcus aureus infections had not been ...
Zorzoli, Maria Azul
core +1 more source
Advanced Science, Volume 12, Issue 29, August 7, 2025.This study prepares copper tungstate (CuWO4, CWO) nanoparticles for synergistic sono‐enhanced cuproptosis‐based cancer therapy. With an ultrasmall bandgap (1.71 eV), CWO facilitates efficient charge carrier separation under ultrasound, enhancing the generation of reactive oxygen species and the controlled release of Cu2+ ions cascade amplify oxidative ...
Lichao Zhu +9 more
wiley +1 more source
Mitochondrial acyl carrier protein (ACP) at the interface of metabolic state sensing and mitochondrial function [PDF]
, 2019 Acyl carrier protein (ACP) is a principal partner in the cytosolic and mitochondrial fatty acid synthesis (FAS) pathways. The active form holo-ACP serves as FAS platform, using its 4′-phosphopantetheine group to present covalently attached FAS ...
Autio, Kaija J. +4 more
core +1 more source
Advanced Science, Volume 12, Issue 29, August 7, 2025.This study proposes a novel HCC therapy using CA‐4S2@ES‐Cu nanomedicines to amplify cuproptosis, enhancing chemotherapy and immunotherapy. CA‐4 and ES‐Cu synergistically inhibit tumor growth, induce immune responses, and reverse the immunosuppressive microenvironment, offering an effective multidimensional therapeutic strategy for HCC treatment ...
Yingjie Zeng +16 more
wiley +1 more source
Library of Apicomplexan Metabolic Pathways: a manually curated database for metabolic pathways of apicomplexan parasites. [PDF]
, 2012 The Library of Apicomplexan Metabolic Pathways (LAMP, http://www.llamp.net) is a web database that provides near complete mapping from genes to the central metabolic functions for some of the prominent intracellular parasites of the phylum Apicomplexa ...
Gonzalez-Galarza, FF +4 more
core +1 more source
Advanced Science, Volume 12, Issue 32, August 28, 2025.We designed a copper‐based nanotube (NT) with copper ionophores to induce enhanced cuproptosis. In combination with starvation therapy, the NT significantly inhibited energy metabolism in HCC cells. Our results show that the depletion of GSH by Cu2+ intensified oxidative stress and cuproptosis, resulting in ROS generation and DLAT aggregation ...
Xuan Han +8 more
wiley +1 more source