Results 121 to 130 of about 5,116,830 (334)

Spatially Controlled Embedded Bioprinting of Prevascularized Spheroids‐Containing Biopatch Enables Functional Skin Regeneration

Advanced Healthcare Materials, EarlyView.
A spatially controlled embedded bioprinting strategy enables precise engineering of prevascularized multicellular spheroids within skin‐derived dECM bioinks. Optimized spheroid size, composition, and spacing promote vascular maturation, paracrine signaling, and tissue integration, resulting in enhanced angiogenesis, blood perfusion, and functional skin
Minjun Ahn, Gyu Tae Park, Dongjun Lee, Sik Yoon, Sae‐Ock Oh, Jae Ho Kim, Byoung Soo Kim   +6 more
wiley   +1 more source

Recommendations for the Equitable and Widespread Implementation of Liquid Biopsy for Cancer Care

JCO Precision Oncology
Liquid biopsies—tests that detect circulating tumor cellular components in the bloodstream—have the potential to transform cancer by reducing health inequities in screening, diagnostics, and monitoring.
Phillip G. Febbo, Mina Allo, Emma Alme, Gebra Cuyun Carter, R. Dumanois, A. Essig, Estevan P. Kiernan, Caitlin B Kubler, N. Martin, M. Popescu, Lauren C. Leiman   +10 more
semanticscholar   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Lab-on-a-Disc for Liquid Biopsy

, 2018
The lab-on-a-disc systems to isolate and detect liquid biopsy markers such as circulating tumor cells (CTCs) and cell-free DNA(cfDNA) or Extracellular vesicles (EVs) are developed and tested with clinical samples such as whole blood or urine from cancer ...
Cho, Yoon-Kyoung
core  

Unlocking the promise of liquid biopsies in precision oncology

Liquid biopsies have emerged as a promising and minimally invasive alternative to traditional tissue biopsies for detecting and monitoring cancer. Liquid biopsies offer a comprehensive analysis of cancer genetics and tumor burden by examining circulating
Pando-Caciano, Alejandra, Debattista, Jessica, Trivedi, Rakesh, Alejandra Pando-Caciano, Lovisa Falkman, Jessica Debattista, Pauwels, Jarne, Joanna Nowakowska, Szilárd-Krisztián Belényesi, Periyasamy Radhakrishnan, Rakesh Trivedi, Beatrice Cavina, Nowakowska, Joanna, Mariano A. Molina, Falkman, Lovisa, Cavina, Beatrice, Jarne Pauwels, Radhakrishnan, Periyasamy, Molina, Mariano A., Falkman, Lovisa,, Radhakrishnan, Periyasamy,, Molina, Mariano A.,, Cavina, Beatrice,, Pauwels, Jarne,, Belényesi, Szilárd-Krisztián, Trivedi, Rakesh,, Nowakowska, Joanna,, Belenyesi, Szilard-Krisztian,, Debattista, Jessica,, Pando-Caciano, Alejandra,   +29 more
core   +1 more source

Self‐Healing Hydrogel‐Enabled Modular Assembly of Bilayered Skin Construct for Hair Follicle Regeneration

Advanced Healthcare Materials, EarlyView.
Self‐healing assembly of two cell‐laden hydrogel layers creates a biomimetic skin construct that restores both dermal and epidermal functions, resulting in accelerated wound healing and enhanced hair follicle regeneration in a full‐thickness skin wound model. ABSTRACT Alopecia remains a pervasive clinical challenge, largely owing to the limited ability
JaeWook Park, Su Yong Kim, MinSu Jeong, Beom Joon Kim, Shin Hyuk Kang, Won‐Gun Koh   +5 more
wiley   +1 more source

Beyond blood: Advancing the frontiers of liquid biopsy in oncology and personalized medicine

Cancer Science
Liquid biopsy is emerging as a pivotal tool in precision oncology, offering a noninvasive and comprehensive approach to cancer diagnostics and management.
Y. Bao, Dejing Zhang, Hui-Hui Guo, Wen-Xue Ma   +3 more
semanticscholar   +1 more source

Microgels Enable iPSCs to Assemble, Expand, and Differentiate Into Organoids—From Sizable to High‐Throughput

Advanced Materials, EarlyView.
A chemically defined PEG‐based microgel platform enables scalable, reproducible production of three‐dimensional microgel‐iPSC constructs in multiple sizes. The system is compatible with high‐throughput automation and supports human iPSC expansion and differentiation within a single construct, including directed differentiation into cardiac organoids ...
Laura Klasen, Matthias Mork, Ramin Nasehi, Vasudha Turuvekere Krishnamurthy, Kira Zeevaert, Aaron Babendreyer, Jacopo Di Russo, Wolfgang Wagner, Laura De Laporte   +8 more
wiley   +1 more source

Afatinib for Advanced Non-small Cell Lung Cancer in a Case With an Uncommon Epidermal Growth Factor Receptor Mutation (G719A) Identified in the Cerebrospinal Fluid

Frontiers in Oncology, 2019
Few previous studies of patients with non-small cell lung cancer (NSCLC) and leptomeningeal metastases have used liquid biopsy of cerebrospinal fluid (CSF) to identify epidermal growth factor receptor (EGFR) mutations and guide therapy.
Chunhua Ma, Chuoji Huang, Chuoji Huang, Dongjiang Tang, Dongjiang Tang, Xin Ye, Xin Ye, Zhi Li, Renzhong Liu, Ning Mu, Jing Li, Rong Jiang, Juncheng Zhang, Juncheng Zhang   +13 more
doaj   +1 more source

The Role of Circulating Tumor Cells as a Liquid Biopsy for Cancer: Advances, Biology, Technical Challenges, and Clinical Relevance

Cancers
Simple Summary This review article explores the forefront of research and technology in the detection and isolation of circulating tumor cells (CTCs) for liquid biopsy applications. Traditional biopsies, which necessitate tissue samples, are invasive and
Tyler A. Allen
semanticscholar   +1 more source