Results 121 to 130 of about 4,073 (218)

Ferredoxin 1 is essential for embryonic development and lipid homeostasis

eLife
Mammalian ferredoxin 1 and 2 (FDX1/2) belong to an evolutionary conserved family of iron-sulfur cluster containing proteins and act as electron shutters between ferredoxin reductase (FDXR) and numerous proteins involved in critical biological pathways ...
Shakur Mohibi, Yanhong Zhang, Vivian Perng, Mingyi Chen, Jin Zhang, Xinbin Chen   +5 more
doaj   +1 more source

Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis, and beyond. [PDF]

Protein Cell
Cell death resistance represents a hallmark of cancer. Recent studies have identified metabolic cell death as unique forms of regulated cell death resulting from an imbalance in the cellular metabolism.
Mao C, Wang M, Zhuang L, Gan B.
europepmc   +3 more sources

Studying the Lipoyl Synthase mediated conversion of Octanoyl substrates to Lipoyl products

, 2013
a-Lipoic acid is a cofactor used during oxidative metabolism reactions by several enzymes, including branched chain keto acid dehydrogenases, the glycine cleavage system, pyruvate dehydrogenase and a-ketoglutarate dehydrogenase. The lipoic acid is attached to the e-amino group of a specific lysine residue via an amide bond and acts as a carrier of acyl
openaire   +1 more source

Inducers of Autophagy and Cell Death: Focus on Copper Metabolism

Ecotoxicology and Environmental Safety
Copper is an essential trace element in biological systems, playing a key role in various physiological functions, including redox reactions and energy metabolism.
Weikang Ling, Shuo Li, Yang Zhu, Xin Wang, Dongmei Jiang, Bo Kang   +5 more
doaj   +1 more source

Analysis of genetic mutations using a recombinant model of the mammalian pyruvate dehydrogenase complex [PDF]

, 2008
The human mitochondrial pyruvate dehydrogenase complex (PDC) is a vital metabolic assembly that controls the key committed step in aerobic carbohydrate utilisation and energy production and as such is responsible for overall glucose homeostasis in man ...
Singh, Geetanjali
core   +1 more source

cDNA sequence, in vitro synthesis, and intramitochondrial lipoylation of H-protein of the glycine cleavage system.

, 1990
Kazuko Fujiwara, Kazuko Okamura‐Ikeda, Y. Motokawa   +2 more
openalex   +1 more source

Coupling of the de Novo Fatty Acid Biosynthesis and Lipoylation Pathways in Mammalian Mitochondria [PDF]

, 2007
Andrzej Witkowski, Anil K. Joshi, Sean C. Smith   +2 more
openalex   +1 more source

Structural basis for catalysis by human lipoyl synthase

Nature Communications
Abstract Lipoic acid is an essential cofactor in five mitochondrial multiprotein complexes. In each complex, it is tethered in an amide linkage to the side chain of a conserved lysyl residue on a lipoyl carrier protein or lipoyl domain to afford the lipoyl cofactor.
Olga A. Esakova, Douglas M. Warui, Syam Sundar Neti, John N. Alumasa, Squire J. Booker   +4 more
openaire   +1 more source

Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions [PDF]

, 2016
Stephen P. Burr, Ana S.H. Costa, Guinevere L. Grice, Richard T. Timms, Ian Lobb, Peter Freisinger, Roger B. Dodd, Gordon Dougan, Paul J. Lehner, Christian Frezza, James A. Nathan   +10 more
openalex   +1 more source

Cuproptosis, the novel type of oxidation-induced cell death in thoracic cancers: can it enhance the success of immunotherapy?

Cell Communication and Signaling
Copper is an important metal micronutrient, required for the balanced growth and normal physiological functions of human organism. Copper-related toxicity and dysbalanced metabolism were associated with the disruption of intracellular respiration and the
Ruiwen Zhao, Olga Sukocheva, Edmund Tse, Margarita Neganova, Yulia Aleksandrova, Yufei Zheng, Hao Gu, Deyao Zhao, SabbaRao V. Madhunapantula, Xiaorong Zhu, Junqi Liu, Ruitai Fan   +11 more
doaj   +1 more source