Glycine decarboxylase maintains mitochondrial protein lipoylation to support tumor growth
, 2022 Dzmitry Mukha +10 more
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The Fe-S cluster assembly factors NFU4 and NFU5 are primarily required for protein lipoylation in mitochondria [PDF]
, 2021 Jonathan Przybyla‐Toscano +7 more
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Distinctive phosphoinositide- and Ca²⁺-binding properties of normal and cognitive performance–linked variant forms of KIBRA C2 domain [PDF]
, 2018 Kidney- and brain-expressed protein (KIBRA), a multifunctional scaffold protein with around 20 known binding partners, is involved in memory and cognition, organ size control via the Hippo pathway, cell polarity, and membrane trafficking.
Bagby, S +8 more
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Post-translational modification in the archaea: structural characterization of multi-enzyme complex lipoylation [PDF]
, 2012 Mareike G. Posner +6 more
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CellsCuproptosis is a novel cell death dependent on mitochondrial respiration and regulated by copper. While the study of it is mainly focused on tumor therapy, in the present study, two key cuproptosis-related genes, ferredoxin (FDX1) and dihydrolipoamide S ...
Yuxin Zhang +4 more
doaj +1 more source
Mutations in the lipoyltransferaseLIPT1gene cause a fatal disease associated with a specific lipoylation defect of the 2-ketoacid dehydrogenase complexes [PDF]
, 2013 Frederic Tort +14 more
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Blood Advances, 2018 : Given the essential roles of iron-sulfur (Fe-S) cofactors in mediating electron transfer in the mitochondrial respiratory chain and supporting heme biosynthesis, mitochondrial dysfunction is a common feature in a growing list of human Fe-S cluster ...
Wing-Hang Tong +7 more
doaj +1 more source
The 3-hydroxyacyl-ACP dehydratase component of the plant mitochondrial fatty acid synthase system [PDF]
, 2017 We report the characterization of the Arabidopsis 3-hydroxyacyl-acyl carrier protein (ACP) dehydratase (mtHD) component of the mitochondrial fatty acid synthase (mtFAS) system, encoded by AT5G60335. The mitochondrial localization and catalytic capability
Guan, Xin +11 more
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Mitochondria as a primary determinant of angiogenic modality in pulmonary arterial hypertension. [PDF]
Impaired pulmonary angiogenesis plays a pivotal role in the progression of pulmonary arterial hypertension (PAH) and patient mortality, yet the molecular mechanisms driving this process remain enigmatic.
Baggett, Brenda +11 more
core +1 more source